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Drug Name Panobinostat
Trade Name Farydak
Synonyms LBH589
Drug Descriptions

Farydak (panobinostat) is an HDAC inhibitor, which induces cell-cycle arrest and decreases growth of tumor cells (PMID: 18349321, PMID: 19671764, PMID: 27802904). Farydak (panobinostat) is FDA approved, in combination with Velcade (Bortezomib) and dexamethasone, for multiple myeloma (FDA.gov).

DrugClasses HDAC Inhibitor 37

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Panobinostat Azacitidine Panobinostat 0 0
Bortezomib + Dexamethasone + Elotuzumab + Panobinostat Bortezomib Dexamethasone Elotuzumab Panobinostat 0 1
Bortezomib + Dexamethasone + Lenalidomide + Panobinostat Bortezomib Dexamethasone Lenalidomide Panobinostat 0 2
Bortezomib + Dexamethasone + Panobinostat Bortezomib Dexamethasone Panobinostat 1 4
Bortezomib + Panobinostat Bortezomib Panobinostat 1 0
Buparlisib + Panobinostat Buparlisib Panobinostat 0 0
Busulfan + Gemcitabine + Melphalan + Panobinostat Busulfan Gemcitabine Melphalan Panobinostat 0 1
Carboplatin + Paclitaxel + Panobinostat Carboplatin Paclitaxel Panobinostat 1 0
Carfilzomib + Dexamethasone + Lenalidomide + Panobinostat Carfilzomib Dexamethasone Lenalidomide Panobinostat 0 1
Carfilzomib + Dexamethasone + Panobinostat Carfilzomib Dexamethasone Panobinostat 0 1
Carfilzomib + Panobinostat Carfilzomib Panobinostat 0 1
Cisplatin + Etoposide + Panobinostat + Radiotherapy Cisplatin Etoposide Panobinostat Radiotherapy 1 0
Cytarabine + Daunorubicin + Panobinostat Cytarabine Daunorubicin Panobinostat 0 1
Cytarabine + Fludarabine + Leucovorin + Panobinostat Cytarabine Fludarabine Leucovorin Panobinostat 0 1
Cytarabine + Panobinostat Cytarabine Panobinostat 1 0
Decitabine + Panobinostat + Temozolomide Decitabine Panobinostat Temozolomide 0 1
Dexamethasone + Ixazomib + Panobinostat Dexamethasone Ixazomib Panobinostat 0 1
Epirubicin + Panobinostat Epirubicin Panobinostat 1 0
Everolimus + Panobinostat Everolimus Panobinostat 0 4
JQ1 + Panobinostat JQ1 Panobinostat 0 0
Lapatinib + Panobinostat Lapatinib Panobinostat 1 0
Marizomib + Panobinostat Marizomib Panobinostat 1 1
Panobinostat Panobinostat 2 11
Panobinostat + Pazopanib Panobinostat Pazopanib 0 1
Panobinostat + PQR309 PQR309 Panobinostat 1 0
Panobinostat + Radiotherapy Panobinostat Radiotherapy 1 0
Panobinostat + SCH772984 Panobinostat SCH772984 0 0
Panobinostat + Sorafenib Panobinostat Sorafenib 0 1
Panobinostat + Spartalizumab Panobinostat Spartalizumab 0 1
Panobinostat + WP1066 Panobinostat WP1066 0 0


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