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Drug Name Ramucirumab
Trade Name Cyramza
Synonyms LY3009806
Drug Descriptions

Cyramza (ramucirumab) is a monoclonal antibody, which binds and inhibits VEGFR2 (KDR) resulting in decreased angiogenesis (PMID: 24094768). Cyramza (ramucirumab) is FDA approved for use as a monotherapy or in combination with paclitaxel in patients with gastric or gastroesophageal junction adenocarcinoma who progressed on chemotherapy, in combination with erlotinib as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion mutations or L858R, in combination with decetaxel in patients with NSCLC who progressed on prior therapy, in combination with FOLFIRI in patients with colorectal cancer who progressed on prior therapy, and as monotherapy in patients with hepatocellular carcinoma who have received sorafenib (FDA.gov).

DrugClasses VEGFR2 Antibody 4

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Ramucirumab Abemaciclib Ramucirumab 1 1
Atezolizumab + Ramucirumab Atezolizumab Ramucirumab 0 1
Carboplatin + Paclitaxel + Ramucirumab Carboplatin Paclitaxel Ramucirumab 1 2
Cetuximab + Irinotecan + Ramucirumab Cetuximab Irinotecan Ramucirumab 0 1
Crenolanib + Paclitaxel + Ramucirumab Crenolanib Paclitaxel Ramucirumab 0 1
Cyclophosphamide + Ramucirumab + Vinorelbine Cyclophosphamide Ramucirumab Vinorelbine 0 1
Dacarbazine + Ramucirumab Dacarbazine Ramucirumab 0 0
Docetaxel + Gemcitabine + Ramucirumab Docetaxel Gemcitabine Ramucirumab 0 1
Docetaxel + Nivolumab + Ramucirumab Docetaxel Nivolumab Ramucirumab 0 1
Docetaxel + Pembrolizumab + Ramucirumab Docetaxel Pembrolizumab Ramucirumab 0 1
Docetaxel + Ramucirumab Docetaxel Ramucirumab 4 3
Durvalumab + Ramucirumab Durvalumab Ramucirumab 0 1
Emibetuzumab + Ramucirumab Emibetuzumab Ramucirumab 4 1
Erlotinib + Ramucirumab Erlotinib Ramucirumab 0 1
Fluorouracil + Irinotecan + Leucovorin + Ramucirumab Fluorouracil Irinotecan Leucovorin Ramucirumab 1 0
Fluorouracil + Leucovorin + Oxaliplatin + Ramucirumab Fluorouracil Leucovorin Oxaliplatin Ramucirumab 1 0
Gefitinib + Ramucirumab Gefitinib Ramucirumab 0 1
Irinotecan + Ramucirumab Irinotecan Ramucirumab 0 1
LY3127804 + Ramucirumab LY3127804 Ramucirumab 1 0
LY3300054 + Ramucirumab LY3300054 Ramucirumab 0 1
Merestinib + Ramucirumab Merestinib Ramucirumab 1 1
MM-398 + Ramucirumab MM-398 Ramucirumab 0 1
Nab-paclitaxel + Ramucirumab Nab-paclitaxel Ramucirumab 0 2
Nivolumab + Ramucirumab Nivolumab Ramucirumab 1 2
Nivolumab + Ramucirumab + Rucaparib Nivolumab Ramucirumab Rucaparib 0 1
Octreotide + Ramucirumab Octreotide Ramucirumab 0 1
Olaparib + Ramucirumab Olaparib Ramucirumab 0 1
Oraxol + Ramucirumab Oraxol Ramucirumab 0 1
Osimertinib + Ramucirumab Osimertinib Ramucirumab 0 3
Oxaliplatin + Ramucirumab + Tegafur-gimeracil-oteracil Potassium Oxaliplatin Ramucirumab Tegafur-gimeracil-oteracil Potassium 2 0
Paclitaxel + Ramucirumab Paclitaxel Ramucirumab 2 3
Paclitaxel + Ramucirumab + TRK-950 Paclitaxel Ramucirumab TRK-950 0 1
Paclitaxel + Ramucirumab + XOMA 052 Paclitaxel Ramucirumab XOMA 052 0 1
Pembrolizumab + Ramucirumab Pembrolizumab Ramucirumab 0 5
Ramucirumab Ramucirumab 10 13
Ramucirumab + Rucaparib Ramucirumab Rucaparib 0 1
Ramucirumab + Trastuzumab Ramucirumab Trastuzumab 0 1
Ramucirumab + Trifluridine-tipiracil hydrochloride Ramucirumab Trifluridine-tipiracil hydrochloride 0 1


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