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Drug Name Neratinib
Trade Name Nerlynx
Synonyms HKI-272|PB272
Drug Descriptions

Nerlynx (neratinib) inhibits the ERBB2 (HER2) receptor as well as EGFR, resulting in decreased proliferation of HER2 and EGFR expressing tumor cells (PMID: 15173008). Nerlynx (neratinib) is FDA approved for use in patients with early stage ERBB2 (HER2)-positive breast cancer following Herceptin (trastuzumab)-based therapy, and in combination with Xeloda (capecitabine) in patients with advanced/metastatic ERBB2 (HER2)-positive breast cancer who have received two or more anti-ERBB2 (HER2) regimens (FDA.gov).

DrugClasses HER2 Inhibitor 23

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Neratinib Ado-trastuzumab emtansine Neratinib 0 1
Capecitabine + Neratinib Capecitabine Neratinib 4 3
Carboplatin + Neratinib + Paclitaxel Carboplatin Neratinib Paclitaxel 0 1
Cetuximab + Neratinib Cetuximab Neratinib 0 2
Cyclophosphamide + Doxorubicin + Neratinib + Paclitaxel Cyclophosphamide Doxorubicin Neratinib Paclitaxel 0 2
Cyclophosphamide + Doxorubicin + Neratinib + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Neratinib Paclitaxel Trastuzumab 0 1
Divalproex sodium + Neratinib Divalproex sodium Neratinib 0 1
Elgemtumab + Neratinib Elgemtumab Neratinib 1 0
Everolimus + Fulvestrant + Neratinib Everolimus Fulvestrant Neratinib 0 0
Everolimus + Neratinib Everolimus Neratinib 3 1
Fulvestrant + Neratinib Fulvestrant Neratinib 0 2
Fulvestrant + Neratinib + Trastuzumab Fulvestrant Neratinib Trastuzumab 0 2
Gedatolisib + Neratinib Gedatolisib Neratinib 0 0
Loperamide + Neratinib Loperamide Neratinib 0 0
Neratinib Neratinib 161 8
Neratinib + Paclitaxel Neratinib Paclitaxel 1 1
Neratinib + Paclitaxel + Pertuzumab + Trastuzumab Neratinib Paclitaxel Pertuzumab Trastuzumab 0 2
Neratinib + Palbociclib Neratinib Palbociclib 0 1
Neratinib + Pertuzumab Neratinib Pertuzumab 1 0
Neratinib + Pictilisib Neratinib Pictilisib 1 0
Neratinib + Selumetinib Neratinib Selumetinib 1 0
Neratinib + Taselisib Neratinib Taselisib 3 0
Neratinib + Temozolomide Neratinib Temozolomide 0 1
Neratinib + Temsirolimus Neratinib Temsirolimus 2 1
Neratinib + Trametinib Neratinib Trametinib 0 1
Neratinib + Trastuzumab Neratinib Trastuzumab 3 4


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