Drug Detail


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Drug Name GSK2126458
Trade Name
Synonyms GSK458|Omipalisib
Drug Descriptions

Omipalisib (GSK2126458) is a dual pan-PI3K and mTOR inhibitor, which blocks PI3K/AKT signaling to prevent cell proliferation (PMID: 24900173, PMID: 32382996).

DrugClasses mTOR Inhibitor 51 PI3K Inhibitor (Pan) 40
CAS Registry Number 1086062-66-9
NCIT ID C88270


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Dabrafenib + GSK2126458 Dabrafenib GSK2126458 6 0
Dasatinib + GSK2126458 Dasatinib GSK2126458 0 0
GSK2126458 GSK2126458 9 0
GSK2126458 + Lapatinib GSK2126458 Lapatinib 0 0
GSK2126458 + RXDX-105 GSK2126458 RXDX-105 1 0
GSK2126458 + Trametinib GSK2126458 Trametinib 7 0

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