Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Durvalumab
Trade Name Imfinzi
Synonyms MEDI4736
Drug Descriptions

Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, and in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 95 PD-L1/PD-1 antibody 63

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Durvalumab Abemaciclib Anastrozole Durvalumab 0 1
Abemaciclib + Durvalumab + Exemestane Abemaciclib Durvalumab Exemestane 0 1
Abemaciclib + Durvalumab + Letrozole Abemaciclib Durvalumab Letrozole 0 1
Adavosertib + Durvalumab Adavosertib Durvalumab 0 2
Aldoxorubicin + Durvalumab + Motolimod Aldoxorubicin Durvalumab Motolimod 0 1
Anastrozole + Durvalumab Anastrozole Durvalumab 0 1
AVB-S6-500 + Durvalumab AVB-S6-500 Durvalumab 0 1
Azacitidine + Durvalumab Azacitidine Durvalumab 0 5
Azacitidine + Durvalumab + Romidepsin Azacitidine Durvalumab Romidepsin 0 1
Azacitidine + Durvalumab + Tremelimumab Azacitidine Durvalumab Tremelimumab 0 1
AZD4547 + Durvalumab AZD4547 Durvalumab 0 1
AZD4635 + Durvalumab AZD4635 Durvalumab 0 2
AZD5069 + Durvalumab AZD5069 Durvalumab 0 2
AZD6738 + Durvalumab AZD6738 Durvalumab 0 2
AZD9150 + Carboplatin + Durvalumab AZD9150 Carboplatin Durvalumab 0 0
AZD9150 + Carboplatin + Durvalumab + Gemcitabine AZD9150 Carboplatin Durvalumab Gemcitabine 0 1
AZD9150 + Carboplatin + Durvalumab + Nab-paclitaxel AZD9150 Carboplatin Durvalumab Nab-paclitaxel 0 1
AZD9150 + Cisplatin + Durvalumab AZD9150 Cisplatin Durvalumab 0 0
AZD9150 + Cisplatin + Durvalumab + Fluorouracil AZD9150 Cisplatin Durvalumab Fluorouracil 0 1
AZD9150 + Cisplatin + Durvalumab + Gemcitabine AZD9150 Cisplatin Durvalumab Gemcitabine 0 1
AZD9150 + Durvalumab AZD9150 Durvalumab 0 8
AZD9150 + Durvalumab + Gemcitabine AZD9150 Durvalumab Gemcitabine 0 0
AZD9150 + Durvalumab + Nab-paclitaxel AZD9150 Durvalumab Nab-paclitaxel 0 0
AZD9150 + Durvalumab + Paclitaxel AZD9150 Durvalumab Paclitaxel 0 1
AZD9150 + Durvalumab + Pemetrexed AZD9150 Durvalumab Pemetrexed 0 0
BCG solution + Durvalumab BCG solution Durvalumab 0 2
Bendamustine + Durvalumab + Rituximab Bendamustine Durvalumab Rituximab 0 1
Bevacizumab + Capecitabine + CV301 + Durvalumab Bevacizumab CV301 Capecitabine Durvalumab 0 1
Bevacizumab + Carboplatin + Durvalumab + Paclitaxel Bevacizumab Carboplatin Durvalumab Paclitaxel 0 1
Bevacizumab + Doxorubicin + Durvalumab Bevacizumab Doxorubicin Durvalumab 0 1
Bevacizumab + Durvalumab Bevacizumab Durvalumab 0 4
Bevacizumab + Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin + Tremelimumab Bevacizumab Durvalumab Fluorouracil Leucovorin Oxaliplatin Tremelimumab 0 1
Bevacizumab + Durvalumab + Olaparib Bevacizumab Durvalumab Olaparib 0 2
Bevacizumab + Durvalumab + Tremelimumab Bevacizumab Durvalumab Tremelimumab 0 0
BI 1361849 + Durvalumab + Tremelimumab BI 1361849 Durvalumab Tremelimumab 0 1
