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Drug Name Everolimus
Trade Name Afinitor
Synonyms RAD001|Zortress
Drug Descriptions

Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov).

DrugClasses mTORC1 Inhibitor 9
CAS Registry Number 159351-69-6
NCIT ID C48387

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Everolimus Abemaciclib Everolimus 0 0
Abemaciclib + Everolimus + Exemestane Abemaciclib Everolimus Exemestane 0 1
Adagrasib + Everolimus Adagrasib Everolimus 0 0
Adavosertib + Everolimus Adavosertib Everolimus 0 0
Ado-trastuzumab emtansine + Everolimus Ado-trastuzumab emtansine Everolimus 0 0
Alpelisib + Everolimus Alpelisib Everolimus 4 1
Alpelisib + Everolimus + Exemestane Alpelisib Everolimus Exemestane 0 1
Amcenestrant + Everolimus Amcenestrant Everolimus 0 1
Anakinra + Everolimus Anakinra Everolimus 0 1
Anastrozole + Everolimus Anastrozole Everolimus 0 1
Anastrozole + Everolimus + Fulvestrant Anastrozole Everolimus Fulvestrant 0 1
Apalutamide + Everolimus Apalutamide Everolimus 0 1
ARS1620 + Everolimus ARS1620 Everolimus 0 0
ARS1620 + Everolimus + Linsitinib ARS1620 Everolimus Linsitinib 0 0
BDA-366 + Everolimus BDA-366 Everolimus 0 0
Bendamustine + Everolimus Bendamustine Everolimus 0 1
Bevacizumab + Carboplatin + Everolimus + Paclitaxel Bevacizumab Carboplatin Everolimus Paclitaxel 0 1
Bevacizumab + Doxorubicin + Everolimus Bevacizumab Doxorubicin Everolimus 1 0
Bevacizumab + Everolimus Bevacizumab Everolimus 1 4
Bicalutamide + Everolimus Bicalutamide Everolimus 0 0
Binimetinib + Everolimus Binimetinib Everolimus 4 0
BMS-754807 + Everolimus BMS-754807 Everolimus 0 0
Bortezomib + Everolimus Bortezomib Everolimus 0 1
Buparlisib + Everolimus Buparlisib Everolimus 0 1
Camizestrant + Everolimus Camizestrant Everolimus 0 1
Capecitabine + Everolimus + Lapatinib Capecitabine Everolimus Lapatinib 0 1
Carboplatin + Cetuximab + Everolimus + Paclitaxel Carboplatin Cetuximab Everolimus Paclitaxel 0 1
Carboplatin + Everolimus + Pegylated liposomal doxorubicin Carboplatin Everolimus Pegylated liposomal doxorubicin 0 1
Carboplatin + Everolimus + Trastuzumab Carboplatin Everolimus Trastuzumab 0 0
Carotuximab + Everolimus + Letrozole Carotuximab Everolimus Letrozole 0 1
Cemiplimab + Everolimus + Prednisone Cemiplimab Everolimus Prednisone 0 1
Ceritinib + Everolimus Ceritinib Everolimus 0 1
Cisplatin + Everolimus + Gemcitabine Cisplatin Everolimus Gemcitabine 0 1
Cisplatin + Everolimus + Paclitaxel Cisplatin Everolimus Paclitaxel 0 0
Cixutumumab + Everolimus + Octreotide acetate Cixutumumab Everolimus Octreotide acetate 0 0
Cyclophosphamide + Etoposide + Everolimus + Nelarabine Cyclophosphamide Etoposide Everolimus Nelarabine 0 1
Cyclophosphamide + Everolimus Cyclophosphamide Everolimus 0 0
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 1 0
Dactolisib + Everolimus Dactolisib Everolimus 0 1
Dasatinib + Everolimus Dasatinib Everolimus 0 1
Denosumab + Everolimus Denosumab Everolimus 0 1
Dexamethasone + Everolimus Dexamethasone Everolimus 0 0
Dexamethasone + Everolimus + Pomalidomide Dexamethasone Everolimus Pomalidomide 0 1
Dexamethasone + Everolimus + Ribociclib Dexamethasone Everolimus Ribociclib 0 1
DFF332 + Everolimus DFF332 Everolimus 0 1
Docetaxel + Everolimus Docetaxel Everolimus 0 0
DTRMWXHS-12 + Everolimus DTRMWXHS-12 Everolimus 0 1
DTRMWXHS-12 + Everolimus + Pomalidomide DTRMWXHS-12 Everolimus Pomalidomide 0 2
Elacestrant + Everolimus Elacestrant Everolimus 0 1
Enzalutamide + Everolimus Enzalutamide Everolimus 0 1
Eribulin + Everolimus Eribulin Everolimus 0 1
Erlotinib + Everolimus Erlotinib Everolimus 0 0
Etoposide + Everolimus Etoposide Everolimus 0 0
Everolimus Everolimus 47 73
Everolimus + Exemestane Everolimus Exemestane 1 10
Everolimus + Exemestane + Palbociclib Everolimus Exemestane Palbociclib 0 1
Everolimus + Exemestane + Ribociclib Everolimus Exemestane Ribociclib 0 2
Everolimus + Exemestane + Trastuzumab Everolimus Exemestane Trastuzumab 0 0
Everolimus + Exemestane + Xentuzumab Everolimus Exemestane Xentuzumab 0 1
Everolimus + Fosbretabulin Everolimus Fosbretabulin 0 1
