Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Dactolisib
Trade Name
Synonyms NVP-BEZ235|BEZ235
Drug Descriptions

Dactolisib (BEZ235) inhibits PI3K kinase, mTOR kinase, and ATR, which may result in tumor cell apoptosis and growth inhibition of tumor cells (PMID: 18606717, PMID: 21552262, PMID: 32088816).

DrugClasses ATR Inhibitor 10 mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Dactolisib Abiraterone Dactolisib 1 0
ABT-737 + Dactolisib ABT-737 Dactolisib 0 0
ABT-737 + Dactolisib + Trametinib ABT-737 Dactolisib Trametinib 1 0
Aldoxorubicin + Dactolisib Aldoxorubicin Dactolisib 1 0
Binimetinib + Dactolisib Binimetinib Dactolisib 0 0
Dactolisib Dactolisib 24 0
Dactolisib + Docetaxel Dactolisib Docetaxel 0 0
Dactolisib + Everolimus Dactolisib Everolimus 2 1
Dactolisib + Palbociclib Dactolisib Palbociclib 0 0
Dactolisib + PD-0325901 Dactolisib PD-0325901 0 0
Dactolisib + PD98059 Dactolisib PD98059 0 0
Dactolisib + Pimasertib Dactolisib Pimasertib 0 0
Dactolisib + PU-H71 Dactolisib PU-H71 0 0
Dactolisib + Ruxolitinib Dactolisib Ruxolitinib 5 0
Dactolisib + Selumetinib Dactolisib Selumetinib 1 0
Dactolisib + Sorafenib Dactolisib Sorafenib 1 0
Dactolisib + U0126 Dactolisib U0126 0 0
Dactolisib + unspecified CTLA4 antibody + unspecified PD-1 antibody Dactolisib unspecified CTLA4 antibody unspecified PD-1 antibody 1 0
Dactolisib + Vemurafenib Dactolisib Vemurafenib 1 0
Dactolisib + Venetoclax Dactolisib Venetoclax 2 0
Dactolisib + WEHI-539 Dactolisib WEHI-539 3 0


Additional content available in CKB BOOST