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Therapy Name Datopotamab Deruxtecan
Synonyms
Therapy Description

DS-1062a is an antibody-drug conjugate comprising an antibody that targets TROP2 linked to the topoisomerase I inhibitor DXd, which may inhibit tumor growth (J Clin Oncol 36, 2018 (suppl; abstr e24206)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Datopotamab Deruxtecan Dato-DXd|DS1062a|DS 1062a|DS-1062a Datopotamab Deruxtecan (DS-1062a) is an antibody-drug conjugate comprising an antibody that targets TROP2 linked to the topoisomerase I inhibitor DXd, which may induce apoptosis and inhibit tumor growth (PMID: 34413126).

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05104866 Phase III Gemcitabine Capecitabine Datopotamab Deruxtecan Vinorelbine Eribulin A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01) Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL 14
NCT04656652 Phase III Docetaxel Datopotamab Deruxtecan Study of DS-1062A Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-LUNG01) Recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL 18
NCT04484142 Phase II Datopotamab Deruxtecan Study of DS-1062a in Advanced or Metastatic Non-small Cell Lung Cancer With Actionable Genomic Alterations (TROPION-Lung05) Active, not recruiting USA | ITA | FRA | ESP | DEU 5
NCT03401385 Phase I Datopotamab Deruxtecan First-in-human Study of DS-1062a for Advanced Solid Tumors Recruiting USA 1
NCT05374512 Phase III Eribulin Nab-paclitaxel Paclitaxel Datopotamab Deruxtecan Carboplatin Capecitabine A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy Not yet recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL 10
NCT04940325 Phase II Datopotamab Deruxtecan Datopotamab (DS-1062a) in Advanced and/or Unresectable Non-Small Cell Lung Cancer (ICARUS-LUNG01) Recruiting FRA 0


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