Drug Detail

Drug Name Bortezomib
Trade Name Velcade
Synonyms
Drug Descriptions

Velcade (bortezomib) inhibits cellular proteasome activity, thereby altering multiple signaling pathways and induces cytotoxicity and apoptosis. Velcade (bortezomib) also inactivates the NF-kB pathway in various cancers (PMID: 20530581). Velcade (bortezomib) is FDA approved for the treatment of relapsed and refractory mantle cell lymphoma and refractory multiple myeloma (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-075 + Bortezomib ABBV-075 Bortezomib 2 0
Aldoxorubicin + Bendamustine + Bortezomib Aldoxorubicin Bendamustine Bortezomib 0 0
Alisertib + Bortezomib + Rituximab Alisertib Bortezomib Rituximab 0 1
BC2059 + Bortezomib BC2059 Bortezomib 1 0
Bendamustine + Bortezomib + Ofatumumab Bendamustine Bortezomib Ofatumumab 0 1
Bendamustine + Bortezomib + Pegylated liposomal-doxorubicin Bendamustine Bortezomib Pegylated liposomal-doxorubicin 0 1
Bendamustine + Bortezomib + Rituximab Bendamustine Bortezomib Rituximab 1 0
Bevacizumab + Bortezomib + Temozolomide Bevacizumab Bortezomib Temozolomide 0 1
Bortezomib Bortezomib 2 38
Bortezomib + BX-912 BX-912 Bortezomib 0 0
Bortezomib + Cannabidiol Bortezomib Cannabidiol 0 1
Bortezomib + Carfilzomib + Clarithromycin Bortezomib Carfilzomib Clarithromycin 0 1
Bortezomib + Cladribine + Rituximab Bortezomib Cladribine Rituximab 0 1
Bortezomib + Clofarabine Bortezomib Clofarabine 0 1
Bortezomib + Cyclophosphamide Bortezomib Cyclophosphamide 0 2
Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone Bortezomib Cyclophosphamide Daratumumab Dexamethasone 0 1
Bortezomib + Cyclophosphamide + Filgrastim Bortezomib Cyclophosphamide Filgrastim 0 1
Bortezomib + Cyclophosphamide + Lenalidomide Bortezomib Cyclophosphamide Lenalidomide 0 1
Bortezomib + Cyclosporine + Mycophenolate mofetil Bortezomib Cyclosporine Mycophenolate mofetil 0 1
Bortezomib + Cytarabine + Etoposide + Midostaurin + Mitoxantrone Bortezomib Cytarabine Etoposide Midostaurin Mitoxantrone 1 0
Bortezomib + Daratumumab + Dexamethasone Bortezomib Daratumumab Dexamethasone 1 4
Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Bortezomib Daratumumab Dexamethasone Lenalidomide 0 2
Bortezomib + Daratumumab + Dexamethasone + Melphalan + Prednisone Bortezomib Daratumumab Dexamethasone Melphalan Prednisone 0 1
Bortezomib + Daratumumab + Dexamethasone + Venetoclax Bortezomib Daratumumab Dexamethasone Venetoclax 0 2
Bortezomib + Dasatinib + Dexamethasone + Doxorubicin + Palbociclib Bortezomib Dasatinib Dexamethasone Doxorubicin Palbociclib 0 1
Bortezomib + Decitabine + Sorafenib Bortezomib Decitabine Sorafenib 0 1
Bortezomib + Dexamethasone Bortezomib Dexamethasone 0 8
Bortezomib + Dexamethasone + Dinaciclib Bortezomib Dexamethasone Dinaciclib 0 1
Bortezomib + Dexamethasone + Elotuzumab + Lenalidomide Bortezomib Dexamethasone Elotuzumab Lenalidomide 0 1
Bortezomib + Dexamethasone + Elotuzumab + Panobinostat Bortezomib Dexamethasone Elotuzumab Panobinostat 0 1
Bortezomib + Dexamethasone + GSK2857916 Bortezomib Dexamethasone GSK2857916 0 1
