Drug Detail

Drug Name Isatuximab
Trade Name
Synonyms SAR650984
Drug Descriptions

Isatuximab (SAR650984) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056).

DrugClasses

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Therapy Name Therapy Description
Atezolizumab + Isatuximab
Carfilzomib + Isatuximab
Dexamethasone + Isatuximab + Lenalidomide
Carfilzomib + Dexamethasone + Isatuximab Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (NCI Drug Dictionary). Kyprolis (carfilzomib), in combination with lenalidomide and dexamethasone, is FDA approved for multiple myeloma (FDA.gov).
Isatuximab + REGN2810
Bortezomib + Dexamethasone + Isatuximab + Lenalidomide
Dexamethasone + Isatuximab + Pomalidomide
Isatuximab Isatuximab (SAR650984) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056).
Dexamethasone + Isatuximab
Diphenhydramine + Isatuximab + Methylprednisolone + Ranitidine