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Drug Name MM-398
Trade Name
Synonyms PEP02|nal-IRI|Liposomal irinotecan|Irinotecan Sucrosofate
Drug Descriptions

MM-398 (liposomal irinotecan) comprises irinotecan encapsulated in liposomal nanoparticles, which may result in increased tumor growth inhibition (PMID: 23406728, PMID: 16540680, PMID: 29945562).

DrugClasses
CAS Registry Number 1361317-83-0
NCIT ID C82676

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + MM-398 Bevacizumab MM-398 0 1
BKT140 + Fluorouracil + Leucovorin + MM-398 + Pembrolizumab BKT140 Fluorouracil Leucovorin MM-398 Pembrolizumab 0 0
Cyclophosphamide + MM-398 Cyclophosphamide MM-398 0 1
Fluorouracil + Leucovorin + MM-398 Fluorouracil Leucovorin MM-398 0 1
Fluorouracil + Leucovorin + MM-398 + Onvansertib Fluorouracil Leucovorin MM-398 Onvansertib 0 1
Fluorouracil + Leucovorin + MM-398 + Rucaparib Fluorouracil Leucovorin MM-398 Rucaparib 0 1
Fluorouracil + MM-398 + Oxaliplatin Fluorouracil MM-398 Oxaliplatin 0 1
Fluorouracil + MM-398 + Oxaliplatin + Trastuzumab Fluorouracil MM-398 Oxaliplatin Trastuzumab 0 1
Fluorouracil + MM-398 + SHR-1316 Fluorouracil MM-398 SHR-1316 0 0
MM-398 MM-398 0 0
MM-398 + Pembrolizumab MM-398 Pembrolizumab 0 1
MM-398 + Ramucirumab MM-398 Ramucirumab 0 1
MM-398 + Trifluridine-tipiracil hydrochloride MM-398 Trifluridine-tipiracil hydrochloride 0 1
MM-398 + Veliparib MM-398 Veliparib 0 1


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