Drug Detail


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Drug Name Iberdomide
Trade Name
Synonyms CRL4 cereblon E3 ubiquitin ligase modulator CC-220|CC220|CC-220
Drug Descriptions

Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067).



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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Dexamethasone + Iberdomide Bortezomib Dexamethasone Iberdomide 0 1
Daratumumab + Dexamethasone + Iberdomide Daratumumab Dexamethasone Iberdomide 0 1
Dexamethasone + Iberdomide Dexamethasone Iberdomide 0 1
Iberdomide Iberdomide 0 2
Iberdomide + Obinutuzumab Iberdomide Obinutuzumab 0 1
Iberdomide + Rituximab Iberdomide Rituximab 0 1

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