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Drug Name Datopotamab deruxtecan
Trade Name
Synonyms Dato-DXd|DS1062a|DS 1062a|DS-1062a
Drug Descriptions

Datopotamab deruxtecan (DS-1062a) is an antibody-drug conjugate (ADC) comprising an antibody that targets TROP2 linked to the topoisomerase I inhibitor DXd, which may induce apoptosis and inhibit tumor growth (PMID: 34413126).

DrugClasses TROP2 Antibody 8
CAS Registry Number NA
NCIT ID C151967

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD2936 + Carboplatin + Datopotamab deruxtecan AZD2936 Carboplatin Datopotamab deruxtecan 0 1
AZD2936 + Datopotamab deruxtecan AZD2936 Datopotamab deruxtecan 0 2
AZD5305 + Carboplatin + Datopotamab deruxtecan AZD5305 Carboplatin Datopotamab deruxtecan 0 0
AZD5305 + Datopotamab deruxtecan AZD5305 Datopotamab deruxtecan 0 1
AZD5305 + Datopotamab deruxtecan + Durvalumab AZD5305 Datopotamab deruxtecan Durvalumab 0 1
Bevacizumab + Capecitabine + Datopotamab deruxtecan Bevacizumab Capecitabine Datopotamab deruxtecan 0 1
Bevacizumab + Datopotamab deruxtecan + Fluorouracil + Leucovorin Bevacizumab Datopotamab deruxtecan Fluorouracil Leucovorin 0 1
Capecitabine + Datopotamab deruxtecan Capecitabine Datopotamab deruxtecan 0 1
Capecitabine + Datopotamab deruxtecan + Nivolumab Capecitabine Datopotamab deruxtecan Nivolumab 0 1
Carboplatin + Datopotamab deruxtecan Carboplatin Datopotamab deruxtecan 0 1
Carboplatin + Datopotamab deruxtecan + Durvalumab Carboplatin Datopotamab deruxtecan Durvalumab 0 2
Carboplatin + Datopotamab deruxtecan + MEDI5752 Carboplatin Datopotamab deruxtecan MEDI5752 0 1
Carboplatin + Datopotamab deruxtecan + Pembrolizumab Carboplatin Datopotamab deruxtecan Pembrolizumab 0 2
Cisplatin + Datopotamab deruxtecan + Pembrolizumab Cisplatin Datopotamab deruxtecan Pembrolizumab 0 2
Datopotamab deruxtecan Datopotamab deruxtecan 0 12
Datopotamab deruxtecan + DS-3201b DS-3201b Datopotamab deruxtecan 0 1
Datopotamab deruxtecan + Durvalumab Datopotamab deruxtecan Durvalumab 0 5
Datopotamab deruxtecan + Fluorouracil Datopotamab deruxtecan Fluorouracil 0 1
Datopotamab deruxtecan + Fluorouracil + Nivolumab Datopotamab deruxtecan Fluorouracil Nivolumab 0 1
Datopotamab deruxtecan + MEDI5752 Datopotamab deruxtecan MEDI5752 0 1
Datopotamab deruxtecan + Osimertinib Datopotamab deruxtecan Osimertinib 0 1
Datopotamab deruxtecan + Pembrolizumab Datopotamab deruxtecan Pembrolizumab 0 3


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