Drug Detail

Drug Name Tucatinib
Trade Name
Synonyms ONT-380|ARRY-380|irbinitinib
Drug Descriptions

Tucatinib (ARRY-380) selectivity inhibits ERBB2 (HER2), resulting in decreased proliferation and increased apoptosis in ERBB2 (HER2) expressing tumor cells (PMID: 28053022).

DrugClasses HER2 Inhibitor 22

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Trastuzumab + Tucatinib Abemaciclib Trastuzumab Tucatinib 0 1
Ado-trastuzumab emtansine + Tucatinib Ado-trastuzumab emtansine Tucatinib 4 1
Capecitabine + Trastuzumab + Tucatinib Capecitabine Trastuzumab Tucatinib 1 3
Capecitabine + Tucatinib Capecitabine Tucatinib 1 1
Letrozole + Palbociclib + Tucatinib Letrozole Palbociclib Tucatinib 0 1
Trastuzumab + Tucatinib Trastuzumab Tucatinib 1 3
Tucatinib Tucatinib 8 0


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