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Drug Name Trifluridine-tipiracil hydrochloride
Trade Name Lonsurf
Synonyms TAS-102|TAS102|TAS 102|S 95005|S95005|S-95005
Drug Descriptions

Lonsurf (trifluridine/tipiracil hydrochloride) is an oral combination comprised of TFT and a thymidine phosphorylase inhibitor, which can result in DNA fragmentation thereby preventing angiogenesis and tumor growth (PMID: 29226002). Lonsurf (trifluridine/tipiracil hydrochloride) is FDA-approved for use in patients with colorectal cancer, gastric or gastroesophageal junction adenocarcinoma, and in combination with Avastin (bevacizumab) in patients with previously-treated metastatic colorectal cancer (FDA.gov).

DrugClasses
CAS Registry Number 183204-74-2
NCIT ID C102554

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Capecitabine + Trifluridine-tipiracil hydrochloride Bevacizumab Capecitabine Trifluridine-tipiracil hydrochloride 0 1
Bevacizumab + Irinotecan + Oxaliplatin + Trifluridine-tipiracil hydrochloride Bevacizumab Irinotecan Oxaliplatin Trifluridine-tipiracil hydrochloride 0 1
Bevacizumab + Irinotecan + Trifluridine-tipiracil hydrochloride Bevacizumab Irinotecan Trifluridine-tipiracil hydrochloride 0 1
Bevacizumab + Liposomal irinotecan + Trifluridine-tipiracil hydrochloride Bevacizumab Liposomal irinotecan Trifluridine-tipiracil hydrochloride 0 1
Bevacizumab + Trifluridine-tipiracil hydrochloride Bevacizumab Trifluridine-tipiracil hydrochloride 0 4
Binimetinib + Trifluridine-tipiracil hydrochloride Binimetinib Trifluridine-tipiracil hydrochloride 1 0
CA102N + Trifluridine-tipiracil hydrochloride CA102N Trifluridine-tipiracil hydrochloride 0 1
Cabozantinib + Trifluridine-tipiracil hydrochloride Cabozantinib Trifluridine-tipiracil hydrochloride 0 1
Irinotecan + Trifluridine-tipiracil hydrochloride Irinotecan Trifluridine-tipiracil hydrochloride 0 1
Liposomal irinotecan + Trifluridine-tipiracil hydrochloride Liposomal irinotecan Trifluridine-tipiracil hydrochloride 0 1
Nivolumab + Oxaliplatin + Trifluridine-tipiracil hydrochloride Nivolumab Oxaliplatin Trifluridine-tipiracil hydrochloride 0 1
Nivolumab + Trifluridine-tipiracil hydrochloride Nivolumab Trifluridine-tipiracil hydrochloride 0 1
Oxaliplatin + Trifluridine-tipiracil hydrochloride Oxaliplatin Trifluridine-tipiracil hydrochloride 0 1
Panitumumab + Trifluridine-tipiracil hydrochloride Panitumumab Trifluridine-tipiracil hydrochloride 0 1
PolyPEPI1018 + Trifluridine-tipiracil hydrochloride PolyPEPI1018 Trifluridine-tipiracil hydrochloride 0 1
Ramucirumab + Trifluridine-tipiracil hydrochloride Ramucirumab Trifluridine-tipiracil hydrochloride 0 4
Regorafenib + Trifluridine-tipiracil hydrochloride Regorafenib Trifluridine-tipiracil hydrochloride 0 5
Rivoceranib + Trifluridine-tipiracil hydrochloride Rivoceranib Trifluridine-tipiracil hydrochloride 0 1
Talazoparib + Trifluridine-tipiracil hydrochloride Talazoparib Trifluridine-tipiracil hydrochloride 0 1
Trametinib + Trifluridine-tipiracil hydrochloride Trametinib Trifluridine-tipiracil hydrochloride 0 1
Trastuzumab + Trifluridine-tipiracil hydrochloride + Tucatinib Trastuzumab Trifluridine-tipiracil hydrochloride Tucatinib 0 1
Trifluridine-tipiracil hydrochloride Trifluridine-tipiracil hydrochloride 0 22
Trifluridine-tipiracil hydrochloride + UCB6114 Trifluridine-tipiracil hydrochloride UCB6114 0 1
Trifluridine-tipiracil hydrochloride + XB2001 Trifluridine-tipiracil hydrochloride XB2001 0 1


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