Drug Detail


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Drug Name Asciminib
Trade Name Scemblix
Synonyms ABL001|ABL-001
Drug Descriptions

Scemblix (asciminib) is an allosteric inhibitor of BCR-ABL that binds to a unique location outside the ATP binding site, resulting in decreased BCR-ABL kinase activity and reduced tumor growth (PMID: 31543464, PMID: 31826340). Scemblix (asciminib) is FDA approved for use in patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP) after two or more tyrosine kinase inhibitor treatments, and in adult patients with Ph+ CML in CP harboring ABL1 T315I (FDA.gov).

DrugClasses BCR-ABL Inhibitor 31
CAS Registry Number 1492952-76-7
NCIT ID C114494


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Asciminib Asciminib 1 13
Asciminib + Blinatumomab Asciminib Blinatumomab 0 1
Asciminib + Blinatumomab + Dasatinib + Prednisone Asciminib Blinatumomab Dasatinib Prednisone 0 1
Asciminib + Dasatinib Asciminib Dasatinib 0 3
Asciminib + Dasatinib + Prednisone Asciminib Dasatinib Prednisone 0 0
Asciminib + Hydroxyurea + Ponatinib Asciminib Hydroxyurea Ponatinib 0 0
Asciminib + Imatinib Asciminib Imatinib 0 6
Asciminib + Nilotinib Asciminib Nilotinib 0 5
Asciminib + Ponatinib Asciminib Ponatinib 0 0

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