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Drug Name Daratumumab
Trade Name Darzalex
Synonyms JNJ-54767414
Drug Descriptions

Darzalex (Daratumumab) is a human antibody against CD38 that induces antibody-dependent cell-mediated cytotoxicity and complement-mediated cytotoxicity against CD38-positive tumor cells (PMID: 30546360). Darzalex (Daratumumab) is FDA approved for multiple myeloma patients as a monotherapy or in combination with lenalidomide and dexamethasone, or with bortezomib and dexamethasone, or with bortezomib, melphalan, and prednisone, or with pomalidomide and dexamethasone, or with bortezomib, thalidomide and dexamethasone (FDA.gov).

DrugClasses CD38 Antibody 7

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Daratumumab Atezolizumab Daratumumab 0 1
Bortezomib + Cyclophosphamide + Daratumumab + Dexamethasone Bortezomib Cyclophosphamide Daratumumab Dexamethasone 0 1
Bortezomib + Daratumumab + Dexamethasone Bortezomib Daratumumab Dexamethasone 1 5
Bortezomib + Daratumumab + Dexamethasone + Lenalidomide Bortezomib Daratumumab Dexamethasone Lenalidomide 0 5
Bortezomib + Daratumumab + Dexamethasone + Melphalan + Prednisone Bortezomib Daratumumab Dexamethasone Melphalan Prednisone 0 1
Bortezomib + Daratumumab + Dexamethasone + Thalidomide Bortezomib Daratumumab Dexamethasone Thalidomide 1 1
Bortezomib + Daratumumab + Dexamethasone + Venetoclax Bortezomib Daratumumab Dexamethasone Venetoclax 0 2
Bortezomib + Daratumumab + Melphalan Bortezomib Daratumumab Melphalan 0 0
Bortezomib + Daratumumab + Melphalan + Prednisone Bortezomib Daratumumab Melphalan Prednisone 1 0
Carfilzomib + Daratumumab + Dexamethasone + Lenalidomide Carfilzomib Daratumumab Dexamethasone Lenalidomide 0 1
CC-92480 + Daratumumab + Dexamethasone CC-92480 Daratumumab Dexamethasone 0 1
CPI-444 + Daratumumab CPI-444 Daratumumab 0 1
Cyclophosphamide + Daratumumab + Dexamethasone + Fludarabine + JNJ-68284528 + Pomalidomide Cyclophosphamide Daratumumab Dexamethasone Fludarabine JNJ-68284528 Pomalidomide 0 1
Cyclophosphamide + Daratumumab + Doxorubicin + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide Daratumumab Doxorubicin Etoposide Prednisone Vincristine Sulfate 0 1
Cyclophosphamide + Daratumumab + Mycophenolate mofetil + Tacrolimus Cyclophosphamide Daratumumab Mycophenolate mofetil Tacrolimus 0 1
Daratumumab Daratumumab 1 16
Daratumumab + Dexamethasone Daratumumab Dexamethasone 0 2
Daratumumab + Dexamethasone + Durvalumab + Pomalidomide Daratumumab Dexamethasone Durvalumab Pomalidomide 0 1
Daratumumab + Dexamethasone + Iberdomide Daratumumab Dexamethasone Iberdomide 0 1
Daratumumab + Dexamethasone + Ixazomib Daratumumab Dexamethasone Ixazomib 0 2
Daratumumab + Dexamethasone + Ixazomib + Pomalidomide Daratumumab Dexamethasone Ixazomib Pomalidomide 0 1
Daratumumab + Dexamethasone + Lenalidomide Daratumumab Dexamethasone Lenalidomide 2 5
Daratumumab + Dexamethasone + Melflufen Daratumumab Dexamethasone Melflufen 0 1
Daratumumab + Dexamethasone + Pomalidomide Daratumumab Dexamethasone Pomalidomide 1 3
Daratumumab + Dexamethasone + Venetoclax Daratumumab Dexamethasone Venetoclax 0 1
Daratumumab + Durvalumab Daratumumab Durvalumab 0 2
Daratumumab + Ibrutinib Daratumumab Ibrutinib 0 3
Daratumumab + INCB001158 Daratumumab INCB001158 0 1
Daratumumab + Ixazomib Daratumumab Ixazomib 0 1
Daratumumab + JNJ-63723283 Daratumumab JNJ-63723283 0 1
Daratumumab + JNJ-64007957 Daratumumab JNJ-64007957 0 1
Daratumumab + JNJ-64407564 Daratumumab JNJ-64407564 0 1
Daratumumab + Lenalidomide Daratumumab Lenalidomide 0 4
Daratumumab + Lenalidomide + rHuPH20 Daratumumab Lenalidomide rHuPH20 0 1
Daratumumab + MTIG7192A Daratumumab MTIG7192A 0 1
Daratumumab + Nivolumab Daratumumab Nivolumab 0 1
Daratumumab + NKTR-255 Daratumumab NKTR-255 0 1
Daratumumab + Pembrolizumab Daratumumab Pembrolizumab 0 1
Daratumumab + rHuPH20 Daratumumab rHuPH20 0 2
Daratumumab + TEN-010 Daratumumab TEN-010 0 1


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