Drug Detail

Drug Name Alpelisib
Trade Name Piqray
Synonyms BYL719
Drug Descriptions

Piqray (Alpelisib) is a selective PIK3CA inhibitor that blocks activation of the PI3K signaling pathway and inhibits tumor growth (PMID: 23726034). Piqray (Alpelisib) is FDA approved in combination with fulvestrant for use in postmenopausal women, and men, with advanced or metastatic hormone receptor (HR)-positive, ERBB2 (HER2)-negative, PIK3CA-mutant breast cancer (FDA.gov).

DrugClasses PIK3CA inhibitor 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ado-trastuzumab emtansine + Alpelisib Ado-trastuzumab emtansine Alpelisib 0 1
AEB071 + Alpelisib AEB071 Alpelisib 0 1
Alpelisib Alpelisib 32 6
Alpelisib + AZD1208 AZD1208 Alpelisib 0 0
Alpelisib + AZD6482 AZD6482 Alpelisib 2 0
Alpelisib + AZD6482 + Binimetinib AZD6482 Alpelisib Binimetinib 1 0
Alpelisib + AZD6482 + Binimetinib + Encorafenib AZD6482 Alpelisib Binimetinib Encorafenib 1 0
Alpelisib + AZD6482 + Encorafenib AZD6482 Alpelisib Encorafenib 1 0
Alpelisib + AZD8186 AZD8186 Alpelisib 1 0
Alpelisib + AZD8186 + Enzalutamide AZD8186 Alpelisib Enzalutamide 1 0
Alpelisib + BGJ398 Alpelisib BGJ398 3 1
Alpelisib + Binimetinib Alpelisib Binimetinib 6 1
Alpelisib + Capecitabine Alpelisib Capecitabine 0 2
Alpelisib + Cetuximab Alpelisib Cetuximab 0 2
Alpelisib + Cetuximab + Encorafenib Alpelisib Cetuximab Encorafenib 6 1
Alpelisib + CGM097 + Navitoclax + Trametinib Alpelisib CGM097 Navitoclax Trametinib 0 0
Alpelisib + Cisplatin Alpelisib Cisplatin 0 1
Alpelisib + Crizotinib Alpelisib Crizotinib 0 0
Alpelisib + Dabrafenib + Erlotinib + Navitoclax Alpelisib Dabrafenib Erlotinib Navitoclax 1 0
Alpelisib + Encorafenib Alpelisib Encorafenib 1 0
Alpelisib + Encorafenib + GSK2636771 Alpelisib Encorafenib GSK2636771 1 0
Alpelisib + Enzalutamide Alpelisib Enzalutamide 0 1
Alpelisib + Erlotinib + Navitoclax + Trametinib Alpelisib Erlotinib Navitoclax Trametinib 0 0
Alpelisib + Everolimus Alpelisib Everolimus 0 1
Alpelisib + Everolimus + Exemestane Alpelisib Everolimus Exemestane 0 1
Alpelisib + Exemestane Alpelisib Exemestane 0 1
Alpelisib + Fulvestrant Alpelisib Fulvestrant 13 2
Alpelisib + Fulvestrant + Ribociclib Alpelisib Fulvestrant Ribociclib 0 1
Alpelisib + Ganitumab Alpelisib Ganitumab 0 1
Alpelisib + Gemcitabine + Nab-paclitaxel Alpelisib Gemcitabine Nab-paclitaxel 0 1
Alpelisib + GSK2334470 Alpelisib GSK2334470 1 0
Alpelisib + GSK2636771 Alpelisib GSK2636771 1 0
Alpelisib + Letrozole Alpelisib Letrozole 2 5
Alpelisib + Letrozole + Ribociclib Alpelisib Letrozole Ribociclib 0 1
Alpelisib + LGH447 Alpelisib LGH447 0 1
Alpelisib + LJM716 Alpelisib LJM716 0 1
Alpelisib + LJM716 + Trastuzumab Alpelisib LJM716 Trastuzumab 0 1
Alpelisib + LSZ 102 Alpelisib LSZ 102 0 1
Alpelisib + Lucitanib Alpelisib Lucitanib 1 0
Alpelisib + Nab-paclitaxel Alpelisib Nab-paclitaxel 0 1
Alpelisib + NVP-AEW541 Alpelisib NVP-AEW541 1 0
Alpelisib + Olaparib Alpelisib Olaparib 1 1
Alpelisib + Paclitaxel Alpelisib Paclitaxel 0 1
Alpelisib + PLX4720 Alpelisib PLX4720 1 0
Alpelisib + Ribociclib Alpelisib Ribociclib 0 0
Alpelisib + WEHI-539 Alpelisib WEHI-539 1 0


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