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Drug Name Lapatinib
Trade Name Tykerb
Synonyms Lapatinib Ditosylate
Drug Descriptions

Tykerb (lapatinib) reversibly inhibits ERBB2 (HER2) and EGFR, resulting in decreased downstream signaling and potentially leading to reduced tumor growth (PMID: 22477724). Tykerb (lapatinib) is FDA approved for ERBB2 (HER2)-positive (overexpressing) breast cancer (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 61 HER2 Inhibitor 41
CAS Registry Number 388082-78-8
NCIT ID C66878

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Lapatinib + WEHI-539 A-1210477 Lapatinib WEHI-539 0 0
A3 + Lapatinib A3 Lapatinib 0 0
Abemaciclib + Lapatinib Abemaciclib Lapatinib 0 0
Ado-trastuzumab emtansine + Lapatinib Ado-trastuzumab emtansine Lapatinib 0 1
Ado-trastuzumab emtansine + Lapatinib + Nab-paclitaxel Ado-trastuzumab emtansine Lapatinib Nab-paclitaxel 0 1
Alpelisib + Fulvestrant + Lapatinib Alpelisib Fulvestrant Lapatinib 0 0
Anastrozole + Lapatinib Anastrozole Lapatinib 0 0
Anastrozole + Lapatinib + Trastuzumab Anastrozole Lapatinib Trastuzumab 0 0
AZD4547 + Lapatinib AZD4547 Lapatinib 0 0
Bortezomib + Lapatinib Bortezomib Lapatinib 0 1
Buparlisib + Capecitabine + Lapatinib Buparlisib Capecitabine Lapatinib 0 1
Buparlisib + Lapatinib + Trastuzumab Buparlisib Lapatinib Trastuzumab 0 0
Cabazitaxel + Lapatinib Cabazitaxel Lapatinib 0 1
Capecitabine + Cisplatin + Docetaxel + Lapatinib + Trastuzumab + Vinorelbine Capecitabine Cisplatin Docetaxel Lapatinib Trastuzumab Vinorelbine 0 0
Capecitabine + Cyclophosphamide + Lapatinib + Trastuzumab Capecitabine Cyclophosphamide Lapatinib Trastuzumab 0 1
Capecitabine + Everolimus + Lapatinib Capecitabine Everolimus Lapatinib 0 1
Capecitabine + Lapatinib Capecitabine Lapatinib 0 5
Capecitabine + Lapatinib + Oxaliplatin Capecitabine Lapatinib Oxaliplatin 0 1
Capivasertib + Fulvestrant + Lapatinib Capivasertib Fulvestrant Lapatinib 0 0
Capmatinib + Lapatinib Capmatinib Lapatinib 0 0
Carboplatin + Cisplatin + Lapatinib + Paclitaxel Carboplatin Cisplatin Lapatinib Paclitaxel 0 1
Carboplatin + Lapatinib + Paclitaxel Carboplatin Lapatinib Paclitaxel 0 1
Cetuximab + Lapatinib Cetuximab Lapatinib 0 0
Cisplatin + Lapatinib Cisplatin Lapatinib 0 0
Cisplatin + Lapatinib + Radiotherapy Cisplatin Lapatinib Radiotherapy 0 1
CPI-455 + Lapatinib CPI-455 Lapatinib 0 0
Crizotinib + Lapatinib Crizotinib Lapatinib 0 0
Crizotinib + Lapatinib + Linsitinib Crizotinib Lapatinib Linsitinib 0 0
Dabrafenib + Lapatinib Dabrafenib Lapatinib 0 1
Dasatinib + Lapatinib Dasatinib Lapatinib 0 0
Docetaxel + Lapatinib Docetaxel Lapatinib 0 1
Docetaxel + Lapatinib + Trastuzumab Docetaxel Lapatinib Trastuzumab 0 0
Entinostat + Lapatinib Entinostat Lapatinib 0 0
Entinostat + Lapatinib + Trastuzumab Entinostat Lapatinib Trastuzumab 0 1
Everolimus + Lapatinib Everolimus Lapatinib 0 1
Exemestane + Lapatinib Exemestane Lapatinib 0 0
Exemestane + Lapatinib + Trastuzumab Exemestane Lapatinib Trastuzumab 0 0
Fluorouracil + Irinotecan + Lapatinib + Leucovorin Fluorouracil Irinotecan Lapatinib Leucovorin 0 1
Fluorouracil + Lapatinib + Leucovorin + Oxaliplatin Fluorouracil Lapatinib Leucovorin Oxaliplatin 0 1
Fulvestrant + Ipatasertib + Lapatinib Fulvestrant Ipatasertib Lapatinib 0 0
Fulvestrant + Lapatinib Fulvestrant Lapatinib 0 0
Fulvestrant + Lapatinib + Sirolimus Fulvestrant Lapatinib Sirolimus 0 0
Futibatinib + Lapatinib Futibatinib Lapatinib 0 0
Gemcitabine + Lapatinib Gemcitabine Lapatinib 0 1
GSK2126458 + Lapatinib GSK2126458 Lapatinib 0 0
GSK690693 + Lapatinib GSK690693 Lapatinib 0 0
Idelalisib + Lapatinib Idelalisib Lapatinib 0 0
Inavolisib + Lapatinib Inavolisib Lapatinib 0 0
Infigratinib + Lapatinib Infigratinib Lapatinib 0 0
Lapatinib Lapatinib 7 15
Lapatinib + Letrozole Lapatinib Letrozole 0 1
Lapatinib + Letrozole + Trastuzumab Lapatinib Letrozole Trastuzumab 0 0
Lapatinib + Metformin Lapatinib Metformin 0 1
Lapatinib + MK2206 Lapatinib MK2206 0 0
Lapatinib + MRTX-1133 Lapatinib MRTX-1133 0 0
Lapatinib + Paclitaxel Lapatinib Paclitaxel 0 3
Lapatinib + Paclitaxel + Trastuzumab Lapatinib Paclitaxel Trastuzumab 1 0
Lapatinib + Palbociclib Lapatinib Palbociclib 0 0
Lapatinib + Panobinostat Lapatinib Panobinostat 1 0
Lapatinib + Patritumab Lapatinib Patritumab 0 0
Lapatinib + Perifosine Lapatinib Perifosine 0 0
Lapatinib + Pertuzumab Lapatinib Pertuzumab 0 0
Lapatinib + Pictilisib Lapatinib Pictilisib 0 0
Lapatinib + RU-SKI 43 Lapatinib RU-SKI 43 0 0
Lapatinib + S63845 Lapatinib S63845 0 0
Lapatinib + Saracatinib Lapatinib Saracatinib 0 0
Lapatinib + SCH772984 Lapatinib SCH772984 0 0
Lapatinib + Selumetinib Lapatinib Selumetinib 0 0
Lapatinib + SHP099 Lapatinib SHP099 0 0
Lapatinib + Sirolimus Lapatinib Sirolimus 0 1
Lapatinib + Tamoxifen Lapatinib Tamoxifen 0 0
Lapatinib + Temozolomide Lapatinib Temozolomide 0 1
Lapatinib + Torkinib Lapatinib Torkinib 0 0
Lapatinib + Trametinib Lapatinib Trametinib 0 0
Lapatinib + Trastuzumab Lapatinib Trastuzumab 0 7
Lapatinib + Veliparib Lapatinib Veliparib 0 1
Lapatinib + Vemurafenib Lapatinib Vemurafenib 1 0
Lapatinib + Vorinostat Lapatinib Vorinostat 0 1


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