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Drug Name Durvalumab
Trade Name Imfinzi
Synonyms MEDI4736
Drug Descriptions

Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, and in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer (FDA.gov).
DrugClasses Immune Checkpoint Inhibitor 148 PD-L1/PD-1 antibody 93
CAS Registry Number 1428935-60-7
NCIT ID C103194

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AB154 + Durvalumab AB154 Durvalumab 0 1
Abemaciclib + Anastrozole + Durvalumab Abemaciclib Anastrozole Durvalumab 0 1
Abemaciclib + Durvalumab + Exemestane Abemaciclib Durvalumab Exemestane 0 1
Abemaciclib + Durvalumab + Letrozole Abemaciclib Durvalumab Letrozole 0 1
Acalabrutinib + Durvalumab Acalabrutinib Durvalumab 0 1
Acalabrutinib + Durvalumab + Venetoclax Acalabrutinib Durvalumab Venetoclax 0 1
Adavosertib + Durvalumab Adavosertib Durvalumab 0 2
Aldoxorubicin + Durvalumab + Motolimod Aldoxorubicin Durvalumab Motolimod 0 1
Anastrozole + Durvalumab Anastrozole Durvalumab 0 1
Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab 0 1
Atezolizumab + Avelumab + Durvalumab + Nivolumab + Pembrolizumab + Plinabulin Atezolizumab Avelumab Durvalumab Nivolumab Pembrolizumab Plinabulin 0 1
AVB-S6-500 + Durvalumab AVB-S6-500 Durvalumab 0 1
Azacitidine + Durvalumab Azacitidine Durvalumab 0 5
Azacitidine + Durvalumab + Romidepsin Azacitidine Durvalumab Romidepsin 0 1
Azacitidine + Durvalumab + Tremelimumab Azacitidine Durvalumab Tremelimumab 0 1
AZD0171 + Durvalumab + Gemcitabine + Nab-paclitaxel AZD0171 Durvalumab Gemcitabine Nab-paclitaxel 0 1
AZD2811 + Durvalumab AZD2811 Durvalumab 0 1
AZD4547 + Durvalumab AZD4547 Durvalumab 0 1
AZD4635 + Cabazitaxel + Durvalumab AZD4635 Cabazitaxel Durvalumab 0 1
AZD4635 + Durvalumab AZD4635 Durvalumab 0 3
AZD5069 + Durvalumab AZD5069 Durvalumab 0 2
AZD5153 + Durvalumab AZD5153 Durvalumab 0 0
AZD5153 + Durvalumab + Selumetinib AZD5153 Durvalumab Selumetinib 0 1
AZD5305 + Datopotamab Deruxtecan + Durvalumab AZD5305 Datopotamab Deruxtecan Durvalumab 0 1
AZD8701 + Durvalumab AZD8701 Durvalumab 0 1
AZD9150 + Carboplatin + Durvalumab AZD9150 Carboplatin Durvalumab 0 0
AZD9150 + Carboplatin + Durvalumab + Gemcitabine AZD9150 Carboplatin Durvalumab Gemcitabine 0 1
AZD9150 + Carboplatin + Durvalumab + Nab-paclitaxel AZD9150 Carboplatin Durvalumab Nab-paclitaxel 0 1
AZD9150 + Cisplatin + Durvalumab AZD9150 Cisplatin Durvalumab 0 0
AZD9150 + Cisplatin + Durvalumab + Fluorouracil AZD9150 Cisplatin Durvalumab Fluorouracil 0 1
AZD9150 + Cisplatin + Durvalumab + Gemcitabine AZD9150 Cisplatin Durvalumab Gemcitabine 0 1
AZD9150 + Durvalumab AZD9150 Durvalumab 0 8
AZD9150 + Durvalumab + Gemcitabine AZD9150 Durvalumab Gemcitabine 0 0
AZD9150 + Durvalumab + Nab-paclitaxel AZD9150 Durvalumab Nab-paclitaxel 0 0
