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Therapy Name | Conatumumab + Ganitumab |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Conatumumab | AMG 655|AMG-655|AMG655 | Conatumumab (AMG 655) is a monoclonal antibody that binds to and activates the TRAIL receptor 2 (TR-2), initiating caspase activation and inducing tumor cell apoptosis (PMID: 24816908). | ||
Ganitumab | AMG-479 | IGF-1R Inhibitor 17 | Ganitumab (AMG-479) is a recombinant antibody that binds to and inhibits IGF-1R. Inhibition of IGF-1R prevents activation of the downstream PI3K/Akt pathway, which may inhibit proliferation and induce apoptosis of tumor cells (NCI Drug Dictionary). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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