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Drug Name Tucatinib
Trade Name Tukysa
Synonyms ONT-380|ARRY-380|irbinitinib
Drug Descriptions

Tukysa (tucatinib) selectivity inhibits ERBB2 (HER2), resulting in decreased proliferation and increased apoptosis in ERBB2 (HER2) expressing tumor cells (PMID: 28053022). Tukysa (tucatinib) in combination with Herceptin (trastuzumab) and Xeloda (capecitabine) is FDA approved for use in patients with advanced unresectable or metastatic ERBB2 (HER2)-positive breast cancer, including patients with brain metastasis, who have received prior anti-HER2 therapies (FDA.gov).

DrugClasses HER2 Inhibitor 29
CAS Registry Number 937263-43-9
NCIT ID C77896


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Trastuzumab + Tucatinib Abemaciclib Trastuzumab Tucatinib 0 1
Ado-trastuzumab emtansine + Tucatinib Ado-trastuzumab emtansine Tucatinib 0 4
Anastrozole + Pertuzumab + Trastuzumab + Tucatinib Anastrozole Pertuzumab Trastuzumab Tucatinib 0 1
Capecitabine + Trastuzumab + Tucatinib Capecitabine Trastuzumab Tucatinib 0 4
Capecitabine + Tucatinib Capecitabine Tucatinib 0 1
Fluorouracil + Leucovorin + Oxaliplatin + Trastuzumab + Tucatinib Fluorouracil Leucovorin Oxaliplatin Trastuzumab Tucatinib 0 1
Fulvestrant + Pertuzumab + Trastuzumab + Tucatinib Fulvestrant Pertuzumab Trastuzumab Tucatinib 0 1
Fulvestrant + Trastuzumab + Tucatinib Fulvestrant Trastuzumab Tucatinib 0 1
Gemcitabine + Trastuzumab + Tucatinib Gemcitabine Trastuzumab Tucatinib 0 0
Letrozole + Palbociclib + Tucatinib Letrozole Palbociclib Tucatinib 0 1
Letrozole + Pertuzumab + Trastuzumab + Tucatinib Letrozole Pertuzumab Trastuzumab Tucatinib 0 1
Paclitaxel + Ramucirumab + Trastuzumab + Tucatinib Paclitaxel Ramucirumab Trastuzumab Tucatinib 0 1
Paclitaxel + Ramucirumab + Tucatinib Paclitaxel Ramucirumab Tucatinib 0 1
Pembrolizumab + Trastuzumab + Tucatinib Pembrolizumab Trastuzumab Tucatinib 0 1
Trastuzumab + Tucatinib Trastuzumab Tucatinib 0 4
Trastuzumab + Tucatinib + Vinorelbine Trastuzumab Tucatinib Vinorelbine 0 1
Trastuzumab deruxtecan + Tucatinib Trastuzumab deruxtecan Tucatinib 0 1
Tucatinib Tucatinib 0 1

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