AZD9150 + Durvalumab + Paclitaxel AZD9150 Durvalumab Paclitaxel 0 0
AZD9150 + Durvalumab + Pemetrexed Disodium AZD9150 Durvalumab Pemetrexed Disodium 0 0
BCG solution + Durvalumab BCG solution Durvalumab 0 2
Belinostat + Durvalumab + Tremelimumab Belinostat Durvalumab Tremelimumab 0 1
Bendamustine + Durvalumab + Rituximab Bendamustine Durvalumab Rituximab 0 1
Bevacizumab + Capecitabine + CV301 + Durvalumab Bevacizumab CV301 Capecitabine Durvalumab 0 1
Bevacizumab + Carboplatin + Durvalumab + Paclitaxel Bevacizumab Carboplatin Durvalumab Paclitaxel 0 1
Bevacizumab + Doxorubicin + Durvalumab Bevacizumab Doxorubicin Durvalumab 0 1
Bevacizumab + Durvalumab Bevacizumab Durvalumab 0 4
Bevacizumab + Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin + Tremelimumab Bevacizumab Durvalumab Fluorouracil Leucovorin Oxaliplatin Tremelimumab 0 1
Bevacizumab + Durvalumab + Olaparib Bevacizumab Durvalumab Olaparib 0 2
Bevacizumab + Durvalumab + Tremelimumab Bevacizumab Durvalumab Tremelimumab 0 0
BI 1361849 + Durvalumab + Tremelimumab BI 1361849 Durvalumab Tremelimumab 0 1
Cabozantinib + Durvalumab Cabozantinib Durvalumab 0 2
Canakinumab + Durvalumab Canakinumab Durvalumab 0 1
Capecitabine + Cisplatin + Durvalumab Capecitabine Cisplatin Durvalumab 0 1
Capecitabine + CV301 + Durvalumab CV301 Capecitabine Durvalumab 0 1
Capecitabine + Durvalumab Capecitabine Durvalumab 0 2
Capecitabine + Durvalumab + Trastuzumab deruxtecan Capecitabine Durvalumab Trastuzumab deruxtecan 0 1
Capecitabine + Durvalumab + Tremelimumab Capecitabine Durvalumab Tremelimumab 0 1
Capivasertib + Durvalumab + Olaparib Capivasertib Durvalumab Olaparib 0 0
Capivasertib + Durvalumab + Paclitaxel Capivasertib Durvalumab Paclitaxel 0 1
Carboplatin + Ceralasertib + Durvalumab + Etoposide Carboplatin Ceralasertib Durvalumab Etoposide 0 1
Carboplatin + Cisplatin + Durvalumab + Etoposide Carboplatin Cisplatin Durvalumab Etoposide 0 3
Carboplatin + Cisplatin + Durvalumab + Etoposide + Tremelimumab Carboplatin Cisplatin Durvalumab Etoposide Tremelimumab 0 2
Carboplatin + Cisplatin + Durvalumab + Paclitaxel Carboplatin Cisplatin Durvalumab Paclitaxel 0 1
Carboplatin + Cisplatin + Durvalumab + Pemetrexed Disodium Carboplatin Cisplatin Durvalumab Pemetrexed Disodium 0 1
Carboplatin + Durvalumab Carboplatin Durvalumab 0 2
Carboplatin + Durvalumab + Etoposide Carboplatin Durvalumab Etoposide 0 7
Carboplatin + Durvalumab + Etoposide + Olaparib Carboplatin Durvalumab Etoposide Olaparib 0 1
Carboplatin + Durvalumab + Etoposide + Tremelimumab Carboplatin Durvalumab Etoposide Tremelimumab 0 2
Carboplatin + Durvalumab + Gemcitabine Carboplatin Durvalumab Gemcitabine 0 4
Carboplatin + Durvalumab + Gemcitabine + Tremelimumab Carboplatin Durvalumab Gemcitabine Tremelimumab 0 2
