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Drug Name Trastuzumab deruxtecan
Trade Name Enhertu
Synonyms DS-8201|DS8201a|T-DXd|DS-8201a|fam-trastuzumab deruxtecan-nxki
Drug Descriptions

Enhertu (trastuzumab deruxtecan) is an antibody-drug conjugate comprising an anti-ERBB2 (HER2) antibody linked to a derivative of the topoisomerase inhibitor DX-8951, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in decreased growth of tumors, including tumors with low ERBB2 (HER2) expression (PMID: 27026201). Enhertu (fam-trastuzumab deruxtecan-nxki) is FDA approved for use in patients with ERBB2 (HER2)-positive breast cancer who have received two or more anti-HER2 therapies previously (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 38

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capecitabine + Cisplatin + Trastuzumab deruxtecan Capecitabine Cisplatin Trastuzumab deruxtecan 0 0
Capecitabine + Durvalumab + Trastuzumab deruxtecan Capecitabine Durvalumab Trastuzumab deruxtecan 0 1
Capecitabine + Oxaliplatin + Trastuzumab deruxtecan Capecitabine Oxaliplatin Trastuzumab deruxtecan 0 1
Capecitabine + Trastuzumab deruxtecan Capecitabine Trastuzumab deruxtecan 0 1
Cisplatin + Fluorouracil + Trastuzumab deruxtecan Cisplatin Fluorouracil Trastuzumab deruxtecan 0 0
Durvalumab + Fluorouracil + Trastuzumab deruxtecan Durvalumab Fluorouracil Trastuzumab deruxtecan 0 1
Durvalumab + Trastuzumab deruxtecan Durvalumab Trastuzumab deruxtecan 0 2
Fluorouracil + Oxaliplatin + Trastuzumab deruxtecan Fluorouracil Oxaliplatin Trastuzumab deruxtecan 0 1
Fluorouracil + Trastuzumab deruxtecan Fluorouracil Trastuzumab deruxtecan 0 1
Nivolumab + Trastuzumab deruxtecan Nivolumab Trastuzumab deruxtecan 0 1
Pembrolizumab + Trastuzumab deruxtecan Pembrolizumab Trastuzumab deruxtecan 0 1
Trastuzumab deruxtecan Trastuzumab deruxtecan 15 12


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