Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Ganitumab
Trade Name
Synonyms AMG-479
Drug Descriptions

Ganitumab (AMG-479) is a recombinant antibody that binds to and inhibits IGF-1R. Inhibition of IGF-1R prevents activation of the downstream PI3K/Akt pathway, which may inhibit proliferation and induce apoptosis of tumor cells (NCI Drug Dictionary).

DrugClasses IGF-1R Inhibitor 17
CAS Registry Number 905703-97-1
NCIT ID C71531


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Alpelisib + Ganitumab Alpelisib Ganitumab 0 1
Binimetinib + Ganitumab Binimetinib Ganitumab 0 1
Conatumumab + Ganitumab Conatumumab Ganitumab 0 0
Dasatinib + Ganitumab Dasatinib Ganitumab 0 1
Everolimus + Ganitumab Everolimus Ganitumab 0 1
Everolimus + Ganitumab + Panitumumab Everolimus Ganitumab Panitumumab 0 1
Ganitumab Ganitumab 0 3
Ganitumab + Palbociclib Ganitumab Palbociclib 0 1
Ganitumab + Trametinib Ganitumab Trametinib 7 0

Additional content available in CKB BOOST