Drug Detail

Drug Name Carfilzomib
Trade Name Kyprolis
Synonyms PR-171
Drug Descriptions

Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (NCI Drug Dictionary). Kyprolis (carfilzomib), in combination with lenalidomide and dexamethasone, is FDA approved for multiple myeloma (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afuresertib + Carfilzomib Afuresertib Carfilzomib 0 1
AMG 232 + Carfilzomib + Dexamethasone + Lenalidomide AMG 232 Carfilzomib Dexamethasone Lenalidomide 0 1
Bortezomib + Carfilzomib + Clarithromycin Bortezomib Carfilzomib Clarithromycin 0 1
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Carfilzomib Carfilzomib 1 10
Carfilzomib + Dexamethasone Carfilzomib Dexamethasone 0 1
Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide Carfilzomib Dexamethasone Elotuzumab Lenalidomide 0 2
Carfilzomib + Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib Dexamethasone Elotuzumab Pomalidomide 0 1
Carfilzomib + Dexamethasone + Isatuximab Carfilzomib Dexamethasone Isatuximab 0 1
Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib Dexamethasone Lenalidomide 0 1
Carfilzomib + Dexamethasone + Lenalidomide + Panobinostat Carfilzomib Dexamethasone Lenalidomide Panobinostat 0 1
Carfilzomib + Dexamethasone + Nivolumab Carfilzomib Dexamethasone Nivolumab 0 1
Carfilzomib + Dexamethasone + Nivolumab + Reolysin Carfilzomib Dexamethasone Nivolumab Reolysin 0 1
Carfilzomib + Dexamethasone + Panobinostat Carfilzomib Dexamethasone Panobinostat 0 1
Carfilzomib + Dexamethasone + Reolysin Carfilzomib Dexamethasone Reolysin 0 1
Carfilzomib + Dexamethasone + Ruxolitinib Carfilzomib Dexamethasone Ruxolitinib 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 2
Carfilzomib + Dexamethasone + Venetoclax Carfilzomib Dexamethasone Venetoclax 0 1
Carfilzomib + DT204 Carfilzomib DT204 1 0
Carfilzomib + Ibrutinib Carfilzomib Ibrutinib 0 2
Carfilzomib + Isatuximab Carfilzomib Isatuximab 0 1
Carfilzomib + Panobinostat Carfilzomib Panobinostat 0 1
Carfilzomib + Ricolinostat Carfilzomib Ricolinostat 1 0
Carfilzomib + Rituximab Carfilzomib Rituximab 0 2
Carfilzomib + Selinexor Carfilzomib Selinexor 2 0
Carfilzomib + TG02 Carfilzomib TG02 1 0
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 7 0
Carfilzomib + Umbralisib Carfilzomib Umbralisib 0 1