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Drug Name Demcizumab
Trade Name
Synonyms OMP-21M18|anti-delta-like 4 monoclonal antibody OMP-21M18
Drug Descriptions

Demcizumab (OMP-21M18) is a monoclonal antibody that binds DLL4 and prevents its interaction with Notch receptors, thereby inhibiting pathway activation and tumor growth (PMID: 19664991, PMID: 25324140, PMID: 32037195).

DrugClasses DLL4 Antibody 7
CAS Registry Number 1243262-17-0
NCIT ID C80041


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Demcizumab + Pemetrexed Disodium Carboplatin Demcizumab Pemetrexed Disodium 0 0
Dasatinib + Demcizumab Dasatinib Demcizumab 0 0
Demcizumab Demcizumab 0 2
Demcizumab + Gemcitabine Demcizumab Gemcitabine 0 0
Demcizumab + Gemcitabine + Nab-paclitaxel Demcizumab Gemcitabine Nab-paclitaxel 0 1
Demcizumab + Paclitaxel Demcizumab Paclitaxel 0 0
Demcizumab + Pembrolizumab Demcizumab Pembrolizumab 0 1

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