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|Therapy Name||DS-1062a + Durvalumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|DS-1062a||DS-1062a is an antibody-drug conjugate comprising an antibody that targets TROP2 linked to the topoisomerase I inhibitor DXd, which may inhibit tumor growth (J Clin Oncol 36, 2018 (suppl; abstr e24206)).|
|Durvalumab||Imfinzi||MEDI4736||Immune Checkpoint Inhibitor 135 PD-L1/PD-1 antibody 79||Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, and in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04612751||Phase I||DS-1062a + Durvalumab||DS-1062a in Combination With Durvalumab in Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-Lung04)||Recruiting||USA||2|