Therapy Detail

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Therapy Name Dexamethasone + Isatuximab + Pomalidomide
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Dexamethasone Adexone Desametasone
Isatuximab Sarclisa SAR650984|isatuximab-irfc CD38 Antibody 17 Sarclisa (isatuximab-irfc) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056). Sarclisa (isatuximab-irfc) in combination with Pomalyst (pomalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received two or more prior therapies, and in combination with Kyprolis (carfilzomib) and dexamethasone for patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy (FDA.gov).
Pomalidomide Pomalyst CC-4047 Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov).

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02283775 Phase I Dexamethasone + Isatuximab + Pomalidomide SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients (PomdeSAR) Completed USA 0
NCT04643002 Phase Ib/II Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Isatuximab + SAR439459 Isatuximab in Combination With Novel Agents in RRMM Recruiting USA | ITA | FRA 5
NCT05405166 Phase III Dexamethasone + Isatuximab + Pomalidomide SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM Recruiting USA | ITA | FRA | ESP | CAN 10
NCT02990338 Phase III Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Pomalidomide Multinational Clinical Study Comparing Isatuximab, Pomalidomide, and Dexamethasone to Pomalidomide and Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma Patients (ICARIA-MM) Active, not recruiting USA | ITA | FRA | ESP | DEU | CAN | BEL 17
NCT04045795 Phase I Dexamethasone + Isatuximab + Pomalidomide Multi-center, Open-label, Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM) Active, not recruiting USA | FRA | ESP | BEL 2


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