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Drug Name Daratumumab
Trade Name Darzalex
Synonyms JNJ-54767414
Drug Descriptions

Darzalex (Daratumumab) is a human antibody against CD38 that induces antibody-dependent cell-mediated cytotoxicity and complement-mediated cytotoxicity against CD38-positive tumor cells (PMID: 30546360). Darzalex (Daratumumab) is FDA approved for multiple myeloma patients as a monotherapy or in combination with lenalidomide and dexamethasone, or with bortezomib and dexamethasone, or with bortezomib, melphalan, and prednisone, or with pomalidomide and dexamethasone, or with bortezomib, thalidomide and dexamethasone (FDA.gov).

DrugClasses CD38 Antibody 15
CAS Registry Number 945721-28-8
NCIT ID C74007

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Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-2575 + Daratumumab + Dexamethasone + Lenalidomide APG-2575 Daratumumab Dexamethasone Lenalidomide 0 1
Atezolizumab + Daratumumab Atezolizumab Daratumumab 0 1
Azacitidine + Daratumumab + Dexamethasone Azacitidine Daratumumab Dexamethasone 0 1
belantamab mafodotin-blmf + Daratumumab + Dexamethasone + Lenalidomide Daratumumab Dexamethasone Lenalidomide belantamab mafodotin-blmf 0 1
belantamab mafodotin-blmf + Daratumumab + Lenalidomide Daratumumab Lenalidomide belantamab mafodotin-blmf 0 1
Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone Bortezomib Cyclophosphamide Daratumumab Dexamethasone 0 3
Bortezomib + Daratumumab + Dexamethasone Bortezomib Daratumumab Dexamethasone 0 9
Bortezomib + Daratumumab + Dexamethasone + Iberdomide Bortezomib Daratumumab Dexamethasone Iberdomide 0 1
Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Bortezomib Daratumumab Dexamethasone Lenalidomide 0 8
Bortezomib + Daratumumab + Dexamethasone + Melphalan + Prednisone Bortezomib Daratumumab Dexamethasone Melphalan Prednisone 0 1
Bortezomib + Daratumumab + Dexamethasone + Selinexor Bortezomib Daratumumab Dexamethasone Selinexor 0 1
Bortezomib + Daratumumab + Dexamethasone + Thalidomide Bortezomib Daratumumab Dexamethasone Thalidomide 0 1
Bortezomib + Daratumumab + Dexamethasone + Venetoclax Bortezomib Daratumumab Dexamethasone Venetoclax 0 2
Bortezomib + Daratumumab + Lenalidomide + Teclistamab Bortezomib Daratumumab Lenalidomide Teclistamab 0 1
Bortezomib + Daratumumab + Melphalan Bortezomib Daratumumab Melphalan 0 0
Bortezomib + Daratumumab + Melphalan + Prednisone Bortezomib Daratumumab Melphalan Prednisone 0 0
Carfilzomib + Daratumumab + Dexamethasone Carfilzomib Daratumumab Dexamethasone 0 3
Carfilzomib + Daratumumab + Dexamethasone + Iberdomide Carfilzomib Daratumumab Dexamethasone Iberdomide 0 1
Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Carfilzomib Daratumumab Dexamethasone Lenalidomide 0 6
Carfilzomib + Daratumumab + Dexamethasone + Pomalidomide Carfilzomib Daratumumab Dexamethasone Pomalidomide 0 2
Carfilzomib + Daratumumab + Dexamethasone + Selinexor Carfilzomib Daratumumab Dexamethasone Selinexor 0 1
Carfilzomib + Daratumumab + Lenalidomide Carfilzomib Daratumumab Lenalidomide 0 1
Carfilzomib + Daratumumab + Talquetamab Carfilzomib Daratumumab Talquetamab 0 1
CC-92480 + Daratumumab + Dexamethasone CC-92480 Daratumumab Dexamethasone 0 1
Cetrelimab + Daratumumab Cetrelimab Daratumumab 0 1
Ciltacabtagene autoleucel + Cyclophosphamide + Daratumumab + Dexamethasone + Fludarabine + Pomalidomide Ciltacabtagene autoleucel Cyclophosphamide Daratumumab Dexamethasone Fludarabine Pomalidomide 0 1