Cabozantinib + Durvalumab Cabozantinib Durvalumab 0 1
Capecitabine + CV301 + Durvalumab CV301 Capecitabine Durvalumab 0 1
Capecitabine + Durvalumab Capecitabine Durvalumab 0 1
Capecitabine + Durvalumab + Fam-trastuzumab deruxtecan-nxki Capecitabine Durvalumab Fam-trastuzumab deruxtecan-nxki 0 1
Capivasertib + Durvalumab + Paclitaxel Capivasertib Durvalumab Paclitaxel 0 1
Carboplatin + Cisplatin + Durvalumab + Etoposide Carboplatin Cisplatin Durvalumab Etoposide 0 2
Carboplatin + Cisplatin + Durvalumab + Etoposide + Tremelimumab Carboplatin Cisplatin Durvalumab Etoposide Tremelimumab 0 2
Carboplatin + Cisplatin + Durvalumab + Paclitaxel Carboplatin Cisplatin Durvalumab Paclitaxel 0 1
Carboplatin + Cisplatin + Durvalumab + Pemetrexed Carboplatin Cisplatin Durvalumab Pemetrexed 0 1
Carboplatin + Durvalumab Carboplatin Durvalumab 0 2
Carboplatin + Durvalumab + Etoposide Carboplatin Durvalumab Etoposide 1 2
Carboplatin + Durvalumab + Etoposide + Tremelimumab Carboplatin Durvalumab Etoposide Tremelimumab 0 2
Carboplatin + Durvalumab + Gemcitabine Carboplatin Durvalumab Gemcitabine 0 3
Carboplatin + Durvalumab + Gemcitabine + Tremelimumab Carboplatin Durvalumab Gemcitabine Tremelimumab 0 2
Carboplatin + Durvalumab + Nab-paclitaxel Carboplatin Durvalumab Nab-paclitaxel 0 1
Carboplatin + Durvalumab + Nab-paclitaxel + Tremelimumab Carboplatin Durvalumab Nab-paclitaxel Tremelimumab 0 1
Carboplatin + Durvalumab + Oleclumab Carboplatin Durvalumab Oleclumab 0 0
Carboplatin + Durvalumab + Paclitaxel Carboplatin Durvalumab Paclitaxel 0 8
Carboplatin + Durvalumab + Paclitaxel + Tremelimumab Carboplatin Durvalumab Paclitaxel Tremelimumab 0 1
Carboplatin + Durvalumab + Pemetrexed Carboplatin Durvalumab Pemetrexed 0 4
Cediranib + Durvalumab Cediranib Durvalumab 1 2
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 1 0
Cetuximab + Durvalumab Cetuximab Durvalumab 0 1
Cisplatin + Docetaxel + Durvalumab Cisplatin Docetaxel Durvalumab 0 1
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Vinblastine 0 1
Cisplatin + Durvalumab Cisplatin Durvalumab 0 2
Cisplatin + Durvalumab + Etoposide Cisplatin Durvalumab Etoposide 1 3
Cisplatin + Durvalumab + Fluorouracil + Tremelimumab Cisplatin Durvalumab Fluorouracil Tremelimumab 0 1
Cisplatin + Durvalumab + Gemcitabine Cisplatin Durvalumab Gemcitabine 0 6
Cisplatin + Durvalumab + Gemcitabine + Tremelimumab Cisplatin Durvalumab Gemcitabine Tremelimumab 0 1
Cisplatin + Durvalumab + Oleclumab Cisplatin Durvalumab Oleclumab 0 0
Cisplatin + Durvalumab + Pemetrexed Cisplatin Durvalumab Pemetrexed 0 6
Copanlisib + Durvalumab + Olaparib Copanlisib Durvalumab Olaparib 0 1
Cyclophosphamide + Doxorubicin + Durvalumab + Lenalidomide + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Durvalumab Lenalidomide Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Doxorubicin + Durvalumab + Prednisone + Rituximab + Vincristine Cyclophosphamide Doxorubicin Durvalumab Prednisone Rituximab Vincristine 0 1
