Drug Detail

Drug Name Epacadostat
Trade Name
Synonyms INCB024360
Drug Descriptions

Epacadostat (INCB024360) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 20197554).

DrugClasses IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99

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Therapy Name Therapy Description
INCB024360 + Nivolumab + mFOLFOX6
Epacadostat + INCAGN01876 + Pembrolizumab
CRS-207 + Cyclophosphamide + GVAX panc vaccine + INCB024360 + Pembrolizumab
INCB039110 + INCB024360
Atezolizumab + Epacadostat
ALT-803 + Epacadostat + FPV-Brachyury + MVA-BN-Brachyury + M7824
INCB024360 + MEDI4736
INCB024360 + Pembrolizumab + Carboplatin + Paclitaxel
Cyclophosphamide + DPX-Survivac + INCB024360
INCB024360 + Pembrolizumab + Cyclophosphamide
Epacadostat + Ipilimumab + Nivolumab
Carboplatin + Cisplatin + Epacadostat + Gemzar + Nivolumab + Taxol + Pemetrexed
Epacadostat + INCB001158
Carboplatin + Cisplatin + Epacadostat + Fluorouracil + Nivolumab
Epacadostat + Pembrolizumab + Tavokinogene telseplasmid Tavokinogene telseplasmid is a plasmid encoding IL-12, which can delivered intratumorally by electroporation, potentially resulting in increased anti-tumor immune response (PMID: 29064334).
CRS-207 + INCB024360 + Pembrolizumab
Epacadostat + Pembrolizumab
Azacitidine + INCB024360 + Pembrolizumab
INCB024360 + Nivolumab
INCB024360 + Nivolumab + Gemcitabine + nab-paclitaxel
Epacadostat + SD-101
Epacadostat + INCMGA00012
INCB024360 + Pembrolizumab + Carboplatin + Pemetrexed
Epacadostat + Lirilumab + Nivolumab
Epacadostat Epacadostat (INCB024360) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 20197554).
Epacadostat + INCB001158 + Pembrolizumab
Epacadostat + Sirolimus
Avelumab + Bevacizumab + Epacadostat