Drug Detail

Drug Name Binimetinib
Trade Name Mektovi
Synonyms ARRY-162|ARRY-438162|MEK162
Drug Descriptions

Mektovi (binimetinib) inhibits MEK1 and MEK2 resulting in inhibition of growth factor-mediated signaling and decreased tumor cell proliferation (PMID: 23587417). Mektovi (binimetinib) in combination with Braftovi (encorafenib) is FDA approved for use in patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation (FDA.gov).

DrugClasses MEK inhibitor (Pan) 21 MEK1 Inhibitor 20 MEK2 Inhibitor 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AEB071 + Binimetinib AEB071 Binimetinib 3 1
Alpelisib + AZD6482 + Binimetinib AZD6482 Alpelisib Binimetinib 1 0
Alpelisib + AZD6482 + Binimetinib + Encorafenib AZD6482 Alpelisib Binimetinib Encorafenib 1 0
Alpelisib + Binimetinib Alpelisib Binimetinib 6 1
APS-2-79 + Binimetinib APS-2-79 Binimetinib 0 0
Avelumab + Binimetinib Avelumab Binimetinib 0 2
Avelumab + Binimetinib + Talazoparib Avelumab Binimetinib Talazoparib 0 1
AZD6482 + Binimetinib AZD6482 Binimetinib 2 0
AZD6482 + Binimetinib + Encorafenib AZD6482 Binimetinib Encorafenib 0 0
AZD6482 + Binimetinib + Encorafenib + NVP-AEW541 AZD6482 Binimetinib Encorafenib NVP-AEW541 1 0
AZD6482 + Binimetinib + NVP-AEW541 AZD6482 Binimetinib NVP-AEW541 1 0
AZD8055 + Binimetinib AZD8055 Binimetinib 1 0
Bevacizumab + Binimetinib + Pembrolizumab Bevacizumab Binimetinib Pembrolizumab 0 1
BEZ235 + Binimetinib BEZ235 Binimetinib 1 0
BGJ398 + Binimetinib + Encorafenib BGJ398 Binimetinib Encorafenib 0 1
Binimetinib Binimetinib 28 10
Binimetinib + Brigatinib Binimetinib Brigatinib 0 1
Binimetinib + Buparlisib Binimetinib Buparlisib 3 0
Binimetinib + Buparlisib + Encorafenib Binimetinib Buparlisib Encorafenib 0 1
Binimetinib + Capmatinib + Encorafenib Binimetinib Capmatinib Encorafenib 0 1
Binimetinib + Carboplatin + Pemetrexed Binimetinib Carboplatin Pemetrexed 0 1
Binimetinib + Cetuximab Binimetinib Cetuximab 1 0
Binimetinib + Cetuximab + Encorafenib Binimetinib Cetuximab Encorafenib 3 2
Binimetinib + Cisplatin + Gemcitabine Binimetinib Cisplatin Gemcitabine 0 1
Binimetinib + Cytarabine + Idarubicin Binimetinib Cytarabine Idarubicin 0 1
Binimetinib + Docetaxel Binimetinib Docetaxel 0 1
Binimetinib + Encorafenib Binimetinib Encorafenib 13 11
Binimetinib + Encorafenib + Panitumumab Binimetinib Encorafenib Panitumumab 2 0
Binimetinib + Encorafenib + Ribociclib Binimetinib Encorafenib Ribociclib 0 2
Binimetinib + Erlotinib Binimetinib Erlotinib 0 1
Binimetinib + Everolimus Binimetinib Everolimus 4 0
Binimetinib + Fluorouracil + Irinotecan + Leucovorin Binimetinib Fluorouracil Irinotecan Leucovorin 0 1
Binimetinib + Fluorouracil + Irinotecan + Leucovorin + Pembrolizumab Binimetinib Fluorouracil Irinotecan Leucovorin Pembrolizumab 0 1
Binimetinib + Fluorouracil + Leucovorin + Oxaliplatin Binimetinib Fluorouracil Leucovorin Oxaliplatin 1 1
Binimetinib + Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Binimetinib Fluorouracil Leucovorin Oxaliplatin Pembrolizumab 0 1
Binimetinib + Gemcitabine + Oxaliplatin Binimetinib Gemcitabine Oxaliplatin 0 1
Binimetinib + GSK2636771 Binimetinib GSK2636771 2 0
Binimetinib + Imatinib Binimetinib Imatinib 0 1
Binimetinib + Ipilimumab + Nivolumab Binimetinib Ipilimumab Nivolumab 0 1
Binimetinib + Nilotinib Binimetinib Nilotinib 0 1
Binimetinib + Nivolumab Binimetinib Nivolumab 0 1
Binimetinib + Paclitaxel Binimetinib Paclitaxel 1 1
Binimetinib + Palbociclib Binimetinib Palbociclib 0 2
Binimetinib + Panitumumab Binimetinib Panitumumab 1 0
Binimetinib + Pembrolizumab Binimetinib Pembrolizumab 0 2
Binimetinib + Pexidartinib Binimetinib Pexidartinib 0 1
Binimetinib + Pictilisib Binimetinib Pictilisib 1 0
Binimetinib + Ribociclib Binimetinib Ribociclib 2 1


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