Drug Detail


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Drug Name BI-3406
Trade Name
Synonyms HY-125817|EX-A3418|BI3406|BI 3406
Drug Descriptions

BI-3406 binds to SOS1 thus prevents SOS1 interaction with Kras-GDP, resulting in inhibition of Kras downstream signaling and potential inhibition of tumor cell growth (AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Oct 2019, Abstract PL06-01, PMID: 32816843).

DrugClasses SOS1 Inhibitor 13
CAS Registry Number 2230836-55-0


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BI-3406 BI-3406 5 0
BI-3406 + Selumetinib BI-3406 Selumetinib 0 0
BI-3406 + Sotorasib BI-3406 Sotorasib 0 0
BI-3406 + TNO155 BI-3406 TNO155 0 0
BI-3406 + Trametinib BI-3406 Trametinib 0 0

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