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Drug Name Isatuximab
Trade Name Sarclisa
Synonyms SAR650984|isatuximab-irfc
Drug Descriptions

Sarclisa (isatuximab-irfc) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056). Sarclisa (isatuximab-irfc) in combination with Pomalyst (pomalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received two or more prior therapies (FDA.gov).

DrugClasses CD38 Antibody 7

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Isatuximab Atezolizumab Isatuximab 0 3
Bendamustine + Isatuximab + Prednisone Bendamustine Isatuximab Prednisone 0 1
Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Bortezomib Dexamethasone Isatuximab Lenalidomide 0 1
Carfilzomib + Dexamethasone + Isatuximab Carfilzomib Dexamethasone Isatuximab 0 1
Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Carfilzomib Dexamethasone Isatuximab Lenalidomide 0 1
Carfilzomib + Isatuximab Carfilzomib Isatuximab 0 1
Carfilzomib + Isatuximab + Lenalidomide Carfilzomib Isatuximab Lenalidomide 0 1
Cemiplimab + Isatuximab Cemiplimab Isatuximab 0 2
Dexamethasone + Isatuximab Dexamethasone Isatuximab 0 1
Dexamethasone + Isatuximab + Lenalidomide Dexamethasone Isatuximab Lenalidomide 0 1
Dexamethasone + Isatuximab + Pomalidomide Dexamethasone Isatuximab Pomalidomide 1 3
Diphenhydramine + Isatuximab + Methylprednisolone + Ranitidine Diphenhydramine Isatuximab Methylprednisolone Ranitidine 0 1
Isatuximab Isatuximab 1 6


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