Drug Detail

Drug Name Everolimus
Trade Name Afinitor
Synonyms RAD001|Zortress
Drug Descriptions

Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov).

DrugClasses mTORC1 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Everolimus Abemaciclib Everolimus 1 0
Abemaciclib + Everolimus + Exemestane Abemaciclib Everolimus Exemestane 0 1
Adavosertib + Everolimus Adavosertib Everolimus 1 0
AEB071 + Everolimus AEB071 Everolimus 2 1
Alpelisib + Everolimus Alpelisib Everolimus 0 1
Alpelisib + Everolimus + Exemestane Alpelisib Everolimus Exemestane 0 1
Anakinra + Everolimus Anakinra Everolimus 0 1
Anastrozole + Everolimus Anastrozole Everolimus 0 1
Anastrozole + Everolimus + Fulvestrant Anastrozole Everolimus Fulvestrant 0 1
Apalutamide + Everolimus Apalutamide Everolimus 0 1
BDA-366 + Everolimus BDA-366 Everolimus 0 0
Bendamustine + Everolimus Bendamustine Everolimus 0 1
Bevacizumab + Doxorubicin + Everolimus Bevacizumab Doxorubicin Everolimus 0 0
Bevacizumab + Everolimus Bevacizumab Everolimus 7 4
BEZ235 + Everolimus BEZ235 Everolimus 2 1
Bicalutamide + Everolimus Bicalutamide Everolimus 1 0
Binimetinib + Everolimus Binimetinib Everolimus 4 0
Bortezomib + Everolimus Bortezomib Everolimus 0 1
Buparlisib + Everolimus Buparlisib Everolimus 1 1
Capecitabine + Everolimus + Lapatinib Capecitabine Everolimus Lapatinib 0 1
Carboplatin + Cetuximab + Everolimus + Paclitaxel Carboplatin Cetuximab Everolimus Paclitaxel 0 1
Carboplatin + Everolimus + Pegylated liposomal-doxorubicin Carboplatin Everolimus Pegylated liposomal-doxorubicin 0 1
Carotuximab + Everolimus + Letrozole Carotuximab Everolimus Letrozole 0 1
CB-839 + Everolimus CB-839 Everolimus 1 2
Ceritinib + Everolimus Ceritinib Everolimus 0 1
CH5132799 + Everolimus CH5132799 Everolimus 0 0
Cisplatin + Everolimus + Gemcitabine Cisplatin Everolimus Gemcitabine 0 1
Cisplatin + Everolimus + Paclitaxel Cisplatin Everolimus Paclitaxel 1 0
Cixutumumab + Everolimus + Octreotide acetate Cixutumumab Everolimus Octreotide acetate 1 0
Cyclophosphamide + Etoposide + Everolimus + Nelarabine Cyclophosphamide Etoposide Everolimus Nelarabine 0 1
Cyclophosphamide + Everolimus Cyclophosphamide Everolimus 0 0
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 0 0
Dasatinib + Everolimus Dasatinib Everolimus 0 1
Denosumab + Everolimus Denosumab Everolimus 0 1
Dexamethasone + Everolimus Dexamethasone Everolimus 0 0
Dexamethasone + Everolimus + Pomalidomide Dexamethasone Everolimus Pomalidomide 0 1
Dexamethasone + Everolimus + Ribociclib Dexamethasone Everolimus Ribociclib 0 1
Docetaxel + Everolimus Docetaxel Everolimus 1 0
DTRMWXHS-12 + Everolimus DTRMWXHS-12 Everolimus 0 1
DTRMWXHS-12 + Everolimus + Pomalidomide DTRMWXHS-12 Everolimus Pomalidomide 0 1
Enzalutamide + Everolimus Enzalutamide Everolimus 0 1
Eribulin + Everolimus Eribulin Everolimus 0 1
Erlotinib + Everolimus Erlotinib Everolimus 1 0
Etoposide + Everolimus Etoposide Everolimus 0 0
Everolimus Everolimus 38 59
Everolimus + Exemestane Everolimus Exemestane 1 5
