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CHZ868 is a type II JAK2 inhibitor, which stabilizes JAK2 in the inactive conformation resulting in decreased downstream signaling and potentially leading to decreased tumor cell growth (PMID: 26175413, PMID: 30498775).
|DrugClasses||JAK2 Inhibitor 16|
|CAS Registry Number||1895895-38-1|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|