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Drug Name Selumetinib
Trade Name Koselugo
Synonyms AZD6244|ARRY-142886
Drug Descriptions

Koselugo (selumetinib) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210). Koselugo (selumetinib) is FDA approved for use in pediatric patients of 2 years or older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (FDA.gov).

DrugClasses MEK inhibitor (Pan) 24 MEK1 Inhibitor 26 MEK2 Inhibitor 24
CAS Registry Number 606143-52-6
NCIT ID C66939

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Therapy Name Drugs Efficacy Evidence Clinical Trials
4SC-205 + Selumetinib 4SC-205 Selumetinib 1 0
Afatinib + Selumetinib Afatinib Selumetinib 0 0
Alectinib + Selumetinib Alectinib Selumetinib 1 0
AMG 176 + Selumetinib AMG 176 Selumetinib 1 0
Amlexanox + Selumetinib Amlexanox Selumetinib 0 0
APS-2-79 + Selumetinib APS-2-79 Selumetinib 0 0
AZ-TAK1 + Selumetinib AZ-TAK1 Selumetinib 0 0
AZ628 + Selumetinib AZ628 Selumetinib 1 0
Azacitidine + Selumetinib Azacitidine Selumetinib 0 1
AZD0364 + Selumetinib AZD0364 Selumetinib 0 0
AZD5153 + Durvalumab + Selumetinib AZD5153 Durvalumab Selumetinib 0 1
AZD5153 + Selumetinib AZD5153 Selumetinib 0 1
AZD5991 + Selumetinib AZD5991 Selumetinib 1 0
AZD8055 + Selumetinib AZD8055 Selumetinib 0 0
BCL201 + Selumetinib BCL201 Selumetinib 1 0
BI-1347 + Selumetinib BI-1347 Selumetinib 1 0
BI-3406 + Selumetinib BI-3406 Selumetinib 0 0
Buparlisib + Selumetinib Buparlisib Selumetinib 7 0
Cediranib + PLX4720 + Selumetinib Cediranib PLX4720 Selumetinib 1 0
Ceritinib + Selumetinib Ceritinib Selumetinib 1 0
Cetuximab + Selumetinib Cetuximab Selumetinib 4 0
Cetuximab + Selumetinib + Vemurafenib Cetuximab Selumetinib Vemurafenib 0 0
Cisplatin + Gemcitabine + Selumetinib Cisplatin Gemcitabine Selumetinib 0 1
Cobimetinib + Selumetinib Cobimetinib Selumetinib 0 0
Crizotinib + Selumetinib Crizotinib Selumetinib 0 0
Dabrafenib + Selumetinib Dabrafenib Selumetinib 0 0
Dacarbazine + Selumetinib Dacarbazine Selumetinib 0 1
Dacomitinib + Selumetinib Dacomitinib Selumetinib 0 0
Dactolisib + Selumetinib Dactolisib Selumetinib 2 0
Danvatirsen + Selumetinib Danvatirsen Selumetinib 0 0
Darinaparsin + Selumetinib Darinaparsin Selumetinib 0 0
Dasatinib + Selumetinib Dasatinib Selumetinib 2 0
Dexamethasone + Selumetinib Dexamethasone Selumetinib 0 0
Docetaxel + Selumetinib Docetaxel Selumetinib 0 3
Durvalumab + Paclitaxel + Selumetinib Durvalumab Paclitaxel Selumetinib 0 0
Durvalumab + Selumetinib Durvalumab Selumetinib 0 4
Durvalumab + Selumetinib + Tremelimumab Durvalumab Selumetinib Tremelimumab 0 1
DZNeP + Selumetinib DZNeP Selumetinib 0 0
Entrectinib + Selumetinib Entrectinib Selumetinib 0 0
Erlotinib + Selumetinib Erlotinib Selumetinib 0 0
Everolimus + Selumetinib Everolimus Selumetinib 5 0
Filgotinib + Selumetinib Filgotinib Selumetinib 0 0
Fulvestrant + Selumetinib Fulvestrant Selumetinib 0 0
GS-493 + Selumetinib GS-493 Selumetinib 0 0
GSK343 + Selumetinib GSK343 Selumetinib 0 0
Ipatasertib + Selumetinib Ipatasertib Selumetinib 0 0
Irinotecan + Selumetinib Irinotecan Selumetinib 0 0
KW-2450 + Selumetinib KW-2450 Selumetinib 0 0
Lapatinib + Selumetinib Lapatinib Selumetinib 0 0
Lazertinib + Selumetinib Lazertinib Selumetinib 0 0
Lifirafenib + Selumetinib Lifirafenib Selumetinib 0 0
Linsitinib + Selumetinib Linsitinib Selumetinib 0 0
Lorlatinib + Selumetinib Lorlatinib Selumetinib 0 0
LY5 + Selumetinib LY5 Selumetinib 0 0
MK-8353 + Selumetinib MK-8353 Selumetinib 0 1
MK2206 + Selumetinib MK2206 Selumetinib 0 1
Molibresib + Selumetinib Molibresib Selumetinib 0 0
Neratinib + Selumetinib Neratinib Selumetinib 0 0
NVP-TNKS656 + Selumetinib NVP-TNKS656 Selumetinib 0 0
Olaparib + Selumetinib Olaparib Selumetinib 0 4
Osimertinib + Selumetinib Osimertinib Selumetinib 0 2
Paclitaxel + Selumetinib Paclitaxel Selumetinib 0 1
Palbociclib + Selumetinib Palbociclib Selumetinib 0 0
Pembrolizumab + Selumetinib Pembrolizumab Selumetinib 0 1
Pictilisib + Selumetinib Pictilisib Selumetinib 0 0
PLX4720 + Selumetinib PLX4720 Selumetinib 3 0
RAF265 + Selumetinib RAF265 Selumetinib 0 0
RAF709 + Selumetinib RAF709 Selumetinib 0 0
Ruxolitinib + Selumetinib Ruxolitinib Selumetinib 0 0
SAR260301 + Selumetinib SAR260301 Selumetinib 1 0
Saracatinib + Selumetinib Saracatinib Selumetinib 0 0
SCH772984 + Selumetinib SCH772984 Selumetinib 0 0
Selumetinib Selumetinib 68 26
Selumetinib + SHP099 SHP099 Selumetinib 0 0
Selumetinib + Sirolimus Selumetinib Sirolimus 0 1
Selumetinib + Sorafenib Selumetinib Sorafenib 0 0
Selumetinib + Sotorasib Selumetinib Sotorasib 0 0
Selumetinib + Tazemetostat Selumetinib Tazemetostat 0 0
Selumetinib + Torkinib Selumetinib Torkinib 1 0
Selumetinib + Tovorafenib Selumetinib Tovorafenib 0 0
Selumetinib + Ulixertinib Selumetinib Ulixertinib 1 0
Selumetinib + Vemurafenib Selumetinib Vemurafenib 2 0
Selumetinib + Venetoclax Selumetinib Venetoclax 1 0
Selumetinib + Vinblastine Selumetinib Vinblastine 0 1
Selumetinib + Vistusertib Selumetinib Vistusertib 0 0
Selumetinib + VS-4718 Selumetinib VS-4718 0 0
Selumetinib + ZSTK474 Selumetinib ZSTK474 1 0


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