Drug Detail

Drug Name Tretinoin
Trade Name
Synonyms Aberel|Aknoten|Avita|Renova|Retin-A|all-trans retinoic acid|Vitamin A Acid|ATRA
Drug Descriptions

Tretinoin is a form of retinoic acid, which binds to retinoic acid receptors and activates downstream signaling, potentially inducing cell differentiation and subsequently, apoptosis (PMID: 11704842). Tretinoin is FDA approved for patients with acute promyelocytic leukemia harboring PML-RARA (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin Arsenic trioxide Cytarabine Methotrexate Tretinoin 1 0
Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Arsenic trioxide Gemtuzumab ozogamicin Tretinoin 0 2
Arsenic trioxide + Tretinoin Arsenic trioxide Tretinoin 1 0
Azacitidine + Leuprolide + Tretinoin Azacitidine Leuprolide Tretinoin 0 1
Celecoxib + Itraconazole + Tretinoin Celecoxib Itraconazole Tretinoin 0 1
Dasatinib + Tretinoin Dasatinib Tretinoin 0 0
Pembrolizumab + Tretinoin Pembrolizumab Tretinoin 0 1
RN-1 + Tretinoin RN-1 Tretinoin 1 0
Tranylcypromine + Tretinoin Tranylcypromine Tretinoin 0 1
Trastuzumab + Tretinoin Trastuzumab Tretinoin 0 0
Tretinoin Tretinoin 2 5


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