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| Drug Name | Selumetinib |
| Trade Name | Koselugo |
| Synonyms | AZD6244|ARRY-142886 |
| Drug Descriptions |
Koselugo (selumetinib) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210). Koselugo (selumetinib) is FDA approved for use in pediatric patients of 2 years or older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (FDA.gov). |
| DrugClasses | MEK inhibitor (Pan) 24 MEK1 Inhibitor 26 MEK2 Inhibitor 24 |
| CAS Registry Number | 606143-52-6 |
| NCIT ID | C66939 |
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