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Drug Name Ipilimumab
Trade Name Yervoy
Synonyms BMS-734016
Drug Descriptions

Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).

DrugClasses CTLA4 Antibody 16 Immune Checkpoint Inhibitor 95

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ad.p53-DC vaccine + Ipilimumab + Nivolumab Ad.p53-DC vaccine Ipilimumab Nivolumab 0 1
ADI-PEG 20 + Ipilimumab + Nivolumab ADI-PEG 20 Ipilimumab Nivolumab 0 1
Aldesleukin + Cyclophosphamide + Ipilimumab Aldesleukin Cyclophosphamide Ipilimumab 0 1
Aldesleukin + Ipilimumab Aldesleukin Ipilimumab 0 1
ALT-803 + CIML-NK cells + Ipilimumab ALT-803 CIML-NK cells Ipilimumab 0 1
ALT-803 + Ipilimumab ALT-803 Ipilimumab 0 0
Anetumab ravtansine + Ipilimumab + Nivolumab Anetumab ravtansine Ipilimumab Nivolumab 0 1
Anti-IL13RA2 CAR T cells + Ipilimumab + Nivolumab Anti-IL13RA2 CAR T cells Ipilimumab Nivolumab 0 1
Atezolizumab + Ipilimumab Atezolizumab Ipilimumab 0 1
Bevacizumab + Ipilimumab Bevacizumab Ipilimumab 0 1
Bicalutamide + Ipilimumab + Nivolumab Bicalutamide Ipilimumab Nivolumab 0 1
Binimetinib + Ipilimumab + Nivolumab Binimetinib Ipilimumab Nivolumab 0 1
Blinatumomab + Ipilimumab + Nivolumab Blinatumomab Ipilimumab Nivolumab 0 1
BMS-986156 + Ipilimumab + Nivolumab BMS-986156 Ipilimumab Nivolumab 0 1
BMS-986205 + Ipilimumab + Nivolumab BMS-986205 Ipilimumab Nivolumab 0 1
BMS-986226 + Ipilimumab BMS-986226 Ipilimumab 0 1
BMS-986299 + Ipilimumab + Nivolumab BMS-986299 Ipilimumab Nivolumab 0 1
Brentuximab vedotin + Ipilimumab Brentuximab vedotin Ipilimumab 0 1
Cabozantinib + Ipilimumab + Nivolumab Cabozantinib Ipilimumab Nivolumab 0 10
Carboplatin + Ipilimumab + Nivolumab + Paclitaxel Carboplatin Ipilimumab Nivolumab Paclitaxel 0 1
Carboplatin + Ipilimumab + Nivolumab + Pemetrexed Disodium Carboplatin Ipilimumab Nivolumab Pemetrexed Disodium 0 0
Carboplatin + Ipilimumab + Paclitaxel Carboplatin Ipilimumab Paclitaxel 0 1
CBM588 + Ipilimumab + Nivolumab CBM588 Ipilimumab Nivolumab 0 1
CD24Fc + Ipilimumab + Nivolumab CD24Fc Ipilimumab Nivolumab 0 1
Cemiplimab + Ipilimumab Cemiplimab Ipilimumab 0 4
Cetuximab + Ipilimumab Cetuximab Ipilimumab 0 1
Cisplatin + Etoposide + Ipilimumab Cisplatin Etoposide Ipilimumab 0 1
Cisplatin + Ipilimumab + Nivolumab + Pemetrexed Disodium Cisplatin Ipilimumab Nivolumab Pemetrexed Disodium 0 0
Cisplatin + Ipilimumab + Pemetrexed Disodium Cisplatin Ipilimumab Pemetrexed Disodium 0 1
Citarinostat + Ipilimumab + Nivolumab Citarinostat Ipilimumab Nivolumab 0 2
Cobimetinib + Ipilimumab + Nivolumab Cobimetinib Ipilimumab Nivolumab 0 1
Copanlisib + Ipilimumab + Nivolumab Copanlisib Ipilimumab Nivolumab 0 1
Coxsackievirus A21 + Ipilimumab Coxsackievirus A21 Ipilimumab 0 1
CPI-1205 + Ipilimumab CPI-1205 Ipilimumab 0 1
Crizotinib + Ipilimumab Crizotinib Ipilimumab 0 1
