Drug Detail

Drug Name Lapatinib
Trade Name Tykerb
Synonyms FMM
Drug Descriptions

Tykerb (lapatinib) reversibly inhibits ERBB2 (HER2) and EGFR, resulting in decreased downstream signaling and potentially leading to reduced tumor growth (PMID: 22477724). Tykerb (lapatinib) is FDA approved for ERBB2 (HER2)-positive (overexpressing) breast cancer (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 43 HER2 (ERBB2) Antibody 29

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Lapatinib + WEHI-539 A-1210477 Lapatinib WEHI-539 0 0
A3 + Lapatinib A3 Lapatinib 0 0
Abemaciclib + Lapatinib Abemaciclib Lapatinib 1 0
Ado-trastuzumab emtansine + Lapatinib Ado-trastuzumab emtansine Lapatinib 0 1
Ado-trastuzumab emtansine + Lapatinib + Nab-paclitaxel Ado-trastuzumab emtansine Lapatinib Nab-paclitaxel 0 1
Anastrozole + Lapatinib Anastrozole Lapatinib 0 0
Anastrozole + Lapatinib + Trastuzumab Anastrozole Lapatinib Trastuzumab 0 0
AZD4547 + Lapatinib AZD4547 Lapatinib 1 0
Bortezomib + Lapatinib Bortezomib Lapatinib 0 1
Buparlisib + Capecitabine + Lapatinib Buparlisib Capecitabine Lapatinib 0 1
Buparlisib + Lapatinib + Trastuzumab Buparlisib Lapatinib Trastuzumab 1 0
Cabazitaxel + Lapatinib Cabazitaxel Lapatinib 0 1
Capecitabine + Cyclophosphamide + Lapatinib + Trastuzumab Capecitabine Cyclophosphamide Lapatinib Trastuzumab 0 1
Capecitabine + Everolimus + Lapatinib Capecitabine Everolimus Lapatinib 0 1
Capecitabine + Lapatinib Capecitabine Lapatinib 4 4
Capecitabine + Lapatinib + Oxaliplatin Capecitabine Lapatinib Oxaliplatin 2 1
Carboplatin + Cisplatin + Lapatinib + Paclitaxel Carboplatin Cisplatin Lapatinib Paclitaxel 0 1
Carboplatin + Lapatinib + Paclitaxel Carboplatin Lapatinib Paclitaxel 0 1
Cetuximab + Lapatinib Cetuximab Lapatinib 2 0
Cisplatin + Lapatinib Cisplatin Lapatinib 0 1
CPI-455 + Lapatinib CPI-455 Lapatinib 1 0
Crizotinib + Lapatinib Crizotinib Lapatinib 4 0
Crizotinib + Lapatinib + Linsitinib Crizotinib Lapatinib Linsitinib 0 0
Dabrafenib + Lapatinib Dabrafenib Lapatinib 0 1
Dasatinib + Lapatinib Dasatinib Lapatinib 0 0
Docetaxel + Lapatinib Docetaxel Lapatinib 0 1
Docetaxel + Lapatinib + Trastuzumab Docetaxel Lapatinib Trastuzumab 0 0
Entinostat + Lapatinib Entinostat Lapatinib 1 0
Entinostat + Lapatinib + Trastuzumab Entinostat Lapatinib Trastuzumab 1 1
Everolimus + Lapatinib Everolimus Lapatinib 0 1
Exemestane + Lapatinib Exemestane Lapatinib 0 0
Exemestane + Lapatinib + Trastuzumab Exemestane Lapatinib Trastuzumab 0 0
Fluorouracil + Irinotecan + Lapatinib + Leucovorin Fluorouracil Irinotecan Lapatinib Leucovorin 0 1
Fluorouracil + Lapatinib + Leucovorin + Oxaliplatin Fluorouracil Lapatinib Leucovorin Oxaliplatin 0 1
Fulvestrant + Lapatinib Fulvestrant Lapatinib 0 0
Gemcitabine + Lapatinib Gemcitabine Lapatinib 0 1
GSK2126458 + Lapatinib GSK2126458 Lapatinib 0 0
Lapatinib Lapatinib 85 14
Lapatinib + Letrozole Lapatinib Letrozole 0 1
Lapatinib + Letrozole + Trastuzumab Lapatinib Letrozole Trastuzumab 0 0
Lapatinib + Metformin Lapatinib Metformin 0 1
Lapatinib + MK2206 Lapatinib MK2206 2 0
Lapatinib + Paclitaxel Lapatinib Paclitaxel 1 1
Lapatinib + Paclitaxel + Trastuzumab Lapatinib Paclitaxel Trastuzumab 1 0
Lapatinib + Palbociclib Lapatinib Palbociclib 1 0
Lapatinib + Panobinostat Lapatinib Panobinostat 1 0
Lapatinib + Patritumab Lapatinib Patritumab 0 0
Lapatinib + Pertuzumab Lapatinib Pertuzumab 1 0
Lapatinib + RU-SKI 43 Lapatinib RU-SKI 43 0 0
Lapatinib + S63845 Lapatinib S63845 2 0
Lapatinib + Saracatinib Lapatinib Saracatinib 1 0
Lapatinib + SCH772984 Lapatinib SCH772984 0 0
Lapatinib + Sirolimus Lapatinib Sirolimus 0 1
Lapatinib + Temozolomide Lapatinib Temozolomide 0 1
Lapatinib + Torkinib Lapatinib Torkinib 1 0
Lapatinib + Trametinib Lapatinib Trametinib 0 0
Lapatinib + Trastuzumab Lapatinib Trastuzumab 15 7
Lapatinib + Veliparib Lapatinib Veliparib 0 1
Lapatinib + Vemurafenib Lapatinib Vemurafenib 1 0


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