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Drug Name Tazemetostat
Trade Name Tazverik
Synonyms EPZ6438|E-7438|EPZ-6438
Drug Descriptions

Tazverik (tazemetostat) binds to and inhibits EZH2, resulting in decreased tri-methylation of H3K27, and potentially leading to inhibition of cell proliferation and tumor growth (PMID: 23620515). Tazverik (tazemetostat) is FDA approved for use in patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection, and in adult patients with relapsed or refractory follicular lymphoma (R/R FL) harboring an EZH2 mutation after 2 prior therapies, and in patients with R/R FL without treatment options (FDA.gov).

DrugClasses EZH2 inhibitor 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Prednisone + Tazemetostat Abiraterone Prednisone Tazemetostat 0 1
Doxorubicin + Tazemetostat Doxorubicin Tazemetostat 0 1
Enzalutamide + Tazemetostat Enzalutamide Tazemetostat 0 1
Everolimus + Tazemetostat Everolimus Tazemetostat 1 0
Fluconazole + Tazemetostat Fluconazole Tazemetostat 0 1
Ibrutinib + Tazemetostat Ibrutinib Tazemetostat 1 0
Idelalisib + Tazemetostat Idelalisib Tazemetostat 1 0
LAM-003 + Tazemetostat LAM-003 Tazemetostat 1 0
Lenalidomide + Rituximab + Tazemetostat Lenalidomide Rituximab Tazemetostat 0 1
MK2206 + Tazemetostat MK2206 Tazemetostat 1 0
Nilotinib + Tazemetostat Nilotinib Tazemetostat 1 0
Omeprazole + Repaglinide + Tazemetostat Omeprazole Repaglinide Tazemetostat 0 1
Pembrolizumab + Tazemetostat Pembrolizumab Tazemetostat 0 1
Selumetinib + Tazemetostat Selumetinib Tazemetostat 0 0
Tamatinib + Tazemetostat Tamatinib Tazemetostat 1 0
Tazemetostat Tazemetostat 49 9
Tazemetostat + Trametinib Tazemetostat Trametinib 1 0


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