CRS-207 + Cyclophosphamide + GVAX pancreatic cancer vaccine + Ipilimumab + Nivolumab CRS-207 Cyclophosphamide GVAX pancreatic cancer vaccine Ipilimumab Nivolumab 0 1
CRS-207 + Ipilimumab + Nivolumab CRS-207 Ipilimumab Nivolumab 0 1
CX-072 + Ipilimumab CX-072 Ipilimumab 1 1
Cyclophosphamide + Interferon alpha-2b + Ipilimumab + SV-BR-1-GM Cyclophosphamide Interferon alpha-2b Ipilimumab SV-BR-1-GM 0 1
Cyclophosphamide + Ipilimumab + Nivolumab Cyclophosphamide Ipilimumab Nivolumab 0 1
Dabrafenib + Ipilimumab Dabrafenib Ipilimumab 0 2
Dabrafenib + Ipilimumab + Trametinib Dabrafenib Ipilimumab Trametinib 0 1
Dactinomycin + Ipilimumab + Melphalan Dactinomycin Ipilimumab Melphalan 0 1
Dasatinib + Ipilimumab Dasatinib Ipilimumab 0 1
Decitabine + Ipilimumab Decitabine Ipilimumab 0 1
DNAJB1-PRKACA peptide vaccine + Ipilimumab + MUC1 peptide-Poly-ICLC vaccine + Nivolumab DNAJB1-PRKACA peptide vaccine Ipilimumab MUC1 peptide-Poly-ICLC vaccine Nivolumab 0 0
DNAJB1-PRKACA peptide vaccine + Ipilimumab + Nivolumab + Poly ICLC DNAJB1-PRKACA peptide vaccine Ipilimumab Nivolumab Poly ICLC 0 1
DS-3201b + Ipilimumab DS-3201b Ipilimumab 0 1
Entinostat + Ipilimumab + Nivolumab Entinostat Ipilimumab Nivolumab 0 2
Epacadostat + Ipilimumab + Nivolumab Epacadostat Ipilimumab Nivolumab 0 1
Erlotinib + Ipilimumab Erlotinib Ipilimumab 0 1
Evofosfamide + Ipilimumab Evofosfamide Ipilimumab 0 1
Fluorouracil + Ipilimumab + Nivolumab Fluorouracil Ipilimumab Nivolumab 0 1
Gemcitabine + Ipilimumab Gemcitabine Ipilimumab 0 1
GNOS-PV01 + INO-9012 + Ipilimumab + Nivolumab GNOS-PV01 INO-9012 Ipilimumab Nivolumab 0 1
GRT-C901 + GRT-R902 + Ipilimumab + Nivolumab GRT-C901 GRT-R902 Ipilimumab Nivolumab 0 1
GRT-C903 + GRT-R904 + Ipilimumab + Nivolumab GRT-C903 GRT-R904 Ipilimumab Nivolumab 0 1
GVAX + Ipilimumab + Nivolumab GVAX Ipilimumab Nivolumab 0 1
HF10 + Ipilimumab HF10 Ipilimumab 0 1
hu14.18-IL2 + Ipilimumab + Nivolumab Ipilimumab Nivolumab hu14.18-IL2 0 1
Imatinib + Ipilimumab Imatinib Ipilimumab 0 1
IMO-2125 + Ipilimumab IMO-2125 Ipilimumab 0 2
IMO-2125 + Ipilimumab + Nivolumab IMO-2125 Ipilimumab Nivolumab 0 1
INCAGN01876 + Ipilimumab INCAGN01876 Ipilimumab 0 1
INCAGN01876 + Ipilimumab + Nivolumab INCAGN01876 Ipilimumab Nivolumab 0 1
INCAGN01949 + Ipilimumab INCAGN01949 Ipilimumab 0 1
INCAGN01949 + Ipilimumab + Nivolumab INCAGN01949 Ipilimumab Nivolumab 0 1
Ipilimumab Ipilimumab 5 85
Ipilimumab + Lefitolimod Ipilimumab Lefitolimod 0 1
Ipilimumab + Lenalidomide Ipilimumab Lenalidomide 0 2
Ipilimumab + MGA271 Ipilimumab MGA271 0 1
Ipilimumab + MIW815 Ipilimumab MIW815 0 1
Ipilimumab + Mocetinostat + Nivolumab Ipilimumab Mocetinostat Nivolumab 0 1
Ipilimumab + Nab-paclitaxel Ipilimumab Nab-paclitaxel 0 1
Ipilimumab + Nab-paclitaxel + Nivolumab Ipilimumab Nab-paclitaxel Nivolumab 0 1
Ipilimumab + NEO-PV-01 + Nivolumab + Poly ICLC Ipilimumab NEO-PV-01 Nivolumab Poly ICLC 0 1
Ipilimumab + NeoVax Ipilimumab NeoVax 0 1
Ipilimumab + NeoVax + Nivolumab Ipilimumab NeoVax Nivolumab 0 2
