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Drug Name AMG 510
Trade Name
Synonyms AMG510|AMG-510|Sotorasib
Drug Descriptions

Sotorasib (AMG 510) is small molecule inhibitor that selectively targets KRAS G12C and inhibits downstream signaling, which may lead to growth inhibition of tumors harboring KRAS G12C (PMID: 31666701).

DrugClasses KRAS G12C inhibitor 7

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + AMG 510 AMG 510 Afatinib 0 0
AMG 510 AMG 510 0 3
AMG 510 + AMG 511 AMG 510 AMG 511 0 0
AMG 510 + Capivasertib AMG 510 Capivasertib 0 0
AMG 510 + Carboplatin AMG 510 Carboplatin 0 0
AMG 510 + Cetuximab AMG 510 Cetuximab 0 0
AMG 510 + Erlotinib AMG 510 Erlotinib 0 0
AMG 510 + PD-0325901 AMG 510 PD-0325901 0 0
AMG 510 + Repotrectinib AMG 510 Repotrectinib 0 0
AMG 510 + RMC-4550 AMG 510 RMC-4550 0 0
AMG 510 + Trametinib AMG 510 Trametinib 0 0
AMG 510 + unspecified PD-1 antibody AMG 510 unspecified PD-1 antibody 0 1


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