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Drug Name trifluridine/tipiracil hydrochloride
Trade Name Lonsurf
Synonyms TAS-102
Drug Descriptions

Lonsurf (trifluridine/tipiracil hydrochloride) is an oral combination comprised of TFT and a thymidine phosphorylase inhibitor, which can result in DNA fragmentation thereby preventing angiogenesis and tumor growth and is FDA approved for use in patients with colorectal cancer, gastric or gastroesophageal junction adenocarcinoma (FDA.gov).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Irinotecan + trifluridine/tipiracil hydrochloride Bevacizumab Irinotecan trifluridine/tipiracil hydrochloride 0 1
Bevacizumab + trifluridine/tipiracil hydrochloride Bevacizumab trifluridine/tipiracil hydrochloride 2 1
CA102N + trifluridine/tipiracil hydrochloride CA102N trifluridine/tipiracil hydrochloride 0 1
Irinotecan + trifluridine/tipiracil hydrochloride Irinotecan trifluridine/tipiracil hydrochloride 0 1
MM-398 + trifluridine/tipiracil hydrochloride MM-398 trifluridine/tipiracil hydrochloride 0 1
Nivolumab + trifluridine/tipiracil hydrochloride Nivolumab trifluridine/tipiracil hydrochloride 0 1
Ramucirumab + trifluridine/tipiracil hydrochloride Ramucirumab trifluridine/tipiracil hydrochloride 0 1
Regorafenib + trifluridine/tipiracil hydrochloride Regorafenib trifluridine/tipiracil hydrochloride 0 1
Rivoceranib + trifluridine/tipiracil hydrochloride Rivoceranib trifluridine/tipiracil hydrochloride 0 1
Trametinib + trifluridine/tipiracil hydrochloride Trametinib trifluridine/tipiracil hydrochloride 0 1
trifluridine/tipiracil hydrochloride trifluridine/tipiracil hydrochloride 3 10


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