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|Therapy Name||AZD5305 + Datopotamab Deruxtecan + Durvalumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZD5305||AZD 5305|AZD-5305||PARP-1 Inhibitor 6||AZD5035 inhibits PARP1, potentially inhibiting cell growth and inducing tumor regression (PMID: 35929986).|
|Datopotamab Deruxtecan||Dato-DXd|DS1062a|DS 1062a|DS-1062a||Datopotamab Deruxtecan (DS-1062a) is an antibody-drug conjugate comprising an antibody that targets TROP2 linked to the topoisomerase I inhibitor DXd, which may induce apoptosis and inhibit tumor growth (PMID: 34413126).|
|Durvalumab||Imfinzi||MEDI4736||Immune Checkpoint Inhibitor 151 PD-L1/PD-1 antibody 98||Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, in combination with Imjudo (tremelimumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer, and in combination with Imjudo (tremelimumab) in adult patients with unresectable hepatocellular carcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05489211||Phase II||Capecitabine + Datopotamab Deruxtecan AZD5305 + Datopotamab Deruxtecan + Durvalumab Capecitabine + Datopotamab Deruxtecan + Nivolumab Carboplatin + Datopotamab Deruxtecan Datopotamab Deruxtecan + Fluorouracil AZD5305 + Datopotamab Deruxtecan Datopotamab Deruxtecan + Durvalumab Datopotamab Deruxtecan + Fluorouracil + Nivolumab Bevacizumab + Datopotamab Deruxtecan + Fluorouracil + Leucovorin Bevacizumab + Capecitabine + Datopotamab Deruxtecan Datopotamab Deruxtecan||Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours||Recruiting||USA | ITA | FRA | ESP | DEU | CAN||8|