Drug Detail

Drug Name Buparlisib
Trade Name
Synonyms BKM-120|BKM120
Drug Descriptions

Buparlisib (BKM120) specifically inhibits class I PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, and may result in apoptotic activity and inhibition of cell proliferation (PMID: 22188813).

DrugClasses PI3K Inhibitor (Pan) 34

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1331852 + Buparlisib A-1331852 Buparlisib 0 0
Abiraterone + Buparlisib Abiraterone Buparlisib 1 0
Abiraterone + Buparlisib + Prednisone Abiraterone Buparlisib Prednisone 0 1
Aldoxorubicin + Buparlisib Aldoxorubicin Buparlisib 1 0
AZD4547 + Buparlisib AZD4547 Buparlisib 4 0
Bevacizumab + Buparlisib Bevacizumab Buparlisib 1 2
BGJ398 + Buparlisib BGJ398 Buparlisib 2 0
Binimetinib + Buparlisib Binimetinib Buparlisib 3 0
Binimetinib + Buparlisib + Encorafenib Binimetinib Buparlisib Encorafenib 0 1
BLZ945 + Buparlisib BLZ945 Buparlisib 1 0
BMS-777607 + Buparlisib BMS-777607 Buparlisib 0 0
Buparlisib Buparlisib 28 11
Buparlisib + Capecitabine Buparlisib Capecitabine 0 2
Buparlisib + Capecitabine + Lapatinib Buparlisib Capecitabine Lapatinib 0 1
Buparlisib + Capecitabine + Trastuzumab Buparlisib Capecitabine Trastuzumab 0 1
Buparlisib + Capmatinib Buparlisib Capmatinib 0 1
Buparlisib + Carboplatin Buparlisib Carboplatin 0 1
Buparlisib + Carboplatin + Paclitaxel Buparlisib Carboplatin Paclitaxel 0 1
Buparlisib + Carboplatin + Pemetrexed Buparlisib Carboplatin Pemetrexed 0 1
Buparlisib + Cetuximab Buparlisib Cetuximab 0 0
Buparlisib + Cisplatin Buparlisib Cisplatin 0 1
Buparlisib + Cisplatin + Etoposide Buparlisib Cisplatin Etoposide 0 1
Buparlisib + Cisplatin + Gemcitabine Buparlisib Cisplatin Gemcitabine 0 1
Buparlisib + Crizotinib Buparlisib Crizotinib 1 0
Buparlisib + Docetaxel Buparlisib Docetaxel 0 1
Buparlisib + Encorafenib Buparlisib Encorafenib 1 1
Buparlisib + Erlotinib Buparlisib Erlotinib 0 1
Buparlisib + Everolimus Buparlisib Everolimus 1 1
Buparlisib + Fulvestrant Buparlisib Fulvestrant 0 2
Buparlisib + Fulvestrant + Ribociclib Buparlisib Fulvestrant Ribociclib 0 1
Buparlisib + Ibrutinib Buparlisib Ibrutinib 3 2
Buparlisib + Lapatinib + Trastuzumab Buparlisib Lapatinib Trastuzumab 1 0
Buparlisib + Letrozole Buparlisib Letrozole 0 1
Buparlisib + Letrozole + Ribociclib Buparlisib Letrozole Ribociclib 0 1
Buparlisib + LJM716 Buparlisib LJM716 0 0
Buparlisib + Lomustine Buparlisib Lomustine 0 1
Buparlisib + Nab-paclitaxel Buparlisib Nab-paclitaxel 0 1
Buparlisib + Navitoclax Buparlisib Navitoclax 0 0
Buparlisib + Ofatumumab Buparlisib Ofatumumab 0 1
Buparlisib + Olaparib Buparlisib Olaparib 1 1
Buparlisib + Osimertinib Buparlisib Osimertinib 3 0
Buparlisib + Paclitaxel Buparlisib Paclitaxel 2 2
Buparlisib + Palbociclib Buparlisib Palbociclib 4 0
Buparlisib + Panitumumab Buparlisib Panitumumab 0 1
Buparlisib + Panobinostat Buparlisib Panobinostat 0 0
Buparlisib + Pertuzumab Buparlisib Pertuzumab 0 0
Buparlisib + Pertuzumab + Trastuzumab Buparlisib Pertuzumab Trastuzumab 1 0
Buparlisib + PU-H71 Buparlisib PU-H71 0 0
Buparlisib + Rituximab Buparlisib Rituximab 0 1
Buparlisib + Selumetinib Buparlisib Selumetinib 1 0
Buparlisib + Sonidegib Buparlisib Sonidegib 0 2
Buparlisib + Temozolomide Buparlisib Temozolomide 0 1
Buparlisib + Trametinib Buparlisib Trametinib 2 0
Buparlisib + Trastuzumab Buparlisib Trastuzumab 4 0
Buparlisib + Tyrphostin B42 Buparlisib Tyrphostin B42 0 0
Buparlisib + Vemurafenib Buparlisib Vemurafenib 1 1
Buparlisib + Venetoclax Buparlisib Venetoclax 0 0
Buparlisib + WEHI-539 Buparlisib WEHI-539 1 0


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