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Drug Name Neratinib
Trade Name Nerlynx
Synonyms HKI-272|PB272
Drug Descriptions

Nerlynx (neratinib) inhibits the ERBB2 (HER2) receptor as well as EGFR, resulting in decreased proliferation of HER2 and EGFR expressing tumor cells (PMID: 15173008). Nerlynx (neratinib) is FDA approved for use in patients with early stage ERBB2 (HER2)-positive breast cancer following Herceptin (trastuzumab)-based therapy, and in combination with Xeloda (capecitabine) in patients with advanced/metastatic ERBB2 (HER2)-positive breast cancer who have received two or more anti-ERBB2 (HER2) regimens (FDA.gov).

DrugClasses HER2 Inhibitor 41
CAS Registry Number 915942-22-2
NCIT ID C136891

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Neratinib Ado-trastuzumab emtansine Neratinib 0 1
Alisertib + Neratinib Alisertib Neratinib 0 0
Alpelisib + Neratinib Alpelisib Neratinib 0 0
Anastrozole + Neratinib Anastrozole Neratinib 0 1
Anastrozole + Neratinib + Trastuzumab Anastrozole Neratinib Trastuzumab 0 1
BIRB-796 + Neratinib BIRB-796 Neratinib 0 0
Buparlisib + Neratinib Buparlisib Neratinib 0 0
Capecitabine + Neratinib Capecitabine Neratinib 0 3
Capmatinib + Neratinib Capmatinib Neratinib 0 1
Carboplatin + Neratinib + Paclitaxel Carboplatin Neratinib Paclitaxel 0 1
Cetuximab + Neratinib Cetuximab Neratinib 0 2
Copanlisib + Neratinib Copanlisib Neratinib 2 0
Cyclophosphamide + Doxorubicin + Neratinib + Paclitaxel Cyclophosphamide Doxorubicin Neratinib Paclitaxel 0 2
Cyclophosphamide + Doxorubicin + Neratinib + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Neratinib Paclitaxel Trastuzumab 0 1
Divalproex sodium + Neratinib Divalproex sodium Neratinib 0 1
Elgemtumab + Neratinib Elgemtumab Neratinib 0 0
Eribulin + Neratinib Eribulin Neratinib 0 0
Everolimus + Fulvestrant + Neratinib Everolimus Fulvestrant Neratinib 0 0
Everolimus + Neratinib Everolimus Neratinib 0 1
Exemestane + Neratinib Exemestane Neratinib 0 1
Fluorouracil + Leucovorin + Neratinib + Oxaliplatin + Pembrolizumab + Trastuzumab Fluorouracil Leucovorin Neratinib Oxaliplatin Pembrolizumab Trastuzumab 0 1
Fulvestrant + Neratinib Fulvestrant Neratinib 0 6
Fulvestrant + Neratinib + Trastuzumab Fulvestrant Neratinib Trastuzumab 0 2
Gedatolisib + Neratinib Gedatolisib Neratinib 0 0
Letrozole + Neratinib Letrozole Neratinib 0 1
Letrozole + Neratinib + Trastuzumab Letrozole Neratinib Trastuzumab 0 1
Loperamide + Neratinib Loperamide Neratinib 0 0
MRTX-1133 + Neratinib MRTX-1133 Neratinib 0 0
Neratinib Neratinib 10 14
Neratinib + Niraparib Neratinib Niraparib 0 1
Neratinib + Paclitaxel Neratinib Paclitaxel 0 1
Neratinib + Paclitaxel + Pertuzumab + Trastuzumab Neratinib Paclitaxel Pertuzumab Trastuzumab 0 2
Neratinib + Palbociclib Neratinib Palbociclib 0 3
Neratinib + Pertuzumab Neratinib Pertuzumab 0 0
Neratinib + Pertuzumab + Trastuzumab Neratinib Pertuzumab Trastuzumab 0 0
Neratinib + Pictilisib Neratinib Pictilisib 0 0
Neratinib + Ribociclib Neratinib Ribociclib 0 0
Neratinib + Ruxolitinib Neratinib Ruxolitinib 0 1
Neratinib + Sapanisertib Neratinib Sapanisertib 0 0
Neratinib + Selumetinib Neratinib Selumetinib 0 0
Neratinib + Sotorasib Neratinib Sotorasib 0 0
Neratinib + Tamoxifen Neratinib Tamoxifen 0 1
Neratinib + Taselisib Neratinib Taselisib 0 0
Neratinib + Temozolomide Neratinib Temozolomide 0 1
Neratinib + Temsirolimus Neratinib Temsirolimus 0 1
Neratinib + Trametinib Neratinib Trametinib 0 1
Neratinib + Trastuzumab Neratinib Trastuzumab 0 6
Neratinib + Trastuzumab deruxtecan Neratinib Trastuzumab deruxtecan 0 1
Neratinib + Vinorelbine Neratinib Vinorelbine 0 0


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