Drug Detail

Drug Name Ruxolitinib
Trade Name Jakafi
Synonyms INCB 18424|INCB018424|INCB18424
Drug Descriptions

Jakafi (ruxolitinib) is an inhibitor of protein tyrosine kinases JAK1 and JAK2, thus resulting in reduced inflammation and reduced proliferation (PMID: 22474318). Jakafi (ruxolitinib) is FDA approved to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis (FDA.gov)

DrugClasses JAK1 Inhibitor - ATP competitive 4 JAK2 Inhibitor - ATP competitive 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD1208 + Ruxolitinib AZD1208 Ruxolitinib 2 0
BEZ235 + Ruxolitinib BEZ235 Ruxolitinib 5 0
Bortezomib + Ruxolitinib Bortezomib Ruxolitinib 0 1
Bosutinib + Ruxolitinib Bosutinib Ruxolitinib 0 1
Capecitabine + Regorafenib + Ruxolitinib Capecitabine Regorafenib Ruxolitinib 0 1
Capecitabine + Ruxolitinib Capecitabine Ruxolitinib 1 2
Carfilzomib + Dexamethasone + Ruxolitinib Carfilzomib Dexamethasone Ruxolitinib 0 1
Cisplatin + Pemetrexed + Ruxolitinib Cisplatin Pemetrexed Ruxolitinib 0 1
CPX-351 + Ruxolitinib CPX-351 Ruxolitinib 0 1
Cyclophosphamide + Doxorubicin + Paclitaxel + Ruxolitinib Cyclophosphamide Doxorubicin Paclitaxel Ruxolitinib 0 1
Dasatinib + Dexamethasone + Ruxolitinib Dasatinib Dexamethasone Ruxolitinib 0 1
Dasatinib + Ruxolitinib Dasatinib Ruxolitinib 0 2
Decitabine + Ruxolitinib Decitabine Ruxolitinib 0 2
Erlotinib + Ruxolitinib Erlotinib Ruxolitinib 0 1
Exemestane + Ruxolitinib Exemestane Ruxolitinib 0 1
Ibrutinib + Ruxolitinib Ibrutinib Ruxolitinib 2 1
Imatinib + Ruxolitinib Imatinib Ruxolitinib 0 1
Itacitinib + Ruxolitinib Itacitinib Ruxolitinib 0 1
Lenalidomide + Methylprednisolone + Ruxolitinib Lenalidomide Methylprednisolone Ruxolitinib 0 1
Nilotinib + Ruxolitinib Nilotinib Ruxolitinib 0 5
Nivolumab + Ruxolitinib Nivolumab Ruxolitinib 0 1
Paclitaxel + Ruxolitinib Paclitaxel Ruxolitinib 0 1
Parsaclisib + Ruxolitinib Parsaclisib Ruxolitinib 0 1
Pembrolizumab + Ruxolitinib Pembrolizumab Ruxolitinib 0 1
Pictilisib + Ruxolitinib Pictilisib Ruxolitinib 5 0
PU-H71 + Ruxolitinib PU-H71 Ruxolitinib 0 1
RP6530 + Ruxolitinib RP6530 Ruxolitinib 1 0
Ruxolitinib Ruxolitinib 24 35
Ruxolitinib + Selumetinib Ruxolitinib Selumetinib 0 0
Ruxolitinib + SGI-1776 Ruxolitinib SGI-1776 1 0
Ruxolitinib + Sirolimus + Tacrolimus Ruxolitinib Sirolimus Tacrolimus 0 1
Ruxolitinib + Temozolomide Ruxolitinib Temozolomide 0 1
Ruxolitinib + Temsirolimus Ruxolitinib Temsirolimus 1 0
Ruxolitinib + TGX-221 Ruxolitinib TGX-221 5 0
Ruxolitinib + Trametinib Ruxolitinib Trametinib 0 0
Ruxolitinib + Trastuzumab Ruxolitinib Trastuzumab 0 1
Ruxolitinib + Umbralisib Ruxolitinib Umbralisib 0 1
Ruxolitinib + Venetoclax Ruxolitinib Venetoclax 0 1
Ruxolitinib + ZSTK474 Ruxolitinib ZSTK474 5 0