Drug Detail

Drug Name Dasatinib
Trade Name Sprycel
Synonyms BMS-354825
Drug Descriptions

Sprycel (dasatinib) is an inhibitor of the SRC-family of protein kinases, BCR-ABL, and ABL, and has additional activity against other kinases including KIT, DDR1/2, PDGFRA/B, and EPHA2, which prevents cell growth (PMID: 25709401, PMID: 25284748, PMID: 18797457). Sprycel (dasatinib) is FDA approved for both Philadelphia chromosome positive adult and pediatric chronic myelogenous leukemia and adult acute lymphoblastic leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 8 BCR-ABL Inhibitor 23 BTK inhibitor 20 CSF1R Inhibitor 22 DDR1 Inhibitor 8 DDR2 inhibitor 7 KIT Inhibitor 48 PDGFR Inhibitor (Pan) 27 SRC Inhibitor 26 TNK2 Inhibitor 6

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Therapy Name Therapy Description
Dasatinib + Cytarabine
Cytarabine + Dasatinib + Fludarabine + Idarubicin
Dasatinib + Afatinib
Abiraterone + Dasatinib
Dasatinib + lenalidomide
Dasatinib + Pri-724
Dasatinib + Trastuzumab
Dasatinib + Tretinoin
Cyclophosphamide + Dasatinib + Temsirolimus
Dasatinib + Erlotinib
Dasatinib + PRT062607
Dasatinib + Selumetinib
Bortezomib + Dasatinib + Dexamethasone + Doxorubicin + Palbociclib
Asciminib + Dasatinib
Dasatinib + Fulvestrant
Dasatinib + Osimertinib
Dasatinib + Gefitinib
Dasatinib + Decitabine
Cytarabine + Idarubicin + Dasatinib
BIRB-796 + Dasatinib
Cetuximab + Dasatinib + FOLFOX
Dasatinib + Pembrolizumab
Dasatinib + Paclitaxel + Carboplatin
Dasatinib + Lapatinib
Dasatinib + Ibrutinib + Prednisone
Crizotinib + Dasatinib
Gemcitabine + Dasatinib + Erlotinib
Dasatinib + SCH772984
Vandetanib + Dasatinib
Dasatinib + Saracatinib
Dasatinib + Ruxolitinib
Dasatinib + Nivolumab
Dasatinib + FOLFOX
BP1001 + Dasatinib
Cetuximab + Dasatinib
Zileuton + Dasatinib
Dasatinib + Venetoclax
Dasatinib + GSK343
Dasatinib + Ipilimumab
Bexarotene + Dasatinib
Dasatinib + ETC-1907206
Dasatinib + Dexamethasone + Ruxolitinib
Dasatinib Sprycel (dasatinib) is an inhibitor of the SRC-family of protein kinases, BCR-ABL, and ABL, and has additional activity against other kinases including KIT, DDR1/2, PDGFRA/B, and EPHA2, which prevents cell growth (PMID: 25709401, PMID: 25284748, PMID: 18797457). Sprycel (dasatinib) is FDA approved for both Philadelphia chromosome positive adult and pediatric chronic myelogenous leukemia and adult acute lymphoblastic leukemia (FDA.gov).
Dasatinib + Ganitumab
Dasatinib + Demcizumab
Dasatinib + Everolimus
Dasatinib + JQ1
Dasatinib + Rituximab + Fludarabine
Dasatinib + Trametinib
Asciminib + Dasatinib + Prednisone