Drug Detail


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Drug Name MRTX-1133
Trade Name
Synonyms MRTX1133|MRTX 1133
Drug Descriptions

MRTX-1133 selectively inhibits KRAS G12D, which results in decreased downstream signaling and potentially leads to reduced tumor growth (PMID: 34889605).

DrugClasses KRAS G12D Inhibitor 12
CAS Registry Number NA


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + MRTX-1133 Afatinib MRTX-1133 0 0
Alpelisib + MRTX-1133 Alpelisib MRTX-1133 0 0
BTX-6654 + MRTX-1133 BTX-6654 MRTX-1133 0 0
BTX-7312 + MRTX-1133 BTX-7312 MRTX-1133 0 0
Canertinib + MRTX-1133 Canertinib MRTX-1133 0 0
Cetuximab + MRTX-1133 Cetuximab MRTX-1133 0 0
Erlotinib + MRTX-1133 Erlotinib MRTX-1133 0 0
IAG933 + MRTX-1133 IAG933 MRTX-1133 0 0
KO-2806 + MRTX-1133 KO-2806 MRTX-1133 0 0
Lapatinib + MRTX-1133 Lapatinib MRTX-1133 0 0
MRTX-1133 MRTX-1133 5 1
MRTX-1133 + MRTX1719 MRTX-1133 MRTX1719 0 0
MRTX-1133 + Neratinib MRTX-1133 Neratinib 0 0
MRTX-1133 + Trametinib MRTX-1133 Trametinib 0 0
MRTX-1133 + Ulixertinib MRTX-1133 Ulixertinib 0 0

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