Drug Detail
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| Drug Name | Trastuzumab deruxtecan |
| Trade Name | Enhertu |
| Synonyms | DS-8201|DS8201a|T-DXd|DS-8201fam-trastuzumab deruxtecan-nxki |
| Drug Descriptions |
Enhertu (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC) comprising an anti-ERBB2 (HER2) antibody linked to a derivative of the topoisomerase inhibitor DX-8951, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in decreased growth of tumors, including tumors with low ERBB2 (HER2) expression (PMID: 27026201). Enhertu (fam-trastuzumab deruxtecan-nxki) is FDA approved for use in patients with ERBB2 (HER2)-positive breast cancer who have received two or more anti-HER2 therapies previously, in patients with ERBB2 (HER2)-low (IHC 1+ or IHC 2+/ISH -) breast cancer received prior chemotherapy, in patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma who have received prior trastuzumab-based therapy, and in patients with non-small cell lung cancer harboring ERBB2 (HER2) activating mutations who have received prior systemic therapy (FDA.gov). |
| DrugClasses | HER2 (ERBB2) Antibody 58 HER2 (ERBB2) Antibody-Drug Conjugate 18 |
| CAS Registry Number | 1826843-81-5 |
| NCIT ID | C128799 |
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