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Drug Name Carfilzomib
Trade Name Kyprolis
Synonyms PR-171
Drug Descriptions

Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov).

DrugClasses
CAS Registry Number 868540-17-4
NCIT ID C52196

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afuresertib + Carfilzomib Afuresertib Carfilzomib 0 1
belantamab mafodotin-blmf + Carfilzomib + Dexamethasone Carfilzomib Dexamethasone belantamab mafodotin-blmf 0 1
BGB-11417 + Carfilzomib + Dexamethasone BGB-11417 Carfilzomib Dexamethasone 0 1
Birabresib + Carfilzomib Birabresib Carfilzomib 0 0
Bortezomib + Carfilzomib + Clarithromycin Bortezomib Carfilzomib Clarithromycin 0 1
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Carfilzomib Carfilzomib 0 10
Carfilzomib + CC-92480 + Dexamethasone CC-92480 Carfilzomib Dexamethasone 0 1
Carfilzomib + Daratumumab + Dexamethasone Carfilzomib Daratumumab Dexamethasone 0 3
Carfilzomib + Daratumumab + Dexamethasone + Iberdomide Carfilzomib Daratumumab Dexamethasone Iberdomide 0 1
Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Carfilzomib Daratumumab Dexamethasone Lenalidomide 0 5
Carfilzomib + Daratumumab + Dexamethasone + Pomalidomide Carfilzomib Daratumumab Dexamethasone Pomalidomide 0 2
Carfilzomib + Daratumumab + Dexamethasone + Selinexor Carfilzomib Daratumumab Dexamethasone Selinexor 0 1
Carfilzomib + Daratumumab + Talquetamab Carfilzomib Daratumumab Talquetamab 0 1
Carfilzomib + Daratumumab and hyaluronidase-fihj + Dexamethasone Carfilzomib Daratumumab and hyaluronidase-fihj Dexamethasone 0 0
Carfilzomib + Dexamethasone Carfilzomib Dexamethasone 0 2
Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide Carfilzomib Dexamethasone Elotuzumab Lenalidomide 0 3
Carfilzomib + Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib Dexamethasone Elotuzumab Pomalidomide 0 1
Carfilzomib + Dexamethasone + Iberdomide Carfilzomib Dexamethasone Iberdomide 0 1
Carfilzomib + Dexamethasone + Isatuximab Carfilzomib Dexamethasone Isatuximab 0 1
Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Carfilzomib Dexamethasone Isatuximab Lenalidomide 0 4
Carfilzomib + Dexamethasone + Isatuximab + Pomalidomide Carfilzomib Dexamethasone Isatuximab Pomalidomide 0 1
Carfilzomib + Dexamethasone + KRT-232 + Lenalidomide Carfilzomib Dexamethasone KRT-232 Lenalidomide 0 1
Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib Dexamethasone Lenalidomide 0 7
Carfilzomib + Dexamethasone + Lenalidomide + Panobinostat Carfilzomib Dexamethasone Lenalidomide Panobinostat 0 1
Carfilzomib + Dexamethasone + Nivolumab Carfilzomib Dexamethasone Nivolumab 0 1
Carfilzomib + Dexamethasone + Nivolumab + Pelareorep Carfilzomib Dexamethasone Nivolumab Pelareorep 0 1
Carfilzomib + Dexamethasone + Panobinostat Carfilzomib Dexamethasone Panobinostat 0 1
Carfilzomib + Dexamethasone + Pelareorep Carfilzomib Dexamethasone Pelareorep 0 1
Carfilzomib + Dexamethasone + Pomalidomide Carfilzomib Dexamethasone Pomalidomide 0 1
Carfilzomib + Dexamethasone + Pomalidomide + Selinexor Carfilzomib Dexamethasone Pomalidomide Selinexor 0 1
Carfilzomib + Dexamethasone + REGN5458 Carfilzomib Dexamethasone REGN5458 0 1
Carfilzomib + Dexamethasone + Ruxolitinib Carfilzomib Dexamethasone Ruxolitinib 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 4
Carfilzomib + Dexamethasone + Thalidomide Carfilzomib Dexamethasone Thalidomide 0 1
Carfilzomib + Dexamethasone + TJ011133 Carfilzomib Dexamethasone TJ011133 0 1
Carfilzomib + Dexamethasone + Venetoclax Carfilzomib Dexamethasone Venetoclax 0 1
Carfilzomib + DT204 Carfilzomib DT204 0 0
Carfilzomib + HDP-101 Carfilzomib HDP-101 0 0
Carfilzomib + Ibrutinib Carfilzomib Ibrutinib 0 2
Carfilzomib + Isatuximab Carfilzomib Isatuximab 0 1
Carfilzomib + Isatuximab + Lenalidomide Carfilzomib Isatuximab Lenalidomide 0 1
Carfilzomib + Isatuximab + Pomalidomide Carfilzomib Isatuximab Pomalidomide 0 2
Carfilzomib + Molibresib Carfilzomib Molibresib 0 0
Carfilzomib + Panobinostat Carfilzomib Panobinostat 0 1
Carfilzomib + Ricolinostat Carfilzomib Ricolinostat 0 0
Carfilzomib + Rituximab Carfilzomib Rituximab 0 2
Carfilzomib + Selinexor Carfilzomib Selinexor 0 0
Carfilzomib + Talquetamab Carfilzomib Talquetamab 0 1
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 0 0
Carfilzomib + Umbralisib Carfilzomib Umbralisib 0 1
Carfilzomib + Zotiraciclib Carfilzomib Zotiraciclib 0 0


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