Drug Detail

Drug Name Selumetinib
Trade Name
Synonyms AZD6244|ARRY-142886
Drug Descriptions

Selumetinib (AZD6244) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210).

DrugClasses MEK inhibitor (Pan) 21 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Selumetinib Afatinib Selumetinib 0 0
Amlexanox + Selumetinib Amlexanox Selumetinib 2 0
APS-2-79 + Selumetinib APS-2-79 Selumetinib 0 0
AZ-TAK1 + Selumetinib AZ-TAK1 Selumetinib 0 0
AZ628 + Selumetinib AZ628 Selumetinib 1 0
Azacitidine + Selumetinib Azacitidine Selumetinib 0 1
AZD8055 + Selumetinib AZD8055 Selumetinib 1 0
AZD9150 + Selumetinib AZD9150 Selumetinib 0 0
BEZ235 + Selumetinib BEZ235 Selumetinib 3 0
Buparlisib + Selumetinib Buparlisib Selumetinib 1 0
Cediranib + PLX4720 + Selumetinib Cediranib PLX4720 Selumetinib 1 0
Ceritinib + Selumetinib Ceritinib Selumetinib 1 0
Cetuximab + Selumetinib Cetuximab Selumetinib 4 0
Cetuximab + Selumetinib + Vemurafenib Cetuximab Selumetinib Vemurafenib 1 0
Cisplatin + Gemcitabine + Selumetinib Cisplatin Gemcitabine Selumetinib 0 1
Dabrafenib + Selumetinib Dabrafenib Selumetinib 0 0
Dacarbazine + Selumetinib Dacarbazine Selumetinib 3 1
Dasatinib + Selumetinib Dasatinib Selumetinib 2 0
Docetaxel + Selumetinib Docetaxel Selumetinib 1 3
Durvalumab + Paclitaxel + Selumetinib Durvalumab Paclitaxel Selumetinib 0 1
Durvalumab + Selumetinib Durvalumab Selumetinib 0 3
Durvalumab + Selumetinib + Tremelimumab Durvalumab Selumetinib Tremelimumab 0 1
DZNeP + Selumetinib DZNeP Selumetinib 0 0
Erlotinib + Selumetinib Erlotinib Selumetinib 1 0
Everolimus + Selumetinib Everolimus Selumetinib 5 0
Fulvestrant + Selumetinib Fulvestrant Selumetinib 0 0
GLPG0634 + Selumetinib GLPG0634 Selumetinib 0 0
GS-493 + Selumetinib GS-493 Selumetinib 0 0
GSK343 + Selumetinib GSK343 Selumetinib 0 0
GSK525762 + Selumetinib GSK525762 Selumetinib 0 0
Ipatasertib + Selumetinib Ipatasertib Selumetinib 0 0
Irinotecan + Selumetinib Irinotecan Selumetinib 0 0
KW-2450 + Selumetinib KW-2450 Selumetinib 1 0
Linsitinib + Selumetinib Linsitinib Selumetinib 0 0
LY5 + Selumetinib LY5 Selumetinib 0 0
MK-8353 + Selumetinib MK-8353 Selumetinib 0 1
MK2206 + Selumetinib MK2206 Selumetinib 1 1
MLN2480 + Selumetinib MLN2480 Selumetinib 0 0
Neratinib + Selumetinib Neratinib Selumetinib 0 0
Olaparib + Selumetinib Olaparib Selumetinib 0 1
Osimertinib + Selumetinib Osimertinib Selumetinib 7 2
Paclitaxel + Selumetinib Paclitaxel Selumetinib 0 1
Palbociclib + Selumetinib Palbociclib Selumetinib 0 0
Pembrolizumab + Selumetinib Pembrolizumab Selumetinib 0 1
Pictilisib + Selumetinib Pictilisib Selumetinib 0 0
PLX4720 + Selumetinib PLX4720 Selumetinib 3 0
RAF265 + Selumetinib RAF265 Selumetinib 0 0
Ruxolitinib + Selumetinib Ruxolitinib Selumetinib 0 0
SAR260301 + Selumetinib SAR260301 Selumetinib 1 0
Saracatinib + Selumetinib Saracatinib Selumetinib 0 0
Selumetinib Selumetinib 66 17
Selumetinib + SHP099 SHP099 Selumetinib 4 0
Selumetinib + Sirolimus Selumetinib Sirolimus 0 1
Selumetinib + Sorafenib Selumetinib Sorafenib 1 0
Selumetinib + Tazemetostat Selumetinib Tazemetostat 0 0
Selumetinib + Torkinib Selumetinib Torkinib 1 0
Selumetinib + Vemurafenib Selumetinib Vemurafenib 4 0
Selumetinib + ZSTK474 Selumetinib ZSTK474 1 0


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