Carboplatin + Durvalumab + Nab-paclitaxel Carboplatin Durvalumab Nab-paclitaxel 0 4
Carboplatin + Durvalumab + Nab-paclitaxel + Tremelimumab Carboplatin Durvalumab Nab-paclitaxel Tremelimumab 0 1
Carboplatin + Durvalumab + Olaparib + Paclitaxel Carboplatin Durvalumab Olaparib Paclitaxel 0 1
Carboplatin + Durvalumab + Oleclumab Carboplatin Durvalumab Oleclumab 0 0
Carboplatin + Durvalumab + Oleclumab + Paclitaxel Carboplatin Durvalumab Oleclumab Paclitaxel 0 1
Carboplatin + Durvalumab + Paclitaxel Carboplatin Durvalumab Paclitaxel 0 16
Carboplatin + Durvalumab + Paclitaxel + Papaverine Carboplatin Durvalumab Paclitaxel Papaverine 0 1
Carboplatin + Durvalumab + Paclitaxel + Tremelimumab Carboplatin Durvalumab Paclitaxel Tremelimumab 0 1
Carboplatin + Durvalumab + Pemetrexed Disodium Carboplatin Durvalumab Pemetrexed Disodium 0 10
Carboplatin + Durvalumab + Trastuzumab deruxtecan Carboplatin Durvalumab Trastuzumab deruxtecan 0 1
Carboplatin + Durvalumab + Vinorelbine Carboplatin Durvalumab Vinorelbine 0 1
Cediranib + Durvalumab Cediranib Durvalumab 0 4
Cediranib + Durvalumab + Olaparib Cediranib Durvalumab Olaparib 0 1
Ceralasertib + Cisplatin + Durvalumab + Etoposide Ceralasertib Cisplatin Durvalumab Etoposide 0 1
Ceralasertib + Durvalumab Ceralasertib Durvalumab 1 4
Cetuximab + Durvalumab Cetuximab Durvalumab 0 1
CFI-400945 + Durvalumab CFI-400945 Durvalumab 0 1
Cisplatin + Docetaxel + Durvalumab Cisplatin Docetaxel Durvalumab 0 1
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Pegfilgrastim + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Pegfilgrastim Vinblastine 0 1
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Tremelimumab + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Tremelimumab Vinblastine 0 1
Cisplatin + Doxorubicin + Durvalumab + Methotrexate + Vinblastine Cisplatin Doxorubicin Durvalumab Methotrexate Vinblastine 0 3
Cisplatin + Durvalumab Cisplatin Durvalumab 0 4
Cisplatin + Durvalumab + Etoposide Cisplatin Durvalumab Etoposide 0 9
Cisplatin + Durvalumab + Fluorouracil Cisplatin Durvalumab Fluorouracil 0 1
Cisplatin + Durvalumab + Fluorouracil + Tremelimumab Cisplatin Durvalumab Fluorouracil Tremelimumab 0 1
Cisplatin + Durvalumab + Gemcitabine Cisplatin Durvalumab Gemcitabine 0 6
Cisplatin + Durvalumab + Gemcitabine + Tremelimumab Cisplatin Durvalumab Gemcitabine Tremelimumab 0 2
Cisplatin + Durvalumab + Oleclumab Cisplatin Durvalumab Oleclumab 0 0
Cisplatin + Durvalumab + Paclitaxel Cisplatin Durvalumab Paclitaxel 0 1
Cisplatin + Durvalumab + Pemetrexed Disodium Cisplatin Durvalumab Pemetrexed Disodium 0 11
Cisplatin + Durvalumab + Pemetrexed Disodium + TRC102 Cisplatin Durvalumab Pemetrexed Disodium TRC102 0 1
Cisplatin + Durvalumab + Trastuzumab deruxtecan Cisplatin Durvalumab Trastuzumab deruxtecan 0 1
