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Drug Name Binimetinib
Trade Name Mektovi
Synonyms ARRY-162|ARRY-438162|MEK162
Drug Descriptions

Mektovi (binimetinib) inhibits MEK1 and MEK2 resulting in inhibition of growth factor-mediated signaling and decreased tumor cell proliferation (PMID: 23587417). Mektovi (binimetinib) in combination with Braftovi (encorafenib) is FDA approved for use in patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation (FDA.gov).

DrugClasses MEK inhibitor (Pan) 24 MEK1 Inhibitor 25 MEK2 Inhibitor 23
CAS Registry Number 606143-89-9
NCIT ID C84865

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABM-1310 + Binimetinib ABM-1310 Binimetinib 1 0
Afatinib + Binimetinib Afatinib Binimetinib 0 0
Alpelisib + AZD6482 + Binimetinib AZD6482 Alpelisib Binimetinib 1 0
Alpelisib + AZD6482 + Binimetinib + Encorafenib AZD6482 Alpelisib Binimetinib Encorafenib 1 0
Alpelisib + Binimetinib Alpelisib Binimetinib 6 1
APS-2-79 + Binimetinib APS-2-79 Binimetinib 0 0
Avelumab + Binimetinib Avelumab Binimetinib 0 2
Avelumab + Binimetinib + Talazoparib Avelumab Binimetinib Talazoparib 0 1
AZD6482 + Binimetinib AZD6482 Binimetinib 2 0
AZD6482 + Binimetinib + Encorafenib AZD6482 Binimetinib Encorafenib 0 0
AZD6482 + Binimetinib + Encorafenib + NVP-AEW541 AZD6482 Binimetinib Encorafenib NVP-AEW541 1 0
AZD6482 + Binimetinib + NVP-AEW541 AZD6482 Binimetinib NVP-AEW541 1 0
AZD8055 + Binimetinib AZD8055 Binimetinib 1 0
Belinostat + Binimetinib Belinostat Binimetinib 0 1
Bevacizumab + Binimetinib + Pembrolizumab Bevacizumab Binimetinib Pembrolizumab 0 1
Binimetinib Binimetinib 102 14
Binimetinib + Brigatinib Binimetinib Brigatinib 0 1
Binimetinib + Buparlisib Binimetinib Buparlisib 3 0
Binimetinib + Buparlisib + Encorafenib Binimetinib Buparlisib Encorafenib 0 1
Binimetinib + Capmatinib + Encorafenib Binimetinib Capmatinib Encorafenib 0 1
Binimetinib + Carboplatin + Pemetrexed Disodium Binimetinib Carboplatin Pemetrexed Disodium 0 1
Binimetinib + Cetuximab Binimetinib Cetuximab 1 0
Binimetinib + Cetuximab + Encorafenib Binimetinib Cetuximab Encorafenib 3 5
Binimetinib + CHZ868 Binimetinib CHZ868 1 0
Binimetinib + Cisplatin + Gemcitabine Binimetinib Cisplatin Gemcitabine 0 1
Binimetinib + Cytarabine + Idarubicin Binimetinib Cytarabine Idarubicin 0 1
Binimetinib + Dactolisib Binimetinib Dactolisib 1 0
Binimetinib + DCC-3116 Binimetinib DCC-3116 0 1
Binimetinib + Docetaxel Binimetinib Docetaxel 0 1
Binimetinib + Dovitinib Binimetinib Dovitinib 1 0
Binimetinib + Encorafenib Binimetinib Encorafenib 48 28
Binimetinib + Encorafenib + Infigratinib Binimetinib Encorafenib Infigratinib 0 1
Binimetinib + Encorafenib + Ipilimumab + Nivolumab Binimetinib Encorafenib Ipilimumab Nivolumab 0 1
Binimetinib + Encorafenib + Nivolumab Binimetinib Encorafenib Nivolumab 0 4
Binimetinib + Encorafenib + Palbociclib Binimetinib Encorafenib Palbociclib 0 1
Binimetinib + Encorafenib + Panitumumab Binimetinib Encorafenib Panitumumab 0 0
Binimetinib + Encorafenib + Pembrolizumab Binimetinib Encorafenib Pembrolizumab 1 3
Binimetinib + Encorafenib + PF-06801591 Binimetinib Encorafenib PF-06801591 0 1
