Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Cemiplimab
Trade Name Libtayo
Synonyms REGN2810|SAR439684
Drug Descriptions

Libtayo (cemiplimab) is a human antibody that targets PD-1 (PDCD1) and prevents interaction with PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in increased anti-tumor immune response and decreased tumor growth (PMID: 28265006). Libtayo (cemiplimab) is FDA approved for use in patients with cutaneous squamous cell carcinoma, who are not not eligible for curative surgery or radiation, in patients with locally advanced or metastatic basal cell carcinoma who have received or are not eligible for a hedgehog pathway inhibitor, and as first-line treatment in patients with advanced n0n-small cell lung cancer with high PD-L1 expression (TPS>=50%) and no EGFR, ALK, or ROS1 aberrations (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 98 PD-L1/PD-1 antibody 68
CAS Registry Number 1801342-60-8
NCIT ID C121540

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
ASP-1929 + Cemiplimab ASP-1929 Cemiplimab 0 1
BKT140 + Cemiplimab + Gemcitabine + Nab-paclitaxel BKT140 Cemiplimab Gemcitabine Nab-paclitaxel 0 1
BNT112 + Cemiplimab BNT112 Cemiplimab 0 1
Carboplatin + Cemiplimab + Cetuximab + Docetaxel Carboplatin Cemiplimab Cetuximab Docetaxel 0 1
Carboplatin + Cemiplimab + Cyclophosphamide + Doxorubicin + Paclitaxel Carboplatin Cemiplimab Cyclophosphamide Doxorubicin Paclitaxel 0 1
Carboplatin + Cemiplimab + Docetaxel Carboplatin Cemiplimab Docetaxel 0 1
Carboplatin + Cemiplimab + Paclitaxel Carboplatin Cemiplimab Paclitaxel 0 1
Carboplatin + Cemiplimab + Pemetrexed Disodium Carboplatin Cemiplimab Pemetrexed Disodium 0 1
Cemiplimab Cemiplimab 2 20
Cemiplimab + Cetuximab + Cisplatin + Docetaxel Cemiplimab Cetuximab Cisplatin Docetaxel 0 1
Cemiplimab + Cyclophosphamide Cemiplimab Cyclophosphamide 0 1
Cemiplimab + Cyclophosphamide + Doxorubicin + Paclitaxel Cemiplimab Cyclophosphamide Doxorubicin Paclitaxel 0 1
Cemiplimab + Cyclophosphamide + Sargramostim Cemiplimab Cyclophosphamide Sargramostim 0 1
Cemiplimab + Dabrafenib + Trametinib Cemiplimab Dabrafenib Trametinib 0 1
Cemiplimab + Degarelix + Docetaxel + Leuprolide Cemiplimab Degarelix Docetaxel Leuprolide 0 1
Cemiplimab + Degarelix + Leuprolide Cemiplimab Degarelix Leuprolide 0 0
Cemiplimab + Docetaxel Cemiplimab Docetaxel 0 1
Cemiplimab + Everolimus + Prednisone Cemiplimab Everolimus Prednisone 0 1
Cemiplimab + INO-5401 + INO-9012 + Temozolomide Cemiplimab INO-5401 INO-9012 Temozolomide 0 1
Cemiplimab + Ipilimumab Cemiplimab Ipilimumab 0 4
Cemiplimab + ISA101b Cemiplimab ISA101b 0 1
Cemiplimab + Isatuximab Cemiplimab Isatuximab 0 2
Cemiplimab + JX-594 Cemiplimab JX-594 0 1
Cemiplimab + Odronextamab Cemiplimab Odronextamab 0 1
Cemiplimab + Plerixafor Cemiplimab Plerixafor 0 1
Cemiplimab + Poly ICLC Cemiplimab Poly ICLC 0 1
Cemiplimab + Prednisone + Sirolimus Cemiplimab Prednisone Sirolimus 0 1
Cemiplimab + REGN3767 Cemiplimab REGN3767 1 1
Cemiplimab + REGN4018 Cemiplimab REGN4018 0 1
Cemiplimab + REGN4659 Cemiplimab REGN4659 0 1
Cemiplimab + REGN5668 Cemiplimab REGN5668 0 1
Cemiplimab + REGN5678 Cemiplimab REGN5678 0 1
Cemiplimab + REGN6569 Cemiplimab REGN6569 0 1
Cemiplimab + REGN7075 Cemiplimab REGN7075 0 1
Cemiplimab + RP1 Cemiplimab RP1 0 1
Cemiplimab + SAR439459 Cemiplimab SAR439459 0 2
Cemiplimab + SAR441000 Cemiplimab SAR441000 0 1
Cemiplimab + VSV-hIFNbeta-NIS Cemiplimab VSV-hIFNbeta-NIS 0 1


Additional content available in CKB BOOST