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Drug Name Dasatinib
Trade Name Sprycel
Synonyms BMS-354825
Drug Descriptions

Sprycel (dasatinib) is an inhibitor of the SRC-family of protein kinases, BCR-ABL, and ABL, and has additional activity against other kinases including KIT, DDR1/2, PDGFRA/B, and EPHA2, which prevents cell growth (PMID: 25709401, PMID: 25284748, PMID: 18797457, PMID: 23942795). Sprycel (dasatinib) is FDA approved for both Philadelphia chromosome positive adult and pediatric chronic myelogenous leukemia and adult acute lymphoblastic leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 8 BCR-ABL Inhibitor 27 BTK inhibitor 26 CSF1R Inhibitor 26 DDR1 Inhibitor 8 DDR2 inhibitor 7 KIT Inhibitor 51 PDGFR Inhibitor (Pan) 27 SRC Inhibitor 30 TNK2 Inhibitor 6
CAS Registry Number 863127-77-9
NCIT ID C38713

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Dasatinib Abiraterone Dasatinib 0 1
Afatinib + Dasatinib Afatinib Dasatinib 0 1
Asciminib + Dasatinib Asciminib Dasatinib 0 2
Asciminib + Dasatinib + Prednisone Asciminib Dasatinib Prednisone 0 1
Asparaginase + Cyclophosphamide + Cytarabine + Dasatinib + Daunorubicin + Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dasatinib Daunorubicin Mercaptopurine Methotrexate Prednisone Vincristine Sulfate 0 1
Asparaginase + Cyclophosphamide + Cytarabine + Dasatinib + Dexamethasone + Doxorubicin + Methotrexate + Thioguanine + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dasatinib Dexamethasone Doxorubicin Methotrexate Thioguanine Vincristine Sulfate 0 1
Asparaginase + Dasatinib + Daunorubicin + Prednisone + Vincristine Sulfate Asparaginase Dasatinib Daunorubicin Prednisone Vincristine Sulfate 0 0
Bevacizumab + Dasatinib + Fluorouracil + Leucovorin + Oxaliplatin Bevacizumab Dasatinib Fluorouracil Leucovorin Oxaliplatin 0 1
Bexarotene + Dasatinib Bexarotene Dasatinib 0 0
BIRB-796 + Dasatinib BIRB-796 Dasatinib 0 0
Blinatumomab + Dasatinib Blinatumomab Dasatinib 0 1
Blinatumomab + Dasatinib + Dexamethasone Blinatumomab Dasatinib Dexamethasone 0 0
Blinatumomab + Dasatinib + Dexamethasone + Methotrexate Blinatumomab Dasatinib Dexamethasone Methotrexate 0 0
Blinatumomab + Dasatinib + Dexamethasone + Methotrexate + Prednisone Blinatumomab Dasatinib Dexamethasone Methotrexate Prednisone 0 1
Blinatumomab + Dasatinib + Dexamethasone + Prednisone Blinatumomab Dasatinib Dexamethasone Prednisone 0 1
Blinatumomab + Dasatinib + Methotrexate Blinatumomab Dasatinib Methotrexate 0 1
Bortezomib + Dasatinib + Dexamethasone + Doxorubicin + Palbociclib Bortezomib Dasatinib Dexamethasone Doxorubicin Palbociclib 0 1
BP1001 + Dasatinib BP1001 Dasatinib 0 1
Carboplatin + Dasatinib + Paclitaxel Carboplatin Dasatinib Paclitaxel 0 1
Cetuximab + Dasatinib Cetuximab Dasatinib 0 1
Cetuximab + Dasatinib + Fluorouracil + Leucovorin + Oxaliplatin Cetuximab Dasatinib Fluorouracil Leucovorin Oxaliplatin 0 0
Clofarabine + Cyclophosphamide + Dasatinib + Etoposide Clofarabine Cyclophosphamide Dasatinib Etoposide 0 0
CPI-0610 + Dasatinib CPI-0610 Dasatinib 0 0
CPI-0610 + Dasatinib + Rucaparib CPI-0610 Dasatinib Rucaparib 0 0
Crizotinib + Dasatinib Crizotinib Dasatinib 0 2
Cyclophosphamide + Cytarabine + Dasatinib + Dexamethasone + Doxorubicin + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Dasatinib Dexamethasone Doxorubicin Methotrexate Vincristine Sulfate 0 1
Cyclophosphamide + Dasatinib + Dexamethasone + Doxorubicin + Vincristine Sulfate Cyclophosphamide Dasatinib Dexamethasone Doxorubicin Vincristine Sulfate 0 1
Cyclophosphamide + Dasatinib + Temsirolimus Cyclophosphamide Dasatinib Temsirolimus 0 1
Cytarabine + Dasatinib Cytarabine Dasatinib 1 0
