Drug Detail


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Drug Name SBT6050
Trade Name
Synonyms SBT-6050|SBT 6050|ImmunoTAC SBT6050|HER2-directed TLR8 Agonist SBT6050
Drug Descriptions

SBT6050 comprises a TLR8 (CD288) agonist linked to an Erbb2 (Her2) monoclonal antibody, which may lead to activation of TLR8 expressing myeloid cells in the context of Erbb2 (Her2)-expressing tumors, potentially resulting in increased anti-tumor immune response (Cancer Res 2020;80(16 Suppl):Abstract nr 4537).

DrugClasses HER2 (ERBB2) Antibody 64 TLR8 Agonist 7
CAS Registry Number NA
NCIT ID C174010


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capecitabine + SBT6050 + Trastuzumab + Tucatinib Capecitabine SBT6050 Trastuzumab Tucatinib 0 1
Capecitabine + SBT6050 + Trastuzumab deruxtecan + Tucatinib Capecitabine SBT6050 Trastuzumab deruxtecan Tucatinib 0 0
Cemiplimab + SBT6050 Cemiplimab SBT6050 0 1
Pembrolizumab + SBT6050 Pembrolizumab SBT6050 0 1
SBT6050 SBT6050 0 1
SBT6050 + Trastuzumab + Tucatinib SBT6050 Trastuzumab Tucatinib 0 1
SBT6050 + Trastuzumab deruxtecan SBT6050 Trastuzumab deruxtecan 0 1

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