Bortezomib + Dexamethasone + Iberdomide Bortezomib Dexamethasone Iberdomide 0 1
Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Bortezomib Dexamethasone Isatuximab Lenalidomide 0 1
Bortezomib + Dexamethasone + Lenalidomide Bortezomib Dexamethasone Lenalidomide 1 10
Bortezomib + Dexamethasone + Lenalidomide + Panobinostat Bortezomib Dexamethasone Lenalidomide Panobinostat 0 2
Bortezomib + Dexamethasone + LGH447 Bortezomib Dexamethasone LGH447 0 0
Bortezomib + Dexamethasone + Linsitinib Bortezomib Dexamethasone Linsitinib 0 1
Bortezomib + Dexamethasone + Melflufen Bortezomib Dexamethasone Melflufen 0 1
Bortezomib + Dexamethasone + Melphalan + Thalidomide Bortezomib Dexamethasone Melphalan Thalidomide 0 2
Bortezomib + Dexamethasone + Panobinostat Bortezomib Dexamethasone Panobinostat 1 4
Bortezomib + Dexamethasone + Pomalidomide Bortezomib Dexamethasone Pomalidomide 0 1
Bortezomib + Dexamethasone + Radium Ra 223 dichloride Bortezomib Dexamethasone Radium Ra 223 dichloride 0 1
Bortezomib + Dexamethasone + Reolysin Bortezomib Dexamethasone Reolysin 0 1
Bortezomib + Dexamethasone + Ricolinostat Bortezomib Dexamethasone Ricolinostat 1 0
Bortezomib + Dexamethasone + Selinexor Bortezomib Dexamethasone Selinexor 0 1
Bortezomib + Dexamethasone + Ulocuplumab Bortezomib Dexamethasone Ulocuplumab 0 1
Bortezomib + Dexamethasone + Venetoclax Bortezomib Dexamethasone Venetoclax 0 2
Bortezomib + DT204 Bortezomib DT204 1 0
Bortezomib + Duvelisib Bortezomib Duvelisib 0 1
Bortezomib + Everolimus Bortezomib Everolimus 0 1
Bortezomib + Fasudil Bortezomib Fasudil 1 0
Bortezomib + Filgrastim Bortezomib Filgrastim 0 2
Bortezomib + Fludarabine + Melphalan Bortezomib Fludarabine Melphalan 0 1
Bortezomib + GO-203-2C Bortezomib GO-203-2C 0 1
Bortezomib + Ibrutinib Bortezomib Ibrutinib 0 1
Bortezomib + Lapatinib Bortezomib Lapatinib 0 1
Bortezomib + Lenalidomide Bortezomib Lenalidomide 0 1
Bortezomib + Lenalidomide + PAT-SM6 Bortezomib Lenalidomide PAT-SM6 0 0
Bortezomib + Metformin + Nelfinavir Bortezomib Metformin Nelfinavir 0 1
Bortezomib + Oxaliplatin Bortezomib Oxaliplatin 0 1
Bortezomib + Palbociclib Bortezomib Palbociclib 0 1
Bortezomib + Panobinostat Bortezomib Panobinostat 1 0
Bortezomib + Pegylated liposomal-doxorubicin Bortezomib Pegylated liposomal-doxorubicin 0 1
Bortezomib + Plerixafor Bortezomib Plerixafor 0 1
Bortezomib + Pravastatin Bortezomib Pravastatin 0 1
Bortezomib + Ribociclib Bortezomib Ribociclib 2 0
Bortezomib + Rituximab Bortezomib Rituximab 0 2
Bortezomib + Ruxolitinib Bortezomib Ruxolitinib 0 1
Bortezomib + SJB3-019A Bortezomib SJB3-019A 1 0
Bortezomib + Sonidegib Bortezomib Sonidegib 0 1
Bortezomib + Sorafenib + Vorinostat Bortezomib Sorafenib Vorinostat 0 1
Bortezomib + Tapalumab Bortezomib Tapalumab 1 0
Bortezomib + Temozolomide Bortezomib Temozolomide 0 1
Bortezomib + Temsirolimus + Topotecan Bortezomib Temsirolimus Topotecan 0 0
Bortezomib + Tinostamustine Bortezomib Tinostamustine 7 0
Bortezomib + Torkinib Bortezomib Torkinib 1 0
Bortezomib + Vorinostat Bortezomib Vorinostat 1 0