Cyclophosphamide + Durvalumab + JCAR014 Cyclophosphamide Durvalumab JCAR014 0 1
Cyclophosphamide + Durvalumab + Tremelimumab Cyclophosphamide Durvalumab Tremelimumab 0 1
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Daratumumab + Dexamethasone + Durvalumab + Pomalidomide Daratumumab Dexamethasone Durvalumab Pomalidomide 0 1
Daratumumab + Durvalumab Daratumumab Durvalumab 0 2
DC/AML Vaccine + Durvalumab DC/AML Vaccine Durvalumab 0 1
Durvalumab Durvalumab 6 120
Durvalumab + Ensartinib Durvalumab Ensartinib 0 1
Durvalumab + Epacadostat Durvalumab Epacadostat 0 2
Durvalumab + Eribulin Durvalumab Eribulin 0 1
Durvalumab + Exemestane Durvalumab Exemestane 0 1
Durvalumab + Fam-trastuzumab deruxtecan-nxki Durvalumab Fam-trastuzumab deruxtecan-nxki 0 1
Durvalumab + Fam-trastuzumab deruxtecan-nxki + Fluorouracil Durvalumab Fam-trastuzumab deruxtecan-nxki Fluorouracil 0 1
Durvalumab + FANG vaccine Durvalumab FANG vaccine 0 1
Durvalumab + Fluorouracil + Leucovorin + Monalizumab + Oxaliplatin Durvalumab Fluorouracil Leucovorin Monalizumab Oxaliplatin 0 1
Durvalumab + Fluorouracil + Leucovorin + Oleclumab + Oxaliplatin Durvalumab Fluorouracil Leucovorin Oleclumab Oxaliplatin 0 2
Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin Durvalumab Fluorouracil Leucovorin Oxaliplatin 0 1
Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin + Tremelimumab Durvalumab Fluorouracil Leucovorin Oxaliplatin Tremelimumab 0 1
Durvalumab + Galunisertib Durvalumab Galunisertib 0 1
Durvalumab + Gefitinib Durvalumab Gefitinib 0 1
Durvalumab + Gemcitabine Durvalumab Gemcitabine 0 1
Durvalumab + Gemcitabine + Nab-paclitaxel Durvalumab Gemcitabine Nab-paclitaxel 0 1
Durvalumab + Gemcitabine + Nab-paclitaxel + Oleclumab Durvalumab Gemcitabine Nab-paclitaxel Oleclumab 0 1
Durvalumab + Gemcitabine + Nab-paclitaxel + Tremelimumab Durvalumab Gemcitabine Nab-paclitaxel Tremelimumab 0 1
Durvalumab + Gemcitabine + Oleclumab Durvalumab Gemcitabine Oleclumab 0 0
Durvalumab + Guadecitabine Durvalumab Guadecitabine 0 2
Durvalumab + Guadecitabine + Tremelimumab Durvalumab Guadecitabine Tremelimumab 0 1
Durvalumab + Ibrutinib Durvalumab Ibrutinib 0 3
Durvalumab + IPH5201 Durvalumab IPH5201 0 1
Durvalumab + IPH5201 + Oleclumab Durvalumab IPH5201 Oleclumab 0 1
Durvalumab + IPH5401 Durvalumab IPH5401 0 1
Durvalumab + JCAR017 Durvalumab JCAR017 0 1
Durvalumab + Lenalidomide Durvalumab Lenalidomide 0 2
Durvalumab + Lenalidomide + PVX-410 Durvalumab Lenalidomide PVX-410 0 1
Durvalumab + Lenalidomide + Rituximab Durvalumab Lenalidomide Rituximab 0 1
Durvalumab + Letrozole Durvalumab Letrozole 0 1
Durvalumab + LN-145 Durvalumab LN-145 0 1
