Drug Detail


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Drug Name Ganitumab
Trade Name
Synonyms AMG-479
Drug Descriptions

Ganitumab (AMG-479) is a recombinant antibody that binds to and inhibits IGF-1R. Inhibition of IGF-1R prevents activation of the downstream PI3K/Akt pathway, which may inhibit proliferation and induce apoptosis of tumor cells (NCI Drug Dictionary).

DrugClasses IGF-1R Inhibitor 17
CAS Registry Number 905703-97-1
NCIT ID C71531


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + Ganitumab Alpelisib Ganitumab 0 1
Binimetinib + Ganitumab Binimetinib Ganitumab 0 1
Conatumumab + Ganitumab Conatumumab Ganitumab 0 0
Cyclophosphamide + Doxorubicin + Etoposide + Ganitumab + Ifosfamide + Vincristine Sulfate Cyclophosphamide Doxorubicin Etoposide Ganitumab Ifosfamide Vincristine Sulfate 0 0
Dasatinib + Ganitumab Dasatinib Ganitumab 0 1
Everolimus + Ganitumab Everolimus Ganitumab 0 1
Everolimus + Ganitumab + Panitumumab Everolimus Ganitumab Panitumumab 0 1
Ganitumab Ganitumab 0 3
Ganitumab + Palbociclib Ganitumab Palbociclib 0 1
Ganitumab + Trametinib Ganitumab Trametinib 7 0

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