Binimetinib + Encorafenib + PF-07284892 Binimetinib Encorafenib PF-07284892 1 0
Binimetinib + Encorafenib + Ribociclib Binimetinib Encorafenib Ribociclib 0 3
Binimetinib + Encorafenib + Talazoparib Binimetinib Encorafenib Talazoparib 3 0
Binimetinib + Erlotinib Binimetinib Erlotinib 0 1
Binimetinib + Everolimus Binimetinib Everolimus 4 0
Binimetinib + Exarafenib Binimetinib Exarafenib 1 1
Binimetinib + Fluorouracil Binimetinib Fluorouracil 0 0
Binimetinib + Fluorouracil + Irinotecan + Leucovorin Binimetinib Fluorouracil Irinotecan Leucovorin 0 1
Binimetinib + Fluorouracil + Irinotecan + Leucovorin + Pembrolizumab Binimetinib Fluorouracil Irinotecan Leucovorin Pembrolizumab 0 1
Binimetinib + Fluorouracil + Leucovorin + Oxaliplatin Binimetinib Fluorouracil Leucovorin Oxaliplatin 0 3
Binimetinib + Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Binimetinib Fluorouracil Leucovorin Oxaliplatin Pembrolizumab 0 1
Binimetinib + Fulvestrant Binimetinib Fulvestrant 0 2
Binimetinib + Futibatinib Binimetinib Futibatinib 0 1
Binimetinib + Ganitumab Binimetinib Ganitumab 0 1
Binimetinib + Gemcitabine + Oxaliplatin Binimetinib Gemcitabine Oxaliplatin 0 1
Binimetinib + GSK2636771 Binimetinib GSK2636771 2 0
Binimetinib + Hydroxychloroquine Binimetinib Hydroxychloroquine 0 2
Binimetinib + IDE196 Binimetinib IDE196 0 0
Binimetinib + Imatinib Binimetinib Imatinib 12 2
Binimetinib + Ipilimumab + Nivolumab Binimetinib Ipilimumab Nivolumab 0 1
Binimetinib + JAB-3312 Binimetinib JAB-3312 0 1
Binimetinib + Lorlatinib Binimetinib Lorlatinib 0 1
Binimetinib + Midazolam + PF-07284890 Binimetinib Midazolam PF-07284890 0 1
Binimetinib + Nilotinib Binimetinib Nilotinib 0 1
Binimetinib + Nivolumab Binimetinib Nivolumab 0 2
Binimetinib + OKI-179 Binimetinib OKI-179 0 1
Binimetinib + Paclitaxel Binimetinib Paclitaxel 0 1
Binimetinib + Palbociclib Binimetinib Palbociclib 0 6
Binimetinib + Panitumumab Binimetinib Panitumumab 1 0
Binimetinib + Pembrolizumab Binimetinib Pembrolizumab 0 2
Binimetinib + Pexidartinib Binimetinib Pexidartinib 0 1
Binimetinib + PF-07284890 Binimetinib PF-07284890 0 1
Binimetinib + PF-07284892 Binimetinib PF-07284892 0 1
Binimetinib + PF-07799933 Binimetinib PF-07799933 0 1
Binimetinib + PF-4708671 + Ribociclib Binimetinib PF-4708671 Ribociclib 2 0
Binimetinib + Pictilisib Binimetinib Pictilisib 1 0
Binimetinib + RAF709 Binimetinib RAF709 3 0
Binimetinib + Ribociclib Binimetinib Ribociclib 10 1
Binimetinib + Ribociclib + Sirolimus Binimetinib Ribociclib Sirolimus 2 0
Binimetinib + Ripretinib Binimetinib Ripretinib 0 1
Binimetinib + Ruxolitinib Binimetinib Ruxolitinib 2 0
Binimetinib + Sotrastaurin Binimetinib Sotrastaurin 0 1
Binimetinib + Tamoxifen Binimetinib Tamoxifen 0 0
Binimetinib + Trifluridine Binimetinib Trifluridine 0 0
Binimetinib + Trifluridine-tipiracil hydrochloride Binimetinib Trifluridine-tipiracil hydrochloride 1 0
Binimetinib + Ulixertinib Binimetinib Ulixertinib 1 0
Binimetinib + YM-254890 Binimetinib YM-254890 0 0
Binimetinib + ZEN-3694 Binimetinib ZEN-3694 0 1


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