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Drug Name Carfilzomib
Trade Name Kyprolis
Synonyms PR-171
Drug Descriptions

Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells. Kyprolis (carfilzomib), in combination with lenalidomide and dexamethasone, is FDA approved for multiple myeloma (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afuresertib + Carfilzomib Afuresertib Carfilzomib 0 1
Bortezomib + Carfilzomib + Clarithromycin Bortezomib Carfilzomib Clarithromycin 0 1
Cabozantinib + Carfilzomib + Dexamethasone Cabozantinib Carfilzomib Dexamethasone 0 1
Carfilzomib Carfilzomib 1 10
Carfilzomib + CC-92480 + Dexamethasone CC-92480 Carfilzomib Dexamethasone 0 1
Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Carfilzomib Daratumumab Dexamethasone Lenalidomide 0 1
Carfilzomib + Dexamethasone Carfilzomib Dexamethasone 0 1
Carfilzomib + Dexamethasone + Elotuzumab + Lenalidomide Carfilzomib Dexamethasone Elotuzumab Lenalidomide 0 2
Carfilzomib + Dexamethasone + Elotuzumab + Pomalidomide Carfilzomib Dexamethasone Elotuzumab Pomalidomide 0 1
Carfilzomib + Dexamethasone + Isatuximab Carfilzomib Dexamethasone Isatuximab 0 1
Carfilzomib + Dexamethasone + Isatuximab + Lenalidomide Carfilzomib Dexamethasone Isatuximab Lenalidomide 0 1
Carfilzomib + Dexamethasone + KRT-232 + Lenalidomide Carfilzomib Dexamethasone KRT-232 Lenalidomide 0 1
Carfilzomib + Dexamethasone + Lenalidomide Carfilzomib Dexamethasone Lenalidomide 0 2
Carfilzomib + Dexamethasone + Lenalidomide + Panobinostat Carfilzomib Dexamethasone Lenalidomide Panobinostat 0 1
Carfilzomib + Dexamethasone + Nivolumab Carfilzomib Dexamethasone Nivolumab 0 1
Carfilzomib + Dexamethasone + Nivolumab + Pelareorep Carfilzomib Dexamethasone Nivolumab Pelareorep 0 1
Carfilzomib + Dexamethasone + Panobinostat Carfilzomib Dexamethasone Panobinostat 0 1
Carfilzomib + Dexamethasone + Pelareorep Carfilzomib Dexamethasone Pelareorep 0 1
Carfilzomib + Dexamethasone + Ruxolitinib Carfilzomib Dexamethasone Ruxolitinib 0 1
Carfilzomib + Dexamethasone + Selinexor Carfilzomib Dexamethasone Selinexor 0 2
Carfilzomib + Dexamethasone + Venetoclax Carfilzomib Dexamethasone Venetoclax 0 1
Carfilzomib + DT204 Carfilzomib DT204 1 0
Carfilzomib + Ibrutinib Carfilzomib Ibrutinib 0 2
Carfilzomib + Isatuximab Carfilzomib Isatuximab 0 1
Carfilzomib + Isatuximab + Lenalidomide Carfilzomib Isatuximab Lenalidomide 0 1
Carfilzomib + Panobinostat Carfilzomib Panobinostat 0 1
Carfilzomib + Ricolinostat Carfilzomib Ricolinostat 1 0
Carfilzomib + Rituximab Carfilzomib Rituximab 0 2
Carfilzomib + Selinexor Carfilzomib Selinexor 2 0
Carfilzomib + Tinostamustine Carfilzomib Tinostamustine 7 0
Carfilzomib + Umbralisib Carfilzomib Umbralisib 0 1
Carfilzomib + Zotiraciclib Carfilzomib Zotiraciclib 1 0


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