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Drug Name Sotorasib
Trade Name Lumakras
Synonyms AMG 510|AMG510|AMG-510|Lumykras
Drug Descriptions

Lumakras (sotorasib) is small molecule inhibitor that selectively targets KRAS G12C and inhibits downstream signaling, which may lead to growth inhibition of tumors harboring KRAS G12C (PMID: 31666701). Lumakras (sotorasib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring KRAS G12C who have received one or more prior therapy (FDA.gov).

DrugClasses KRAS G12C inhibitor 33
CAS Registry Number 2252403-56-6
NCIT ID C154287

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib + Sotorasib Adavosertib Sotorasib 0 0
Afatinib + Sotorasib Afatinib Sotorasib 0 1
Alpelisib + RMC-4550 + Sotorasib Alpelisib RMC-4550 Sotorasib 0 0
Alpelisib + Sotorasib Alpelisib Sotorasib 0 0
AMG 404 + Sotorasib AMG 404 Sotorasib 0 1
AMG 511 + Sotorasib AMG 511 Sotorasib 0 0
AMG193 + Sotorasib AMG193 Sotorasib 0 1
AMT-562 + Sotorasib AMT-562 Sotorasib 0 0
Atezolizumab + Sotorasib Atezolizumab Sotorasib 0 1
BBP-398 + Sotorasib BBP-398 Sotorasib 0 1
Bevacizumab + Sotorasib Bevacizumab Sotorasib 0 0
Bevacizumab-awwb + Fluorouracil + Irinotecan + Sotorasib Bevacizumab-awwb Fluorouracil Irinotecan Sotorasib 0 1
Bevacizumab-awwb + Fluorouracil + Oxaliplatin + Sotorasib Bevacizumab-awwb Fluorouracil Oxaliplatin Sotorasib 0 1
Bevacizumab-awwb + Sotorasib Bevacizumab-awwb Sotorasib 0 1
BI 1701963 + Sotorasib BI 1701963 Sotorasib 0 1
BI-3406 + Sotorasib BI-3406 Sotorasib 0 0
BTX-6654 + Sotorasib BTX-6654 Sotorasib 0 0
BTX-7312 + Sotorasib BTX-7312 Sotorasib 0 0
Capivasertib + Sotorasib Capivasertib Sotorasib 0 0
Capmatinib + Sotorasib Capmatinib Sotorasib 0 0
Carboplatin + Docetaxel + Paclitaxel + Pembrolizumab + Pemetrexed Disodium + Sotorasib Carboplatin Docetaxel Paclitaxel Pembrolizumab Pemetrexed Disodium Sotorasib 0 1
Carboplatin + Pemetrexed Disodium + Sotorasib Carboplatin Pemetrexed Disodium Sotorasib 0 2
Carboplatin + Sotorasib Carboplatin Sotorasib 0 0
Carfilzomib + Sotorasib Carfilzomib Sotorasib 0 1
Cetuximab + Erdafitinib + Sotorasib Cetuximab Erdafitinib Sotorasib 0 0
Cetuximab + Sotorasib Cetuximab Sotorasib 0 0
Cisplatin + Pemetrexed Disodium + Sotorasib Cisplatin Pemetrexed Disodium Sotorasib 0 1
Copanlisib + Sotorasib Copanlisib Sotorasib 0 0
Crizotinib + Sotorasib Crizotinib Sotorasib 0 0
Dasatinib + Sotorasib Dasatinib Sotorasib 0 0
DCC-3116 + Sotorasib DCC-3116 Sotorasib 0 1
Defactinib + RO5126766 + Sotorasib Defactinib RO5126766 Sotorasib 0 1
DT2216 + Sotorasib DT2216 Sotorasib 0 0
Entrectinib + Sotorasib Entrectinib Sotorasib 0 0
ERAS-007 + Sotorasib ERAS-007 Sotorasib 0 1
