Drug Detail


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Drug Name Elgemtumab
Trade Name
Synonyms LJM716|LJM-716
Drug Descriptions

Elgemtumab (LJM716) is a monoclonal antibody that targets ErbB3 (Her3) and prevents its transition into an active conformation, resulting in inhibition of ligand-dependent and ligand-independent downstream signaling and decreased tumor cell proliferation (PMID: 23928993, PMID: 27942917).

DrugClasses HER3 (ERBB3) Antibody 23
CAS Registry Number 1512559-37-3
NCIT ID C101895


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + Elgemtumab Alpelisib Elgemtumab 0 1
Alpelisib + Elgemtumab + Trastuzumab Alpelisib Elgemtumab Trastuzumab 0 1
Buparlisib + Elgemtumab Buparlisib Elgemtumab 0 0
Elgemtumab Elgemtumab 0 0
Elgemtumab + Neratinib Elgemtumab Neratinib 0 0
Elgemtumab + Trastuzumab Elgemtumab Trastuzumab 0 1

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