Everolimus + Exemestane + Palbociclib Everolimus Exemestane Palbociclib 0 1
Everolimus + Exemestane + Ribociclib Everolimus Exemestane Ribociclib 0 2
Everolimus + Exemestane + Xentuzumab Everolimus Exemestane Xentuzumab 0 1
Everolimus + Fosbretabulin Everolimus Fosbretabulin 0 1
Everolimus + Fulvestrant Everolimus Fulvestrant 0 3
Everolimus + Fulvestrant + Neratinib Everolimus Fulvestrant Neratinib 0 0
Everolimus + Ganitumab Everolimus Ganitumab 0 1
Everolimus + Ganitumab + Panitumumab Everolimus Ganitumab Panitumumab 0 1
Everolimus + Gemcitabine Everolimus Gemcitabine 0 1
Everolimus + H3B-5942 Everolimus H3B-5942 0 0
Everolimus + Hydroxychloroquine Everolimus Hydroxychloroquine 1 2
Everolimus + Ibrutinib Everolimus Ibrutinib 0 1
Everolimus + Imatinib Everolimus Imatinib 0 1
Everolimus + Itacitinib Everolimus Itacitinib 0 1
Everolimus + IWR-1 Everolimus IWR-1 0 0
Everolimus + Lapatinib Everolimus Lapatinib 0 1
Everolimus + Lenvatinib Everolimus Lenvatinib 2 7
Everolimus + Letrozole Everolimus Letrozole 0 5
Everolimus + Letrozole + Metformin Everolimus Letrozole Metformin 1 0
Everolimus + Letrozole + Ribociclib Everolimus Letrozole Ribociclib 0 1
Everolimus + Letrozole + Trastuzumab Everolimus Letrozole Trastuzumab 0 1
Everolimus + Metformin Everolimus Metformin 1 0
Everolimus + MM-141 Everolimus MM-141 0 1
Everolimus + Nelarabine Everolimus Nelarabine 0 0
Everolimus + Neratinib Everolimus Neratinib 0 1
Everolimus + Niraparib Everolimus Niraparib 0 1
Everolimus + Octreotide Everolimus Octreotide 1 0
Everolimus + Octreotide acetate Everolimus Octreotide acetate 0 1
Everolimus + Olaparib Everolimus Olaparib 1 0
Everolimus + Paclitaxel Everolimus Paclitaxel 0 0
Everolimus + Palbociclib Everolimus Palbociclib 1 0
Everolimus + Panobinostat Everolimus Panobinostat 0 4
Everolimus + Pasireotide Everolimus Pasireotide 1 2
Everolimus + Pazopanib Everolimus Pazopanib 1 1
Everolimus + Pimasertib Everolimus Pimasertib 4 0
Everolimus + PLX4720 Everolimus PLX4720 1 0
Everolimus + Radiotherapy Everolimus Radiotherapy 1 0
Everolimus + Ribociclib Everolimus Ribociclib 2 6
Everolimus + RX-0201 Everolimus RX-0201 1 1
Everolimus + SCH772984 Everolimus SCH772984 1 0
Everolimus + Selumetinib Everolimus Selumetinib 4 0
Everolimus + Sonidegib Everolimus Sonidegib 0 1
Everolimus + Sorafenib Everolimus Sorafenib 0 2
Everolimus + Spartalizumab Everolimus Spartalizumab 0 1
Everolimus + Sunitinib Everolimus Sunitinib 1 0
Everolimus + Tacrolimus Everolimus Tacrolimus 0 0
Everolimus + Talazoparib Everolimus Talazoparib 1 0
Everolimus + Tamoxifen Everolimus Tamoxifen 1 1
Everolimus + Toremifene Everolimus Toremifene 0 1
Everolimus + Trametinib Everolimus Trametinib 0 1
Everolimus + Trastuzumab Everolimus Trastuzumab 0 0
Everolimus + Trastuzumab + Vinorelbine Everolimus Trastuzumab Vinorelbine 1 1
Everolimus + U0126 Everolimus U0126 0 0
Everolimus + Vandetanib Everolimus Vandetanib 2 1
Everolimus + Vemurafenib Everolimus Vemurafenib 0 1
Everolimus + Vorolanib Everolimus Vorolanib 4 1
Everolimus + XAV939 Everolimus XAV939 0 0