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|Therapy Name||Dexamethasone + Isatuximab + SAR439459|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Isatuximab||Sarclisa||SAR650984|isatuximab-irfc||CD38 Antibody 16||Sarclisa (isatuximab-irfc) is a humanized monoclonal antibody against CD38 that induces anti-tumor immune reaction against CD38-positive tumor cells (PMID: 24987056). Sarclisa (isatuximab-irfc) in combination with Pomalyst (pomalidomide) and dexamethasone is FDA approved for use in patients with multiple myeloma who have received two or more prior therapies, and in combination with Kyprolis (carfilzomib) and dexamethasone for patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy (FDA.gov).|
|SAR439459||SAR-439459|SAR 439459||TGFB (Pan) Antibody 4||SAR439459 is a monoclonal antibody that targets transforming growth factor beta 1 (TGFB1, TGFbeta), which may lead to tumor regression in combination with PD-1 (PDCD1) immune checkpoint inhibitors (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2790).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04643002||Phase Ib/II||Dexamethasone + Isatuximab + Pomalidomide Dexamethasone + Isatuximab + SAR439459||Isatuximab in Combination With Novel Agents in RRMM||Recruiting||USA | ITA | FRA||5|