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Drug Name PRS-343
Trade Name
Synonyms
Drug Descriptions

PRS-343 is a bispecific antibody targeting both CD137 (4-1BB) and Erbb2 (Her2), resulting in enhanced anti-tumor immune response against Erbb2 (Her2)-positive tumor cells (Eur J Cancer, Dec 2016, 69 (Suppl. 1): S99, abstract 301, PMID: 31138587).

DrugClasses HER2 (ERBB2) Antibody 73 TNFRSF9 Antibody 30
CAS Registry Number NA
NCIT ID C142890

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + PRS-343 Atezolizumab PRS-343 0 1
Paclitaxel + PRS-343 + Ramucirumab PRS-343 Paclitaxel Ramucirumab 0 1
PRS-343 PRS-343 0 1
PRS-343 + Tucatinib PRS-343 Tucatinib 0 1


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