Drug Detail

Drug Name Imatinib
Trade Name Gleevec
Synonyms CGP-57148B|STI571|Imatinib mesylate
Drug Descriptions

Gleevec (imatinib) is a multi-target inhibitor of c-Kit, Pdgfr, and Bcr-Abl (PMID: 12200353). Gleevec (imatinib) is FDA approved for c-KIT positive GIST and dermatofibrosarcoma protuberans, Philadelphia chromosome positive chronic myeloid leukemia, and FIP1L1-PDGFRA positive chronic eosinophilic leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 8 BCR-ABL Inhibitor 24 CSF1R Inhibitor 23 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Imatinib Afatinib Imatinib 0 0
AIC-47 + Imatinib AIC-47 Imatinib 0 0
AKI603 + Imatinib AKI603 Imatinib 0 0
Asciminib + Imatinib Asciminib Imatinib 0 1
BGB-324 + Imatinib BGB-324 Imatinib 0 0
BGJ398 + Imatinib BGJ398 Imatinib 3 1
Binimetinib + Imatinib Binimetinib Imatinib 0 1
Carboplatin + Imatinib + Paclitaxel Carboplatin Imatinib Paclitaxel 1 0
Cytarabine + Imatinib + Methotrexate Cytarabine Imatinib Methotrexate 0 1
Dexamethasone + Imatinib + Vincristine Dexamethasone Imatinib Vincristine 0 1
Everolimus + Imatinib Everolimus Imatinib 0 1
G007-LK + Imatinib G007-LK Imatinib 1 0
Gefitinib + Imatinib Gefitinib Imatinib 0 0
Imatinib Imatinib 126 19
Imatinib + Interferon alpha-2b Imatinib Interferon alpha-2b 0 1
Imatinib + Ipilimumab Imatinib Ipilimumab 0 1
Imatinib + Letrozole Imatinib Letrozole 1 0
Imatinib + LY294002 Imatinib LY294002 1 0
Imatinib + MK2206 Imatinib MK2206 4 0
Imatinib + Osimertinib Imatinib Osimertinib 0 0
Imatinib + Pembrolizumab Imatinib Pembrolizumab 0 2
Imatinib + PKF118-310 Imatinib PKF118-310 1 0
Imatinib + PLX4720 Imatinib PLX4720 1 0
Imatinib + Prednisone + Vincristine Imatinib Prednisone Vincristine 0 1
Imatinib + Ruxolitinib Imatinib Ruxolitinib 0 1
Imatinib + Serdemetan Imatinib Serdemetan 0 0
Imatinib + unspecified PD-1 antibody Imatinib unspecified PD-1 antibody 0 0
Imatinib + unspecified PD-L1 antibody Imatinib unspecified PD-L1 antibody 0 0
Imatinib + Venetoclax Imatinib Venetoclax 0 0
Imatinib + XAV939 Imatinib XAV939 1 0