Drug Detail

Drug Name Selumetinib
Trade Name
Synonyms AZD6244|ARRY-142886
Drug Descriptions

Selumetinib (AZD6244) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210).

DrugClasses MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Therapy Description
Cetuximab + Selumetinib + Vemurafenib
Durvalumab + Paclitaxel + Selumetinib
MK2206 + Selumetinib
Ruxolitinib + Selumetinib
AZ-TAK1 + Selumetinib
Azacitidine + Selumetinib
GSK525762 + Selumetinib
KW-2450 + Selumetinib
Ceritinib + Selumetinib
Neratinib + Selumetinib
Selumetinib + BEZ235
Irinotecan + Selumetinib
RAF265 + Selumetinib
Selumetinib + Tazemetostat
PD0332991 + AZD6244
LY5 + Selumetinib
Amlexanox + Selumetinib
Olaparib + Selumetinib
Erlotinib + Selumetinib
Fulvestrant + Selumetinib
Dabrafenib + Selumetinib
Selumetinib + Vemurafenib
Selumetinib + PLX4720
Everolimus + Selumetinib
Dasatinib + Selumetinib
BKM120 + Selumetinib
Selumetinib + Paclitaxel
MLN2480 + Selumetinib
AZD9150 + Selumetinib
Selumetinib + Sorafenib
Selumetinib + Docetaxel
AZ628 + Selumetinib
DZNep + Selumetinib
SAR260301 + Selumetinib
Linsitinib + Selumetinib
Selumetinib
Ipatasertib + Selumetinib
Selumetinib + Dacarbazine
Durvalumab + Selumetinib + Tremelimumab
MEDI4736 + Selumetinib
Selumetinib + SHP099
Selumetinib + ZSTK474
APS-2-79 + Selumetinib
GSK343 + Selumetinib
Pictilisib + Selumetinib
Selumetinib + Torkinib
Osimertinib + Selumetinib
GLPG0634 + Selumetinib
GS-493 + Selumetinib
MK-8353 + Selumetinib Selumetinib (AZD6244) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210).
Afatinib + Selumetinib
Saracatinib + Selumetinib
Cetuximab + Selumetinib
Cediranib + Selumetinib + PLX4720
AZD8055 + Selumetinib
Selumetinib + Cisplatin + Gemcitabine