Drug Detail

Drug Name Epacadostat
Trade Name
Synonyms INCB024360
Drug Descriptions

Epacadostat (INCB024360) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 20197554).

DrugClasses IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ALT-803 + Epacadostat + FPV-Brachyury + M7824 + MVA-BN-Brachyury ALT-803 Epacadostat FPV-Brachyury M7824 MVA-BN-Brachyury 0 1
Atezolizumab + Epacadostat Atezolizumab Epacadostat 0 1
Avelumab + Bevacizumab + Epacadostat Avelumab Bevacizumab Epacadostat 0 1
Azacitidine + Epacadostat + Pembrolizumab Azacitidine Epacadostat Pembrolizumab 0 1
Carboplatin + Cisplatin + Epacadostat + Fluorouracil + Nivolumab Carboplatin Cisplatin Epacadostat Fluorouracil Nivolumab 0 1
Carboplatin + Cisplatin + Epacadostat + Gemcitabine + Nivolumab + Paclitaxel + Pemetrexed Carboplatin Cisplatin Epacadostat Gemcitabine Nivolumab Paclitaxel Pemetrexed 0 1
Carboplatin + Epacadostat + Paclitaxel + Pembrolizumab Carboplatin Epacadostat Paclitaxel Pembrolizumab 0 1
Carboplatin + Epacadostat + Pembrolizumab + Pemetrexed Carboplatin Epacadostat Pembrolizumab Pemetrexed 0 1
CRS-207 + Cyclophosphamide + Epacadostat + GVAX pancreatic cancer vaccine + Pembrolizumab CRS-207 Cyclophosphamide Epacadostat GVAX pancreatic cancer vaccine Pembrolizumab 0 1
CRS-207 + Epacadostat + Pembrolizumab CRS-207 Epacadostat Pembrolizumab 0 1
Cyclophosphamide + DPX-Survivac + Epacadostat Cyclophosphamide DPX-Survivac Epacadostat 0 1
Cyclophosphamide + Epacadostat + Pembrolizumab Cyclophosphamide Epacadostat Pembrolizumab 0 1
Durvalumab + Epacadostat Durvalumab Epacadostat 0 1
Epacadostat Epacadostat 2 7
Epacadostat + Fluorouracil + Leucovorin + Nivolumab + Oxaliplatin Epacadostat Fluorouracil Leucovorin Nivolumab Oxaliplatin 0 1
Epacadostat + Gemcitabine + Nab-paclitaxel + Nivolumab Epacadostat Gemcitabine Nab-paclitaxel Nivolumab 0 1
Epacadostat + INCAGN01876 + Pembrolizumab Epacadostat INCAGN01876 Pembrolizumab 0 1
Epacadostat + INCB001158 Epacadostat INCB001158 0 1
Epacadostat + INCB001158 + Pembrolizumab Epacadostat INCB001158 Pembrolizumab 0 1
Epacadostat + INCMGA00012 Epacadostat INCMGA00012 0 1
Epacadostat + Ipilimumab + Nivolumab Epacadostat Ipilimumab Nivolumab 0 1
Epacadostat + Itacitinib Epacadostat Itacitinib 0 1
Epacadostat + Lirilumab + Nivolumab Epacadostat Lirilumab Nivolumab 0 1
Epacadostat + Nivolumab Epacadostat Nivolumab 0 2
Epacadostat + Pembrolizumab Epacadostat Pembrolizumab 2 19
Epacadostat + Pembrolizumab + Tavokinogene telseplasmid Epacadostat Pembrolizumab Tavokinogene telseplasmid 0 1
Epacadostat + SD-101 Epacadostat SD-101 0 1
Epacadostat + Sirolimus Epacadostat Sirolimus 0 1


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