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Therapy Name Darinaparsin + U0126
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Darinaparsin ZIO-101|ZIO101|ZIO 101|S-Dimethylarsino-Glutathione|DMAIII(SG) Darinaparsin, is an arsenic containing compound that inhibits signaling via the MAPK and Hedgehog signaling pathways (PMID: 25381261, 25316819), potentially leading to tumor growth inhibition and tumor cell killing (PMID: 25381261, PMID: 25316819, PMID: 30080396).
U0126 MEK inhibitor (Pan) 22 MEK1 Inhibitor 20 MEK2 Inhibitor 18 U0126 binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 9873633).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Hodgkin's lymphoma not applicable Darinaparsin + U0126 Preclinical - Cell culture Actionable In a preclinical study, Darinaparsin treatment in combination with U0126 inhibited Erk1/2 phosphorylation and led to enhanced apoptosis in Hodgkin's lymphoma cells compared to Darinaparsin treatment alone in culture (PMID: 25316819). 25316819

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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