Drug Detail

Drug Name Dasatinib
Trade Name Sprycel
Synonyms BMS-354825
Drug Descriptions

Sprycel (dasatinib) is an inhibitor of the SRC-family of protein kinases, BCR-ABL, and ABL, and has additional activity against other kinases including KIT, DDR1/2, PDGFRA/B, and EPHA2, which prevents cell growth (PMID: 25709401, PMID: 25284748, PMID: 18797457). Sprycel (dasatinib) is FDA approved for both Philadelphia chromosome positive adult and pediatric chronic myelogenous leukemia and adult acute lymphoblastic leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 8 BCR-ABL Inhibitor 24 BTK inhibitor 20 CSF1R Inhibitor 23 DDR1 Inhibitor 8 DDR2 inhibitor 7 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 SRC Inhibitor 27 TNK2 Inhibitor 6

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Dasatinib Abiraterone Dasatinib 0 1
Afatinib + Dasatinib Afatinib Dasatinib 0 1
Asciminib + Dasatinib Asciminib Dasatinib 0 0
Asciminib + Dasatinib + Prednisone Asciminib Dasatinib Prednisone 0 1
Bexarotene + Dasatinib Bexarotene Dasatinib 0 0
BIRB-796 + Dasatinib BIRB-796 Dasatinib 1 0
Bortezomib + Dasatinib + Dexamethasone + Doxorubicin + Palbociclib Bortezomib Dasatinib Dexamethasone Doxorubicin Palbociclib 0 1
BP1001 + Dasatinib BP1001 Dasatinib 0 1
Carboplatin + Dasatinib + Paclitaxel Carboplatin Dasatinib Paclitaxel 0 1
Cetuximab + Dasatinib Cetuximab Dasatinib 1 1
Cetuximab + Dasatinib + Fluorouracil + Leucovorin + Oxaliplatin Cetuximab Dasatinib Fluorouracil Leucovorin Oxaliplatin 0 0
Crizotinib + Dasatinib Crizotinib Dasatinib 1 2
Cyclophosphamide + Dasatinib + Temsirolimus Cyclophosphamide Dasatinib Temsirolimus 0 1
Cytarabine + Dasatinib Cytarabine Dasatinib 1 0
Cytarabine + Dasatinib + Fludarabine + Idarubicin Cytarabine Dasatinib Fludarabine Idarubicin 0 1
Cytarabine + Dasatinib + Idarubicin Cytarabine Dasatinib Idarubicin 0 1
Dasatinib Dasatinib 62 45
Dasatinib + Decitabine Dasatinib Decitabine 0 1
Dasatinib + Demcizumab Dasatinib Demcizumab 0 0
Dasatinib + Dexamethasone + Ruxolitinib Dasatinib Dexamethasone Ruxolitinib 0 1
Dasatinib + Erlotinib Dasatinib Erlotinib 1 0
Dasatinib + Erlotinib + Gemcitabine Dasatinib Erlotinib Gemcitabine 0 1
Dasatinib + ETC-1907206 Dasatinib ETC-1907206 0 1
Dasatinib + Everolimus Dasatinib Everolimus 0 1
Dasatinib + Fludarabine + Rituximab Dasatinib Fludarabine Rituximab 0 1
Dasatinib + Fluorouracil + Leucovorin + Oxaliplatin Dasatinib Fluorouracil Leucovorin Oxaliplatin 0 0
Dasatinib + Fulvestrant Dasatinib Fulvestrant 0 0
Dasatinib + Ganitumab Dasatinib Ganitumab 0 1
Dasatinib + Gefitinib Dasatinib Gefitinib 0 0
Dasatinib + GSK343 Dasatinib GSK343 1 0
Dasatinib + Ibrutinib + Prednisone Dasatinib Ibrutinib Prednisone 0 1
Dasatinib + Ipilimumab Dasatinib Ipilimumab 0 1
Dasatinib + JQ1 Dasatinib JQ1 0 0
Dasatinib + Lapatinib Dasatinib Lapatinib 0 0
Dasatinib + Lenalidomide Dasatinib Lenalidomide 0 1
Dasatinib + Nivolumab Dasatinib Nivolumab 0 3
Dasatinib + Osimertinib Dasatinib Osimertinib 3 1
Dasatinib + Pembrolizumab Dasatinib Pembrolizumab 0 1
Dasatinib + Pri-724 Dasatinib Pri-724 0 1
Dasatinib + PRT062607 Dasatinib PRT062607 0 0
Dasatinib + Ruxolitinib Dasatinib Ruxolitinib 0 2
Dasatinib + Saracatinib Dasatinib Saracatinib 0 0
Dasatinib + SCH772984 Dasatinib SCH772984 1 0
Dasatinib + Selumetinib Dasatinib Selumetinib 2 0
Dasatinib + Trametinib Dasatinib Trametinib 1 0
Dasatinib + Trastuzumab Dasatinib Trastuzumab 0 0
Dasatinib + Tretinoin Dasatinib Tretinoin 0 0
Dasatinib + Vandetanib Dasatinib Vandetanib 1 0
Dasatinib + Venetoclax Dasatinib Venetoclax 0 1
Dasatinib + Zileuton Dasatinib Zileuton 0 1


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