Cisplatin + Durvalumab + Vinorelbine Cisplatin Durvalumab Vinorelbine 0 0
Copanlisib + Durvalumab Copanlisib Durvalumab 0 1
Copanlisib + Durvalumab + Olaparib Copanlisib Durvalumab Olaparib 0 1
Cyclophosphamide + Doxorubicin + Durvalumab + Lenalidomide + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Durvalumab Lenalidomide Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Doxorubicin + Durvalumab + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Durvalumab Prednisone Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Durvalumab + Epirubicin + Paclitaxel Cyclophosphamide Durvalumab Epirubicin Paclitaxel 0 1
Cyclophosphamide + Durvalumab + JCAR014 Cyclophosphamide Durvalumab JCAR014 0 1
Cyclophosphamide + Durvalumab + Tremelimumab Cyclophosphamide Durvalumab Tremelimumab 0 1
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Daratumumab + Dexamethasone + Durvalumab + Pomalidomide Daratumumab Dexamethasone Durvalumab Pomalidomide 0 1
Daratumumab + Durvalumab Daratumumab Durvalumab 0 2
Datopotamab Deruxtecan + Durvalumab Datopotamab Deruxtecan Durvalumab 0 2
DC AML Vaccine + Durvalumab DC AML Vaccine Durvalumab 0 1
Docetaxel + Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin Docetaxel Durvalumab Fluorouracil Leucovorin Oxaliplatin 0 1
Durvalumab Durvalumab 2 173
Durvalumab + E7046 Durvalumab E7046 0 1
Durvalumab + Enfortumab vedotin-ejfv Durvalumab Enfortumab vedotin-ejfv 0 0
Durvalumab + Enfortumab vedotin-ejfv + Tremelimumab Durvalumab Enfortumab vedotin-ejfv Tremelimumab 0 1
Durvalumab + Ensartinib Durvalumab Ensartinib 0 1
Durvalumab + Epacadostat Durvalumab Epacadostat 0 2
Durvalumab + Eribulin Durvalumab Eribulin 0 1
Durvalumab + Exemestane Durvalumab Exemestane 0 1
Durvalumab + FANG vaccine Durvalumab FANG vaccine 0 1
Durvalumab + Fluorouracil + Irinotecan + Leucovorin Durvalumab Fluorouracil Irinotecan Leucovorin 0 1
Durvalumab + Fluorouracil + Irinotecan + Leucovorin + Tremelimumab Durvalumab Fluorouracil Irinotecan Leucovorin Tremelimumab 0 1
Durvalumab + Fluorouracil + Leucovorin + Monalizumab + Oxaliplatin Durvalumab Fluorouracil Leucovorin Monalizumab Oxaliplatin 0 1
Durvalumab + Fluorouracil + Leucovorin + Oleclumab + Oxaliplatin Durvalumab Fluorouracil Leucovorin Oleclumab Oxaliplatin 0 2
Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin Durvalumab Fluorouracil Leucovorin Oxaliplatin 0 3
Durvalumab + Fluorouracil + Leucovorin + Oxaliplatin + Tremelimumab Durvalumab Fluorouracil Leucovorin Oxaliplatin Tremelimumab 0 1
Durvalumab + Fluorouracil + Mitomycin C Durvalumab Fluorouracil Mitomycin C 0 2
Durvalumab + Fluorouracil + Trastuzumab deruxtecan Durvalumab Fluorouracil Trastuzumab deruxtecan 0 1
Durvalumab + Fulvestrant + Olaparib Durvalumab Fulvestrant Olaparib 0 1
