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Drug Name Trastuzumab deruxtecan
Trade Name Enhertu
Synonyms DS-8201|DS8201a|T-DXd|DS-8201|fam-trastuzumab deruxtecan-nxki|DS-8201a
Drug Descriptions

Enhertu (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC) comprising an anti-ERBB2 (HER2) antibody linked to a derivative of the topoisomerase inhibitor DX-8951, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in decreased growth of tumors, including tumors with low ERBB2 (HER2) expression (PMID: 27026201). Enhertu (fam-trastuzumab deruxtecan-nxki) is FDA approved for use in patients with ERBB2 (HER2)-positive breast cancer who have received two or more anti-HER2 therapies previously, in patients with ERBB2 (HER2)-low (IHC 1+ or IHC 2+/ISH -) breast cancer received prior chemotherapy, in patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma who have received prior trastuzumab-based therapy, and in patients with non-small cell lung cancer harboring ERBB2 (HER2) activating mutations who have received prior systemic therapy (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 73 HER2 (ERBB2) Antibody-Drug Conjugate 27
CAS Registry Number 1826843-81-5
NCIT ID C128799

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib + Trastuzumab deruxtecan Adavosertib Trastuzumab deruxtecan 0 0
Anastrozole + Trastuzumab deruxtecan Anastrozole Trastuzumab deruxtecan 0 2
Capecitabine + Cisplatin + Trastuzumab deruxtecan Capecitabine Cisplatin Trastuzumab deruxtecan 0 0
Capecitabine + Durvalumab + Trastuzumab deruxtecan Capecitabine Durvalumab Trastuzumab deruxtecan 0 1
Capecitabine + Fluorouracil + MEDI5752 + Trastuzumab deruxtecan Capecitabine Fluorouracil MEDI5752 Trastuzumab deruxtecan 0 1
Capecitabine + Fluorouracil + Pembrolizumab + Trastuzumab deruxtecan Capecitabine Fluorouracil Pembrolizumab Trastuzumab deruxtecan 0 1
Capecitabine + Oxaliplatin + Trastuzumab deruxtecan Capecitabine Oxaliplatin Trastuzumab deruxtecan 0 1
Capecitabine + Pembrolizumab + Trastuzumab deruxtecan Capecitabine Pembrolizumab Trastuzumab deruxtecan 0 0
Capecitabine + SBT6050 + Trastuzumab deruxtecan + Tucatinib Capecitabine SBT6050 Trastuzumab deruxtecan Tucatinib 0 0
Capecitabine + Trastuzumab deruxtecan Capecitabine Trastuzumab deruxtecan 0 3
Capecitabine + Trastuzumab deruxtecan + Tucatinib Capecitabine Trastuzumab deruxtecan Tucatinib 0 0
Capivasertib + Trastuzumab deruxtecan Capivasertib Trastuzumab deruxtecan 0 1
Carboplatin + Durvalumab + Trastuzumab deruxtecan Carboplatin Durvalumab Trastuzumab deruxtecan 0 1
Carboplatin + MEDI5752 + Trastuzumab deruxtecan Carboplatin MEDI5752 Trastuzumab deruxtecan 0 1
Ceralasertib + Trastuzumab deruxtecan Ceralasertib Trastuzumab deruxtecan 0 1
Cisplatin + Durvalumab + Trastuzumab deruxtecan Cisplatin Durvalumab Trastuzumab deruxtecan 0 1
Cisplatin + Fluorouracil + Trastuzumab deruxtecan Cisplatin Fluorouracil Trastuzumab deruxtecan 0 0
DS-1103a + Trastuzumab deruxtecan DS-1103a Trastuzumab deruxtecan 0 1
DS-3201b + Trastuzumab deruxtecan DS-3201b Trastuzumab deruxtecan 0 2
Durvalumab + Fluorouracil + Trastuzumab deruxtecan Durvalumab Fluorouracil Trastuzumab deruxtecan 0 1
Durvalumab + Paclitaxel + Trastuzumab deruxtecan Durvalumab Paclitaxel Trastuzumab deruxtecan 0 2
Durvalumab + Pemetrexed Disodium + Trastuzumab deruxtecan Durvalumab Pemetrexed Disodium Trastuzumab deruxtecan 0 1
Durvalumab + Trastuzumab deruxtecan Durvalumab Trastuzumab deruxtecan 0 5
ELVN-002 + Trastuzumab deruxtecan ELVN-002 Trastuzumab deruxtecan 0 1
Evorpacept + Trastuzumab deruxtecan Evorpacept Trastuzumab deruxtecan 0 1
Fluorouracil + Oxaliplatin + Trastuzumab deruxtecan Fluorouracil Oxaliplatin Trastuzumab deruxtecan 0 1
Fluorouracil + Pembrolizumab + Trastuzumab deruxtecan Fluorouracil Pembrolizumab Trastuzumab deruxtecan 0 1
Fluorouracil + Trastuzumab deruxtecan Fluorouracil Trastuzumab deruxtecan 0 2
Fulvestrant + Trastuzumab deruxtecan Fulvestrant Trastuzumab deruxtecan 0 1
MEDI5752 + Trastuzumab deruxtecan MEDI5752 Trastuzumab deruxtecan 0 1
Neratinib + Trastuzumab deruxtecan Neratinib Trastuzumab deruxtecan 0 1
Nivolumab + Trastuzumab deruxtecan Nivolumab Trastuzumab deruxtecan 0 2
Olaparib + Trastuzumab deruxtecan Olaparib Trastuzumab deruxtecan 0 1
Paclitaxel + Pertuzumab + Trastuzumab + Trastuzumab deruxtecan Paclitaxel Pertuzumab Trastuzumab Trastuzumab deruxtecan 0 1
Paclitaxel + Trastuzumab deruxtecan Paclitaxel Trastuzumab deruxtecan 0 1
Pembrolizumab + Trastuzumab deruxtecan Pembrolizumab Trastuzumab deruxtecan 0 2
Pertuzumab + Trastuzumab deruxtecan Pertuzumab Trastuzumab deruxtecan 0 2
SBT6050 + Trastuzumab deruxtecan SBT6050 Trastuzumab deruxtecan 0 1
Selpercatinib + Trastuzumab deruxtecan Selpercatinib Trastuzumab deruxtecan 0 0
Trastuzumab + Trastuzumab deruxtecan Trastuzumab Trastuzumab deruxtecan 0 0
Trastuzumab deruxtecan Trastuzumab deruxtecan 0 35
Trastuzumab deruxtecan + Tucatinib Trastuzumab deruxtecan Tucatinib 0 1
Trastuzumab deruxtecan + ZN-A-1041 Trastuzumab deruxtecan ZN-A-1041 0 1


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