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Drug Name Isatuximab
Trade Name Sarclisa
Synonyms SAR650984|isatuximab-irfc
Drug Descriptions

Sarclisa (isatuximab-irfc) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056). Sarclisa (isatuximab-irfc) in combination with Pomalyst (pomalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received two or more prior therapies, and in combination with Kyprolis (carfilzomib) and dexamethasone for patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy (FDA.gov).

DrugClasses CD38 Antibody 9
CAS Registry Number 1461640-62-9
NCIT ID C90578

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Isatuximab Atezolizumab Isatuximab 0 3
Bendamustine + Isatuximab + Prednisone Bendamustine Isatuximab Prednisone 0 1
Bortezomib + Cyclophosphamide + Dexamethasone + Isatuximab Bortezomib Cyclophosphamide Dexamethasone Isatuximab 0 1
Bortezomib + Dexamethasone + Isatuximab Bortezomib Dexamethasone Isatuximab 0 1
Bortezomib + Dexamethasone + Isatuximab + Lenalidomide Bortezomib Dexamethasone Isatuximab Lenalidomide 0 3
Carfilzomib + Dexamethasone + Isatuximab Carfilzomib Dexamethasone Isatuximab 0 1
Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Carfilzomib Dexamethasone Isatuximab Lenalidomide 0 3
Carfilzomib + Dexamethasone + Isatuximab + Pomalidomide Carfilzomib Dexamethasone Isatuximab Pomalidomide 0 1
Carfilzomib + Isatuximab Carfilzomib Isatuximab 0 1
Carfilzomib + Isatuximab + Lenalidomide Carfilzomib Isatuximab Lenalidomide 0 1
Carfilzomib + Isatuximab + Pomalidomide Carfilzomib Isatuximab Pomalidomide 0 2
Cemiplimab + Isatuximab Cemiplimab Isatuximab 0 2
Dexamethasone + Elotuzumab + Isatuximab + Pomalidomide Dexamethasone Elotuzumab Isatuximab Pomalidomide 0 1
Dexamethasone + Isatuximab Dexamethasone Isatuximab 0 1
Dexamethasone + Isatuximab + Lenalidomide Dexamethasone Isatuximab Lenalidomide 0 4
Dexamethasone + Isatuximab + Pomalidomide Dexamethasone Isatuximab Pomalidomide 0 4
Dexamethasone + Isatuximab + SAR439459 Dexamethasone Isatuximab SAR439459 0 1
Diphenhydramine + Isatuximab + Methylprednisolone + Ranitidine Diphenhydramine Isatuximab Methylprednisolone Ranitidine 0 1
Isatuximab Isatuximab 0 7


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