Durvalumab + Galunisertib Durvalumab Galunisertib 0 1
Durvalumab + Gefitinib Durvalumab Gefitinib 0 1
Durvalumab + Gemcitabine Durvalumab Gemcitabine 0 3
Durvalumab + Gemcitabine + Nab-paclitaxel Durvalumab Gemcitabine Nab-paclitaxel 0 1
Durvalumab + Gemcitabine + Nab-paclitaxel + Oleclumab Durvalumab Gemcitabine Nab-paclitaxel Oleclumab 0 2
Durvalumab + Gemcitabine + Nab-paclitaxel + Tremelimumab Durvalumab Gemcitabine Nab-paclitaxel Tremelimumab 0 1
Durvalumab + Gemcitabine + Oleclumab Durvalumab Gemcitabine Oleclumab 0 0
Durvalumab + Gemcitabine + Tremelimumab Durvalumab Gemcitabine Tremelimumab 0 1
Durvalumab + Gemcitabine + Vinorelbine Durvalumab Gemcitabine Vinorelbine 0 1
Durvalumab + Guadecitabine Durvalumab Guadecitabine 0 2
Durvalumab + Guadecitabine + Tremelimumab Durvalumab Guadecitabine Tremelimumab 0 1
Durvalumab + Ibrutinib Durvalumab Ibrutinib 0 3
Durvalumab + IPH5201 Durvalumab IPH5201 0 1
Durvalumab + IPH5201 + Oleclumab Durvalumab IPH5201 Oleclumab 0 1
Durvalumab + IPH5401 Durvalumab IPH5401 0 1
Durvalumab + Lenalidomide Durvalumab Lenalidomide 0 3
Durvalumab + Lenalidomide + PVX-410 Durvalumab Lenalidomide PVX-410 0 1
Durvalumab + Lenalidomide + Rituximab Durvalumab Lenalidomide Rituximab 0 1
Durvalumab + Lenvatinib + Tremelimumab Durvalumab Lenvatinib Tremelimumab 0 1
Durvalumab + Letrozole Durvalumab Letrozole 0 1
Durvalumab + Lisocabtagene maraleucel Durvalumab Lisocabtagene maraleucel 0 1
Durvalumab + LN-145 Durvalumab LN-145 0 1
Durvalumab + Loncastuximab tesirine-lpyl Durvalumab Loncastuximab tesirine-lpyl 0 1
Durvalumab + LY2510924 Durvalumab LY2510924 0 1
Durvalumab + LY3022855 Durvalumab LY3022855 0 1
Durvalumab + MEDI0457 Durvalumab MEDI0457 0 3
Durvalumab + MEDI0680 Durvalumab MEDI0680 0 1
Durvalumab + MEDI1191 Durvalumab MEDI1191 0 1
Durvalumab + MEDI5083 Durvalumab MEDI5083 0 1
Durvalumab + MEDI5395 Durvalumab MEDI5395 0 1
Durvalumab + MEDI9090 Durvalumab MEDI9090 0 1
Durvalumab + MEDI9197 Durvalumab MEDI9197 0 1
Durvalumab + MEDI9253 Durvalumab MEDI9253 0 1
Durvalumab + Metformin Durvalumab Metformin 0 1
Durvalumab + Mocetinostat Durvalumab Mocetinostat 0 2
Durvalumab + Mogamulizumab Durvalumab Mogamulizumab 0 0
Durvalumab + Monalizumab Durvalumab Monalizumab 0 6
Durvalumab + mRNA-2752 Durvalumab mRNA-2752 0 1
Durvalumab + Nab-paclitaxel Durvalumab Nab-paclitaxel 0 2
Durvalumab + Nab-paclitaxel + Oleclumab Durvalumab Nab-paclitaxel Oleclumab 0 0
Durvalumab + Nab-paclitaxel + Poly ICLC + Tremelimumab + TSMA-based SLP vaccine Durvalumab Nab-paclitaxel Poly ICLC TSMA-based SLP vaccine Tremelimumab 0 1
Durvalumab + Nab-paclitaxel + Tremelimumab Durvalumab Nab-paclitaxel Tremelimumab 0 1
Durvalumab + Olaparib Durvalumab Olaparib 1 21
Durvalumab + Olaparib + Tremelimumab Durvalumab Olaparib Tremelimumab 0 2
