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Drug Name Sotorasib
Trade Name Lumakras
Synonyms AMG 510|AMG510|AMG-510
Drug Descriptions

Lumakras (sotorasib) is small molecule inhibitor that selectively targets KRAS G12C and inhibits downstream signaling, which may lead to growth inhibition of tumors harboring KRAS G12C (PMID: 31666701). Lumakras (sotorasib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring KRAS G12C who have received one or more prior therapy (FDA.gov).

DrugClasses KRAS G12C inhibitor 15
CAS Registry Number 2252403-56-6
NCIT ID C154287

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Sotorasib Afatinib Sotorasib 0 0
AMG 511 + Sotorasib AMG 511 Sotorasib 0 0
BI-3406 + Sotorasib BI-3406 Sotorasib 0 0
Capivasertib + Sotorasib Capivasertib Sotorasib 0 0
Capmatinib + Sotorasib Capmatinib Sotorasib 0 0
Carboplatin + Pemetrexed Disodium + Sotorasib Carboplatin Pemetrexed Disodium Sotorasib 0 1
Carboplatin + Sotorasib Carboplatin Sotorasib 0 0
Cetuximab + Sotorasib Cetuximab Sotorasib 0 0
Cisplatin + Pemetrexed Disodium + Sotorasib Cisplatin Pemetrexed Disodium Sotorasib 0 1
Crizotinib + Sotorasib Crizotinib Sotorasib 0 0
Erlotinib + Sotorasib Erlotinib Sotorasib 0 0
Gilteritinib + Sotorasib Gilteritinib Sotorasib 0 0
PD-0325901 + Sotorasib PD-0325901 Sotorasib 0 0
Repotrectinib + Sotorasib Repotrectinib Sotorasib 0 0
RMC-4550 + Sotorasib RMC-4550 Sotorasib 0 0
RMC-4630 + Sotorasib RMC-4630 Sotorasib 0 1
Selumetinib + Sotorasib Selumetinib Sotorasib 0 0
Sotorasib Sotorasib 0 5
Sotorasib + TNO155 Sotorasib TNO155 0 0
Sotorasib + Trametinib Sotorasib Trametinib 0 0
Sotorasib + unspecified PD-1 antibody Sotorasib unspecified PD-1 antibody 0 1
Sotorasib + unspecified PD-L1 antibody Sotorasib unspecified PD-L1 antibody 0 1


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