ERAS-601 + Sotorasib ERAS-601 Sotorasib 0 1
Erdafitinib + Erlotinib + Sotorasib Erdafitinib Erlotinib Sotorasib 0 0
Erlotinib + Sotorasib Erlotinib Sotorasib 0 0
Everolimus + Sotorasib Everolimus Sotorasib 0 1
Fluorouracil + Irinotecan + Leucovorin + Panitumumab + Sotorasib Fluorouracil Irinotecan Leucovorin Panitumumab Sotorasib 0 0
Fluorouracil + Irinotecan + Panitumumab + Sotorasib Fluorouracil Irinotecan Panitumumab Sotorasib 0 1
Fluorouracil + Leucovorin + Liposomal irinotecan + Sotorasib Fluorouracil Leucovorin Liposomal irinotecan Sotorasib 0 1
FRAX597 + Sotorasib FRAX597 Sotorasib 0 0
Gemcitabine + Nab-paclitaxel + Sotorasib Gemcitabine Nab-paclitaxel Sotorasib 0 1
Gilteritinib + Sotorasib Gilteritinib Sotorasib 0 0
GNE-7883 + Sotorasib GNE-7883 Sotorasib 0 0
HRX-0233 + Sotorasib HRX-0233 Sotorasib 0 0
Ipatasertib + RMC-4550 + Sotorasib Ipatasertib RMC-4550 Sotorasib 0 0
JSI-1187 + Sotorasib JSI-1187 Sotorasib 0 0
KPT-9274 + Sotorasib KPT-9274 Sotorasib 0 0
Ladarixin + Sotorasib Ladarixin Sotorasib 0 2
Lenvatinib + Sotorasib Lenvatinib Sotorasib 0 1
Lonafarnib + Sotorasib Lonafarnib Sotorasib 0 0
Midazolam + Sotorasib Midazolam Sotorasib 0 1
Mubritinib + Sotorasib Mubritinib Sotorasib 0 0
Neratinib + Sotorasib Neratinib Sotorasib 0 0
Osimertinib + Sotorasib Osimertinib Sotorasib 0 0
Palbociclib + Sotorasib Palbociclib Sotorasib 0 1
Panitumumab + Sotorasib Panitumumab Sotorasib 2 3
Panitumumab + Sotorasib + Trametinib Panitumumab Sotorasib Trametinib 0 1
Panobinostat + Sotorasib Panobinostat Sotorasib 0 0
PD-0325901 + Sotorasib PD-0325901 Sotorasib 0 0
Pembrolizumab + Sotorasib Pembrolizumab Sotorasib 0 1
Pictilisib + RMC-4550 + Sotorasib Pictilisib RMC-4550 Sotorasib 0 0
Repotrectinib + Sotorasib Repotrectinib Sotorasib 0 0
RMC-4550 + Sotorasib RMC-4550 Sotorasib 0 0
RMC-4630 + Sotorasib RMC-4630 Sotorasib 0 2
RO5126766 + Sotorasib RO5126766 Sotorasib 0 1
Selinexor + Sotorasib Selinexor Sotorasib 0 0
Selumetinib + Sotorasib Selumetinib Sotorasib 0 0
Sotorasib Sotorasib 3 11
Sotorasib + Tepotinib Sotorasib Tepotinib 0 0
Sotorasib + TH-4000 Sotorasib TH-4000 0 1
Sotorasib + Tipifarnib Sotorasib Tipifarnib 0 0
Sotorasib + TNO155 Sotorasib TNO155 0 1
Sotorasib + Trametinib Sotorasib Trametinib 0 0
Sotorasib + TT125-802 Sotorasib TT125-802 0 0
Sotorasib + Tunlametinib Sotorasib Tunlametinib 0 0
Sotorasib + unspecified PD-1 antibody Sotorasib unspecified PD-1 antibody 0 1
Sotorasib + unspecified PD-L1 antibody Sotorasib unspecified PD-L1 antibody 0 1
Sotorasib + VIC-1911 Sotorasib VIC-1911 0 1
Sotorasib + Zotatifin Sotorasib Zotatifin 0 1


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