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Drug Name Iberdomide
Trade Name
Synonyms CC220|CC-220|CC 220
Drug Descriptions

Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682).

DrugClasses
CAS Registry Number 1323403-33-3
NCIT ID C129048

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Iberdomide + Polatuzumab vedotin-piiq + Rituximab Bendamustine Iberdomide Polatuzumab vedotin-piiq Rituximab 0 0
Bortezomib + Dexamethasone + Iberdomide Bortezomib Dexamethasone Iberdomide 0 1
Cisplatin + Dexamethasone + Gemcitabine + Iberdomide + Rituximab Cisplatin Dexamethasone Gemcitabine Iberdomide Rituximab 0 1
Cyclophosphamide + Doxorubicin + Iberdomide + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Iberdomide Prednisone Rituximab Vincristine Sulfate 0 1
Daratumumab + Dexamethasone + Iberdomide Daratumumab Dexamethasone Iberdomide 0 2
Dexamethasone + Iberdomide Dexamethasone Iberdomide 0 2
Iberdomide Iberdomide 0 4
Iberdomide + Idecabtagene Vicleucel Iberdomide Idecabtagene Vicleucel 0 1
Iberdomide + Lenalidomide + Tafasitamab-cxix Iberdomide Lenalidomide Tafasitamab-cxix 0 0
Iberdomide + Obinutuzumab Iberdomide Obinutuzumab 0 1
Iberdomide + Polatuzumab vedotin-piiq + Rituximab Iberdomide Polatuzumab vedotin-piiq Rituximab 0 1
Iberdomide + Rituximab Iberdomide Rituximab 0 1
Iberdomide + Tafasitamab-cxix Iberdomide Tafasitamab-cxix 0 1


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