Drug Detail


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Drug Name LGH447
Trade Name
Synonyms LGB321|PIM447|LGH-447|PIM-447
Drug Descriptions

LGH447 is a pan-PIM protein kinase inhibitor, which leads to cell cycle arrest and growth inhibition in PIM-expressing tumor cells (PMID: 24474669, PMID: 30370255).

DrugClasses PIM Inhibitor (Pan) 9
CAS Registry Number 1210608-43-7
NCIT ID C106259


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + LGH447 Alpelisib LGH447 0 1
Bortezomib + Dexamethasone + LGH447 Bortezomib Dexamethasone LGH447 0 0
Cytarabine + LGH447 Cytarabine LGH447 0 0
Dexamethasone + Lenalidomide + LGH447 Dexamethasone LGH447 Lenalidomide 0 0
Dexamethasone + LGH447 Dexamethasone LGH447 0 0
Dexamethasone + LGH447 + Pomalidomide Dexamethasone LGH447 Pomalidomide 0 0
LGH447 LGH447 0 3
LGH447 + Ribociclib + Ruxolitinib LGH447 Ribociclib Ruxolitinib 2 0

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