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Drug Name Elranatamab-bcmm
Trade Name Elrexfio
Synonyms PF-06863135|PF06863135|PF 06863135
Drug Descriptions

Elrexfio (elranatamab-bcmm) is a bispecific antibody that binds to both TNFRSF17 (BCMA) and CD3, thereby crosslinking BCMA-expressing tumor cells and cytotoxic T-lymphocytes, potentially resulting in increased immune response against BCMA-expressing tumor cells (J Clin Oncol 39, no. 15_suppl (May 20, 2020) 8006-8006). Elrexfio (elranatamab-bcmm) is FDA -approved for use in patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy (FDA.gov).

DrugClasses CD3 Antibody 94 TNFRSF17 Antibody 18
CAS Registry Number NA
NCIT ID C146860

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carfilzomib + Elranatamab-bcmm Carfilzomib Elranatamab-bcmm 0 1
Cevostamab + Elranatamab-bcmm Cevostamab Elranatamab-bcmm 0 1
Daratumumab + Elranatamab-bcmm Daratumumab Elranatamab-bcmm 0 1
Daratumumab + Elranatamab-bcmm + Lenalidomide Daratumumab Elranatamab-bcmm Lenalidomide 0 1
Elranatamab-bcmm Elranatamab-bcmm 0 13
Elranatamab-bcmm + Iberdomide Elranatamab-bcmm Iberdomide 0 1
Elranatamab-bcmm + Nirogacestat Elranatamab-bcmm Nirogacestat 0 1


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