Clarithromycin + Daratumumab + Dexamethasone + Pomalidomide Clarithromycin Daratumumab Dexamethasone Pomalidomide 0 1
CPI-444 + Daratumumab CPI-444 Daratumumab 0 1
Cyclophosphamide + Daratumumab + Doxorubicin + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide Daratumumab Doxorubicin Etoposide Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Daratumumab + Mycophenolate mofetil + Tacrolimus Cyclophosphamide Daratumumab Mycophenolate mofetil Tacrolimus 0 1
Daratumumab Daratumumab 0 22
Daratumumab + Dexamethasone Daratumumab Dexamethasone 0 2
Daratumumab + Dexamethasone + Durvalumab + Pomalidomide Daratumumab Dexamethasone Durvalumab Pomalidomide 0 1
Daratumumab + Dexamethasone + Iberdomide Daratumumab Dexamethasone Iberdomide 0 3
Daratumumab + Dexamethasone + Ixazomib Daratumumab Dexamethasone Ixazomib 0 2
Daratumumab + Dexamethasone + Ixazomib + Lenalidomide Daratumumab Dexamethasone Ixazomib Lenalidomide 0 2
Daratumumab + Dexamethasone + Ixazomib + Pomalidomide Daratumumab Dexamethasone Ixazomib Pomalidomide 0 1
Daratumumab + Dexamethasone + Lenalidomide Daratumumab Dexamethasone Lenalidomide 0 10
Daratumumab + Dexamethasone + Lenalidomide + Selinexor Daratumumab Dexamethasone Lenalidomide Selinexor 0 1
Daratumumab + Dexamethasone + Melflufen Daratumumab Dexamethasone Melflufen 0 2
Daratumumab + Dexamethasone + Pomalidomide Daratumumab Dexamethasone Pomalidomide 0 6
Daratumumab + Dexamethasone + Pomalidomide + Talquetamab Daratumumab Dexamethasone Pomalidomide Talquetamab 0 1
Daratumumab + Dexamethasone + Pomalidomide + Tazemetostat Daratumumab Dexamethasone Pomalidomide Tazemetostat 0 1
Daratumumab + Dexamethasone + Pomalidomide + Tretinoin Daratumumab Dexamethasone Pomalidomide Tretinoin 0 1
Daratumumab + Dexamethasone + REGN5458 Daratumumab Dexamethasone REGN5458 0 1
Daratumumab + Dexamethasone + Selinexor Daratumumab Dexamethasone Selinexor 0 2
Daratumumab + Dexamethasone + Talquetamab Daratumumab Dexamethasone Talquetamab 0 1
Daratumumab + Dexamethasone + TJ011133 Daratumumab Dexamethasone TJ011133 0 1
Daratumumab + Dexamethasone + TNB-383B Daratumumab Dexamethasone TNB-383B 0 1
Daratumumab + Dexamethasone + Venetoclax Daratumumab Dexamethasone Venetoclax 0 1
Daratumumab + Durvalumab Daratumumab Durvalumab 0 2
Daratumumab + Elranatamab Daratumumab Elranatamab 0 1
Daratumumab + FT538 Daratumumab FT538 0 1
Daratumumab + FT576 Daratumumab FT576 0 1
Daratumumab + Hu5F9-G4 Daratumumab Hu5F9-G4 0 1
Daratumumab + Ibrutinib Daratumumab Ibrutinib 0 4
Daratumumab + INCB001158 Daratumumab INCB001158 0 1
Daratumumab + Ixazomib Daratumumab Ixazomib 0 2
Daratumumab + Lenalidomide Daratumumab Lenalidomide 0 7
Daratumumab + Lenalidomide + rHuPH20 Daratumumab Lenalidomide rHuPH20 0 1
Daratumumab + Lenalidomide + Talquetamab Daratumumab Lenalidomide Talquetamab 0 1
Daratumumab + Nivolumab Daratumumab Nivolumab 0 1
Daratumumab + NKTR-255 Daratumumab NKTR-255 0 1
Daratumumab + Pembrolizumab Daratumumab Pembrolizumab 0 2
Daratumumab + Pomalidomide Daratumumab Pomalidomide 0 0
Daratumumab + Pomalidomide + Teclistamab Daratumumab Pomalidomide Teclistamab 0 1
Daratumumab + rHuPH20 Daratumumab rHuPH20 0 2
Daratumumab + RO7310729 Daratumumab RO7310729 0 1
Daratumumab + Talquetamab Daratumumab Talquetamab 0 1
Daratumumab + Teclistamab Daratumumab Teclistamab 0 2
Daratumumab + TEN-010 Daratumumab TEN-010 0 1
Daratumumab + Tiragolumab Daratumumab Tiragolumab 0 1
Daratumumab + TTI-621 Daratumumab TTI-621 0 1
Daratumumab + TTI-622 Daratumumab TTI-622 0 1


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