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Drug Name Carfilzomib
Trade Name Kyprolis
Synonyms PR-171
Drug Descriptions

Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov).

DrugClasses
CAS Registry Number 868540-17-4
NCIT ID C52196

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afuresertib + Carfilzomib Afuresertib Carfilzomib 0 1
belantamab mafodotin-blmf + Carfilzomib + Dexamethasone Carfilzomib Dexamethasone belantamab mafodotin-blmf 0 1
belantamab mafodotin-blmf + Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib Dexamethasone Lenalidomide belantamab mafodotin-blmf 0 1
belantamab mafodotin-blmf + Carfilzomib + Dexamethasone + Pomalidomide Carfilzomib Dexamethasone Pomalidomide belantamab mafodotin-blmf 0 1
BGB-11417 + Carfilzomib + Dexamethasone BGB-11417 Carfilzomib Dexamethasone 0 1
Birabresib + Carfilzomib Birabresib Carfilzomib 0 0
Bortezomib + Carfilzomib + Clarithromycin Bortezomib Carfilzomib Clarithromycin 0 1
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Carfilzomib Carfilzomib 0 11
Carfilzomib + CC-92480 + Dexamethasone CC-92480 Carfilzomib Dexamethasone 0 2
Carfilzomib + Daratumumab + Dexamethasone Carfilzomib Daratumumab Dexamethasone 0 4
Carfilzomib + Daratumumab + Dexamethasone + Iberdomide Carfilzomib Daratumumab Dexamethasone Iberdomide 0 2
Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Carfilzomib Daratumumab Dexamethasone Lenalidomide 0 6
Carfilzomib + Daratumumab + Dexamethasone + Pomalidomide Carfilzomib Daratumumab Dexamethasone Pomalidomide 0 2
Carfilzomib + Daratumumab + Dexamethasone + Selinexor Carfilzomib Daratumumab Dexamethasone Selinexor 0 1
Carfilzomib + Daratumumab + Lenalidomide Carfilzomib Daratumumab Lenalidomide 0 1
Carfilzomib + Daratumumab + TAK-573 Carfilzomib Daratumumab TAK-573 0 1
Carfilzomib + Daratumumab + Talquetamab-tgvs Carfilzomib Daratumumab Talquetamab-tgvs 0 1
Carfilzomib + Daratumumab and hyaluronidase-fihj + Dexamethasone Carfilzomib Daratumumab and hyaluronidase-fihj Dexamethasone 0 0
Carfilzomib + Dexamethasone Carfilzomib Dexamethasone 0 5
Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide Carfilzomib Dexamethasone Elotuzumab Lenalidomide 0 3
Carfilzomib + Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib Dexamethasone Elotuzumab Pomalidomide 0 1
Carfilzomib + Dexamethasone + Iberdomide Carfilzomib Dexamethasone Iberdomide 0 1
Carfilzomib + Dexamethasone + Isatuximab Carfilzomib Dexamethasone Isatuximab 0 2
Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Carfilzomib Dexamethasone Isatuximab Lenalidomide 0 4
Carfilzomib + Dexamethasone + Isatuximab + Pomalidomide Carfilzomib Dexamethasone Isatuximab Pomalidomide 0 1
Carfilzomib + Dexamethasone + KRT-232 + Lenalidomide Carfilzomib Dexamethasone KRT-232 Lenalidomide 0 1
Carfilzomib + Dexamethasone + Lemzoparlimab Carfilzomib Dexamethasone Lemzoparlimab 0 1
Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib Dexamethasone Lenalidomide 0 8
Carfilzomib + Dexamethasone + Lenalidomide + Panobinostat Carfilzomib Dexamethasone Lenalidomide Panobinostat 0 1
Carfilzomib + Dexamethasone + Linvoseltamab Carfilzomib Dexamethasone Linvoseltamab 0 1
Carfilzomib + Dexamethasone + Nivolumab Carfilzomib Dexamethasone Nivolumab 0 1
Carfilzomib + Dexamethasone + Nivolumab + Pelareorep Carfilzomib Dexamethasone Nivolumab Pelareorep 0 1
Carfilzomib + Dexamethasone + Panobinostat Carfilzomib Dexamethasone Panobinostat 0 1
Carfilzomib + Dexamethasone + Pelareorep Carfilzomib Dexamethasone Pelareorep 0 1
Carfilzomib + Dexamethasone + Pomalidomide Carfilzomib Dexamethasone Pomalidomide 0 1
Carfilzomib + Dexamethasone + Pomalidomide + Selinexor Carfilzomib Dexamethasone Pomalidomide Selinexor 0 1
Carfilzomib + Dexamethasone + Ruxolitinib Carfilzomib Dexamethasone Ruxolitinib 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 4
Carfilzomib + Dexamethasone + Thalidomide Carfilzomib Dexamethasone Thalidomide 0 1
Carfilzomib + Dexamethasone + Venetoclax Carfilzomib Dexamethasone Venetoclax 0 1
Carfilzomib + DT204 Carfilzomib DT204 0 0
Carfilzomib + Elranatamab-bcmm Carfilzomib Elranatamab-bcmm 0 1
Carfilzomib + HDP-101 Carfilzomib HDP-101 0 0
Carfilzomib + Ibrutinib Carfilzomib Ibrutinib 0 3
Carfilzomib + Isatuximab Carfilzomib Isatuximab 0 1
Carfilzomib + Isatuximab + Lenalidomide Carfilzomib Isatuximab Lenalidomide 0 1
Carfilzomib + Isatuximab + Pomalidomide Carfilzomib Isatuximab Pomalidomide 0 2
Carfilzomib + Molibresib Carfilzomib Molibresib 0 0
Carfilzomib + Panobinostat Carfilzomib Panobinostat 0 1
Carfilzomib + Pomalidomide + TAK-573 Carfilzomib Pomalidomide TAK-573 0 1
Carfilzomib + Ricolinostat Carfilzomib Ricolinostat 0 0
Carfilzomib + Rituximab Carfilzomib Rituximab 0 2
Carfilzomib + RO7425781 Carfilzomib RO7425781 0 1
Carfilzomib + Selinexor Carfilzomib Selinexor 0 0
Carfilzomib + Sotorasib Carfilzomib Sotorasib 0 1
Carfilzomib + TAK-573 Carfilzomib TAK-573 0 1
Carfilzomib + Talquetamab-tgvs Carfilzomib Talquetamab-tgvs 0 1
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 0 0
Carfilzomib + Umbralisib Carfilzomib Umbralisib 0 1
Carfilzomib + Zotiraciclib Carfilzomib Zotiraciclib 0 0


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