Everolimus + FRAX1036 Everolimus FRAX1036 0 0
Everolimus + Fulvestrant Everolimus Fulvestrant 0 6
Everolimus + Fulvestrant + Neratinib Everolimus Fulvestrant Neratinib 0 0
Everolimus + Ganitumab Everolimus Ganitumab 0 1
Everolimus + Ganitumab + Panitumumab Everolimus Ganitumab Panitumumab 0 1
Everolimus + Gemcitabine Everolimus Gemcitabine 0 1
Everolimus + Giredestrant Everolimus Giredestrant 0 2
Everolimus + H3B-5942 Everolimus H3B-5942 0 0
Everolimus + Hydroxychloroquine Everolimus Hydroxychloroquine 0 2
Everolimus + Ibrutinib Everolimus Ibrutinib 0 1
Everolimus + Imatinib Everolimus Imatinib 0 1
Everolimus + Itacitinib Everolimus Itacitinib 0 1
Everolimus + IWR-1 Everolimus IWR-1 0 0
Everolimus + JI-101 Everolimus JI-101 0 0
Everolimus + Lapatinib Everolimus Lapatinib 0 1
Everolimus + Lenvatinib Everolimus Lenvatinib 0 8
Everolimus + Letrozole Everolimus Letrozole 0 5
Everolimus + Letrozole + Metformin Everolimus Letrozole Metformin 0 0
Everolimus + Letrozole + Ribociclib Everolimus Letrozole Ribociclib 0 1
Everolimus + Letrozole + Trastuzumab Everolimus Letrozole Trastuzumab 0 1
Everolimus + Linsitinib Everolimus Linsitinib 0 0
Everolimus + Linsitinib + Trametinib Everolimus Linsitinib Trametinib 0 0
Everolimus + Lorlatinib Everolimus Lorlatinib 0 0
Everolimus + LY3484356 Everolimus LY3484356 0 1
Everolimus + MEN1611 Everolimus MEN1611 0 0
Everolimus + Metformin Everolimus Metformin 0 0
Everolimus + MM-141 Everolimus MM-141 0 1
Everolimus + Navitoclax Everolimus Navitoclax 0 0
Everolimus + Nelarabine Everolimus Nelarabine 0 0
Everolimus + Neratinib Everolimus Neratinib 0 1
Everolimus + Niraparib Everolimus Niraparib 0 1
Everolimus + NVP-AEW541 Everolimus NVP-AEW541 0 0
Everolimus + Octreotide Everolimus Octreotide 0 0
Everolimus + Octreotide acetate Everolimus Octreotide acetate 0 1
Everolimus + Olaparib Everolimus Olaparib 0 0
Everolimus + Osimertinib Everolimus Osimertinib 0 0
Everolimus + Paclitaxel Everolimus Paclitaxel 0 0
Everolimus + Palbociclib Everolimus Palbociclib 2 0
Everolimus + Panobinostat Everolimus Panobinostat 0 4
Everolimus + Pasireotide Everolimus Pasireotide 0 2
Everolimus + Pazopanib Everolimus Pazopanib 0 1
Everolimus + Pictilisib + Trametinib Everolimus Pictilisib Trametinib 0 0
Everolimus + Pimasertib Everolimus Pimasertib 3 0
Everolimus + PLX4720 Everolimus PLX4720 1 0
Everolimus + PLX8394 Everolimus PLX8394 0 0
Everolimus + PRT1419 Everolimus PRT1419 1 0
Everolimus + Radiotherapy Everolimus Radiotherapy 1 0
Everolimus + Ribociclib Everolimus Ribociclib 0 7
Everolimus + Rivoceranib Everolimus Rivoceranib 0 0
Everolimus + RO5126766 Everolimus RO5126766 1 1
Everolimus + RX-0201 Everolimus RX-0201 0 1
Everolimus + SCH772984 Everolimus SCH772984 0 0
Everolimus + Selumetinib Everolimus Selumetinib 5 0
Everolimus + Sonidegib Everolimus Sonidegib 0 1
Everolimus + Sorafenib Everolimus Sorafenib 1 2
Everolimus + Sotorasib Everolimus Sotorasib 0 1
Everolimus + Sotrastaurin Everolimus Sotrastaurin 0 1
Everolimus + Spartalizumab Everolimus Spartalizumab 0 1
Everolimus + Sunitinib Everolimus Sunitinib 0 0
Everolimus + Tacrolimus Everolimus Tacrolimus 0 0
Everolimus + Talazoparib Everolimus Talazoparib 0 0
Everolimus + Tamoxifen Everolimus Tamoxifen 0 3
Everolimus + Taselisib Everolimus Taselisib 0 0
Everolimus + Tazemetostat Everolimus Tazemetostat 0 0
Everolimus + Telaglenastat Everolimus Telaglenastat 0 2
Everolimus + Temozolomide Everolimus Temozolomide 0 0
Everolimus + Toremifene Everolimus Toremifene 0 1
Everolimus + Trametinib Everolimus Trametinib 0 2
Everolimus + Trastuzumab Everolimus Trastuzumab 0 0
Everolimus + Trastuzumab + Vinorelbine Everolimus Trastuzumab Vinorelbine 0 1
Everolimus + U0126 Everolimus U0126 1 0
Everolimus + Vandetanib Everolimus Vandetanib 2 1
Everolimus + Vatalanib Everolimus Vatalanib 0 0
Everolimus + Vemurafenib Everolimus Vemurafenib 0 1
Everolimus + Vepdegestrant Everolimus Vepdegestrant 0 1
Everolimus + Vorinostat Everolimus Vorinostat 0 0
Everolimus + Vorolanib Everolimus Vorolanib 0 1
Everolimus + XAV939 Everolimus XAV939 0 0


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