Cytarabine + Dasatinib + Fludarabine + Idarubicin Cytarabine Dasatinib Fludarabine Idarubicin 0 1
Cytarabine + Dasatinib + Idarubicin Cytarabine Dasatinib Idarubicin 0 1
Cytarabine + Dasatinib + Methotrexate Cytarabine Dasatinib Methotrexate 0 1
Dasatinib Dasatinib 37 50
Dasatinib + Decitabine Dasatinib Decitabine 0 1
Dasatinib + Decitabine and Cedazuridine Dasatinib Decitabine and Cedazuridine 0 1
Dasatinib + Demcizumab Dasatinib Demcizumab 0 0
Dasatinib + Dexamethasone Dasatinib Dexamethasone 0 0
Dasatinib + Dexamethasone + Hydrocortisone + Methotrexate Dasatinib Dexamethasone Hydrocortisone Methotrexate 0 0
Dasatinib + Dexamethasone + Imatinib Dasatinib Dexamethasone Imatinib 0 0
Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Methotrexate Dasatinib Dexamethasone Inotuzumab ozogamicin Methotrexate 0 1
Dasatinib + Dexamethasone + Inotuzumab ozogamicin + Methotrexate + Vincristine Sulfate Dasatinib Dexamethasone Inotuzumab ozogamicin Methotrexate Vincristine Sulfate 0 1
Dasatinib + Dexamethasone + Methotrexate Dasatinib Dexamethasone Methotrexate 0 1
Dasatinib + Dexamethasone + Ruxolitinib Dasatinib Dexamethasone Ruxolitinib 0 1
Dasatinib + Erlotinib Dasatinib Erlotinib 0 0
Dasatinib + Erlotinib + Gemcitabine Dasatinib Erlotinib Gemcitabine 0 1
Dasatinib + ETC-1907206 Dasatinib ETC-1907206 0 1
Dasatinib + Everolimus Dasatinib Everolimus 0 1
Dasatinib + Fludarabine + Rituximab Dasatinib Fludarabine Rituximab 0 1
Dasatinib + Fluorouracil + Leucovorin + Oxaliplatin Dasatinib Fluorouracil Leucovorin Oxaliplatin 0 0
Dasatinib + Fulvestrant Dasatinib Fulvestrant 0 0
Dasatinib + Ganitumab Dasatinib Ganitumab 0 1
Dasatinib + Gefitinib Dasatinib Gefitinib 0 0
Dasatinib + GSK343 Dasatinib GSK343 0 0
Dasatinib + Hydroxyurea Dasatinib Hydroxyurea 0 0
Dasatinib + Ibrutinib + Prednisone Dasatinib Ibrutinib Prednisone 0 1
Dasatinib + Inotuzumab ozogamicin + Methotrexate Dasatinib Inotuzumab ozogamicin Methotrexate 0 1
Dasatinib + Ipilimumab Dasatinib Ipilimumab 0 1
Dasatinib + Irinotecan + Nab-Rapamycin + Temozolomide Dasatinib Irinotecan Nab-Rapamycin Temozolomide 0 0
Dasatinib + Irinotecan + Sirolimus + Temozolomide Dasatinib Irinotecan Sirolimus Temozolomide 0 1
Dasatinib + JQ1 Dasatinib JQ1 0 0
Dasatinib + KRT-232 Dasatinib KRT-232 0 1
Dasatinib + KRT-232 + Nilotinib Dasatinib KRT-232 Nilotinib 0 0
Dasatinib + Lapatinib Dasatinib Lapatinib 0 0
Dasatinib + Lenalidomide Dasatinib Lenalidomide 0 1
Dasatinib + Mercaptopurine Dasatinib Mercaptopurine 0 0
Dasatinib + Methotrexate + Prednisone + Rituximab + Venetoclax Dasatinib Methotrexate Prednisone Rituximab Venetoclax 0 1
Dasatinib + Nivolumab Dasatinib Nivolumab 0 3
Dasatinib + Osimertinib Dasatinib Osimertinib 0 1
Dasatinib + Pembrolizumab Dasatinib Pembrolizumab 0 1
Dasatinib + Prednisone Dasatinib Prednisone 0 2
Dasatinib + PRI-724 Dasatinib PRI-724 0 1
Dasatinib + PRT062607 Dasatinib PRT062607 0 0
Dasatinib + RO7283420 + Tocilizumab Dasatinib RO7283420 Tocilizumab 0 1
Dasatinib + Rociletinib Dasatinib Rociletinib 0 0
Dasatinib + Rucaparib Dasatinib Rucaparib 0 0
Dasatinib + Ruxolitinib Dasatinib Ruxolitinib 0 2
Dasatinib + Saracatinib Dasatinib Saracatinib 0 0
Dasatinib + SCH772984 Dasatinib SCH772984 1 0
Dasatinib + Selumetinib Dasatinib Selumetinib 1 0
Dasatinib + Tamoxifen Dasatinib Tamoxifen 0 0
Dasatinib + Trametinib Dasatinib Trametinib 1 0
Dasatinib + Trastuzumab Dasatinib Trastuzumab 0 0
Dasatinib + Tretinoin Dasatinib Tretinoin 0 0
Dasatinib + Vandetanib Dasatinib Vandetanib 0 0
Dasatinib + Venetoclax Dasatinib Venetoclax 0 1
Dasatinib + Zileuton Dasatinib Zileuton 0 1


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