Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name U0126
Trade Name
Synonyms
Drug Descriptions

U0126 binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 9873633).

DrugClasses MEK inhibitor (Pan) 24 MEK1 Inhibitor 26 MEK2 Inhibitor 24
CAS Registry Number 1173097-76-1
NCIT ID NA

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + U0126 Cetuximab U0126 0 0
Dactolisib + U0126 Dactolisib U0126 0 0
Darinaparsin + U0126 Darinaparsin U0126 0 0
Everolimus + U0126 Everolimus U0126 1 0
Torkinib + U0126 Torkinib U0126 1 0
U0126 U0126 6 0


Additional content available in CKB BOOST