Durvalumab + Loncastuximab tesirine Durvalumab Loncastuximab tesirine 0 1
Durvalumab + LY2510924 Durvalumab LY2510924 0 1
Durvalumab + LY3022855 Durvalumab LY3022855 0 1
Durvalumab + MEDI0457 Durvalumab MEDI0457 0 3
Durvalumab + MEDI0680 Durvalumab MEDI0680 0 1
Durvalumab + MEDI1191 Durvalumab MEDI1191 0 1
Durvalumab + MEDI5083 Durvalumab MEDI5083 0 1
Durvalumab + MEDI5395 Durvalumab MEDI5395 0 1
Durvalumab + MEDI9090 Durvalumab MEDI9090 0 1
Durvalumab + MEDI9197 Durvalumab MEDI9197 0 1
Durvalumab + Metformin Durvalumab Metformin 0 1
Durvalumab + Mocetinostat Durvalumab Mocetinostat 0 2
Durvalumab + Monalizumab Durvalumab Monalizumab 0 2
Durvalumab + mRNA-2752 Durvalumab mRNA-2752 0 1
Durvalumab + Nab-paclitaxel Durvalumab Nab-paclitaxel 0 2
Durvalumab + Nab-paclitaxel + Oleclumab Durvalumab Nab-paclitaxel Oleclumab 0 0
Durvalumab + Olaparib Durvalumab Olaparib 2 14
Durvalumab + Olaparib + Tremelimumab Durvalumab Olaparib Tremelimumab 0 1
Durvalumab + Oleclumab Durvalumab Oleclumab 0 6
Durvalumab + Oleclumab + Paclitaxel Durvalumab Oleclumab Paclitaxel 0 1
Durvalumab + Oleclumab + Pemetrexed Durvalumab Oleclumab Pemetrexed 0 0
Durvalumab + ONCOS-102 Durvalumab ONCOS-102 0 1
Durvalumab + Oportuzumab monatox Durvalumab Oportuzumab monatox 0 1
Durvalumab + Osimertinib Durvalumab Osimertinib 0 1
Durvalumab + Paclitaxel Durvalumab Paclitaxel 0 2
Durvalumab + Paclitaxel + Selumetinib Durvalumab Paclitaxel Selumetinib 0 1
Durvalumab + Pegylated liposomal-doxorubicin Durvalumab Pegylated liposomal-doxorubicin 0 1
Durvalumab + Pemetrexed Durvalumab Pemetrexed 0 1
Durvalumab + Personalized cancer vaccine + Tremelimumab Durvalumab Personalized cancer vaccine Tremelimumab 0 1
Durvalumab + Pertuzumab + Trastuzumab Durvalumab Pertuzumab Trastuzumab 0 1
Durvalumab + Poly ICLC Durvalumab Poly ICLC 0 2
Durvalumab + Poly ICLC + PVX-410 Durvalumab PVX-410 Poly ICLC 0 1
Durvalumab + Pralatrexate + Romidepsin Durvalumab Pralatrexate Romidepsin 0 1
Durvalumab + Prednisone Durvalumab Prednisone 0 1
Durvalumab + PVX-410 Durvalumab PVX-410 0 1
Durvalumab + Ramucirumab Durvalumab Ramucirumab 0 1
Durvalumab + Romidepsin Durvalumab Romidepsin 0 1
Durvalumab + Selumetinib Durvalumab Selumetinib 0 3
Durvalumab + Selumetinib + Tremelimumab Durvalumab Selumetinib Tremelimumab 0 1
Durvalumab + Sirolimus Durvalumab Sirolimus 0 1
Durvalumab + SNDX-6352 Durvalumab SNDX-6352 0 2
Durvalumab + Tavolimab Durvalumab Tavolimab 0 1
Durvalumab + Tivozanib Durvalumab Tivozanib 0 1
Durvalumab + TPIV 200 Durvalumab TPIV 200 0 1
Durvalumab + Trabectedin Durvalumab Trabectedin 0 1
Durvalumab + Trametinib Durvalumab Trametinib 0 2
Durvalumab + Trastuzumab Durvalumab Trastuzumab 0 1
Durvalumab + Tremelimumab Durvalumab Tremelimumab 2 65
Durvalumab + Vistusertib Durvalumab Vistusertib 0 2


Additional content available in CKB BOOST