Durvalumab + Oleclumab Durvalumab Oleclumab 0 11
Durvalumab + Oleclumab + Paclitaxel Durvalumab Oleclumab Paclitaxel 0 1
Durvalumab + Oleclumab + Pemetrexed Disodium Durvalumab Oleclumab Pemetrexed Disodium 0 0
Durvalumab + ONCOS-102 Durvalumab ONCOS-102 0 1
Durvalumab + Oportuzumab monatox Durvalumab Oportuzumab monatox 0 1
Durvalumab + Osimertinib Durvalumab Osimertinib 0 1
Durvalumab + Paclitaxel Durvalumab Paclitaxel 0 2
Durvalumab + Paclitaxel + Selumetinib Durvalumab Paclitaxel Selumetinib 0 0
Durvalumab + Paclitaxel + Trastuzumab deruxtecan Durvalumab Paclitaxel Trastuzumab deruxtecan 0 2
Durvalumab + Pegylated liposomal-doxorubicin Durvalumab Pegylated liposomal-doxorubicin 0 1
Durvalumab + Pemetrexed Disodium Durvalumab Pemetrexed Disodium 0 3
Durvalumab + Pemetrexed Disodium + Trastuzumab deruxtecan Durvalumab Pemetrexed Disodium Trastuzumab deruxtecan 0 1
Durvalumab + Personalized cancer vaccine + Tremelimumab Durvalumab Personalized cancer vaccine Tremelimumab 0 1
Durvalumab + Pertuzumab + Trastuzumab Durvalumab Pertuzumab Trastuzumab 0 1
Durvalumab + Poly ICLC Durvalumab Poly ICLC 0 2
Durvalumab + Poly ICLC + PVX-410 Durvalumab PVX-410 Poly ICLC 0 1
Durvalumab + Pralatrexate + Romidepsin Durvalumab Pralatrexate Romidepsin 0 1
Durvalumab + Prednisone Durvalumab Prednisone 0 1
Durvalumab + PVX-410 Durvalumab PVX-410 0 1
Durvalumab + Ramucirumab Durvalumab Ramucirumab 0 1
Durvalumab + Regorafenib Durvalumab Regorafenib 0 3
Durvalumab + Romidepsin Durvalumab Romidepsin 0 1
Durvalumab + S-588210 Durvalumab S-588210 0 1
Durvalumab + Savolitinib Durvalumab Savolitinib 0 1
Durvalumab + Selumetinib Durvalumab Selumetinib 0 4
Durvalumab + Selumetinib + Tremelimumab Durvalumab Selumetinib Tremelimumab 0 1
Durvalumab + Sirolimus Durvalumab Sirolimus 0 1
Durvalumab + SNDX-6352 Durvalumab SNDX-6352 0 2
Durvalumab + Tavolimab Durvalumab Tavolimab 0 1
Durvalumab + Tazemetostat Durvalumab Tazemetostat 0 1
Durvalumab + TEW 7197 Durvalumab TEW 7197 0 1
Durvalumab + Tivozanib Durvalumab Tivozanib 0 1
Durvalumab + Topotecan Durvalumab Topotecan 0 1
Durvalumab + TPIV 200 Durvalumab TPIV 200 0 1
Durvalumab + Trabectedin Durvalumab Trabectedin 0 1
Durvalumab + Trametinib Durvalumab Trametinib 0 2
Durvalumab + Trastuzumab Durvalumab Trastuzumab 0 1
Durvalumab + Trastuzumab deruxtecan Durvalumab Trastuzumab deruxtecan 0 5
Durvalumab + Tremelimumab Durvalumab Tremelimumab 0 90
Durvalumab + Tremelimumab + Vinorelbine Durvalumab Tremelimumab Vinorelbine 0 1
Durvalumab + Tremelimumab + Yttrium-90 microsphere therapy Durvalumab Tremelimumab Yttrium-90 microsphere therapy 0 1
Durvalumab + VCN-01 Durvalumab VCN-01 0 1
Durvalumab + Vistusertib Durvalumab Vistusertib 0 2


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