Ipilimumab + Nintedanib + Nivolumab Ipilimumab Nintedanib Nivolumab 0 1
Ipilimumab + Niraparib Ipilimumab Niraparib 0 1
Ipilimumab + Nivolumab Ipilimumab Nivolumab 8 142
Ipilimumab + Nivolumab + Oxaliplatin Ipilimumab Nivolumab Oxaliplatin 0 1
Ipilimumab + Nivolumab + Paclitaxel Ipilimumab Nivolumab Paclitaxel 0 1
Ipilimumab + Nivolumab + Panitumumab Ipilimumab Nivolumab Panitumumab 0 1
Ipilimumab + Nivolumab + Plinabulin Ipilimumab Nivolumab Plinabulin 0 1
Ipilimumab + Nivolumab + Poly ICLC Ipilimumab Nivolumab Poly ICLC 0 1
Ipilimumab + Nivolumab + Prednisone + Tacrolimus Ipilimumab Nivolumab Prednisone Tacrolimus 0 1
Ipilimumab + Nivolumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM Ipilimumab Nivolumab PROSTVAC-F/TRICOM PROSTVAC-V/TRICOM 0 2
Ipilimumab + Nivolumab + PROSTVAC-V/TRICOM Ipilimumab Nivolumab PROSTVAC-V/TRICOM 0 0
Ipilimumab + Nivolumab + Regorafenib Ipilimumab Nivolumab Regorafenib 0 1
Ipilimumab + Nivolumab + Relatlimab Ipilimumab Nivolumab Relatlimab 0 1
Ipilimumab + Nivolumab + rhIL-15 Ipilimumab Nivolumab rhIL-15 0 1
Ipilimumab + Nivolumab + rHuPH20 Ipilimumab Nivolumab rHuPH20 0 1
Ipilimumab + Nivolumab + Rituximab Ipilimumab Nivolumab Rituximab 0 1
Ipilimumab + Nivolumab + Rovalpituzumab Tesirine Ipilimumab Nivolumab Rovalpituzumab Tesirine 0 1
Ipilimumab + Nivolumab + Sargramostim + UV1 Telomerase peptide vaccine Ipilimumab Nivolumab Sargramostim UV1 Telomerase peptide vaccine 0 1
Ipilimumab + Nivolumab + Talimogene laherparepvec Ipilimumab Nivolumab Talimogene laherparepvec 0 1
Ipilimumab + Nivolumab + Tocilizumab Ipilimumab Nivolumab Tocilizumab 0 1
Ipilimumab + Nivolumab + TP-1454 Ipilimumab Nivolumab TP-1454 0 1
Ipilimumab + Nivolumab + Trabectedin Ipilimumab Nivolumab Trabectedin 0 1
Ipilimumab + Nivolumab + Trametinib Ipilimumab Nivolumab Trametinib 0 1
Ipilimumab + Nivolumab + Vedolizumab Ipilimumab Nivolumab Vedolizumab 0 1
Ipilimumab + Nivolumab + VX15/2503 Ipilimumab Nivolumab VX15/2503 0 1
Ipilimumab + Nivolumab + Yttrium-90 Ipilimumab Nivolumab Yttrium-90 0 1
Ipilimumab + NY-ESO-1 peptide vaccine Ipilimumab NY-ESO-1 peptide vaccine 0 0
Ipilimumab + Pembrolizumab Ipilimumab Pembrolizumab 1 5
Ipilimumab + Pexmetinib Ipilimumab Pexmetinib 0 1
Ipilimumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM Ipilimumab PROSTVAC-F/TRICOM PROSTVAC-V/TRICOM 0 2
Ipilimumab + PROSTVAC-V/TRICOM Ipilimumab PROSTVAC-V/TRICOM 0 0
Ipilimumab + Radiotherapy Ipilimumab Radiotherapy 1 0
Ipilimumab + Relatlimab Ipilimumab Relatlimab 0 1
Ipilimumab + rhIL-15 Ipilimumab rhIL-15 0 1
Ipilimumab + Sargramostim + UV1 Telomerase peptide vaccine Ipilimumab Sargramostim UV1 Telomerase peptide vaccine 1 0
Ipilimumab + SD-101 Ipilimumab SD-101 0 1
Ipilimumab + Vopratelimab Ipilimumab Vopratelimab 0 2
Ipilimumab + VX15/2503 Ipilimumab VX15/2503 0 4


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